PROGNOSTIC VALUE OF NUCLEOLAR ORGANIZER REGIONS AND DNA PLOIDY IN GASTRIC-CANCER

  • Authors:
    • Y YONEMURA
    • M KAJI
    • H TAKAMURA
    • K SUGIYAMA
    • I NINOMIYA
    • K TSUGAWA
    • T FUJIMURA
    • H FUJITA
    • A YAMAGUCHI
    • G NISHIMURA
    • I MIYAZAKI
  • View Affiliations

  • Published online on: April 1, 1993     https://doi.org/10.3892/ijo.2.4.577
  • Pages: 577-582
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Abstract

The prognostic value of nucleolar organizer region (Ag-NOR) and ploidy status in 233 gastric cancer was determined. In addition, correlation of bromodeoxyuridine labeling indices (BrdU LIs) and Ag-NOR scores was studied. The proportion of Ag-NOR scores varied from 1.85 to 12.0 (mean, 3.6; S.D., 1.9). A significant correlation was found between Ag-NOR scores and BrdU LIs, tumor size, serosal invasion, and lymph node metastasis. By univariate analysis, Ag-NOR score was proved to be a significant prognostic indicator. However, Cox regression analysis revealed that Ag-NOR scores and DNA ploidy were not independent prognostic parameters. However, when the combination analysis of Ag-NOR scores and DNA ploidy was entered into the Cox model, this parameter emerged as an independent prognostic parameter. These studies indicate that Ag-NOR scores reflect proliferative activity of gastric cancer, and that the Ag-NOR scores may possibly be useful prognostic parameters, when combined with DNA ploidy.

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April 1993
Volume 2 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
YONEMURA Y, KAJI M, TAKAMURA H, SUGIYAMA K, NINOMIYA I, TSUGAWA K, FUJIMURA T, FUJITA H, YAMAGUCHI A, NISHIMURA G, NISHIMURA G, et al: PROGNOSTIC VALUE OF NUCLEOLAR ORGANIZER REGIONS AND DNA PLOIDY IN GASTRIC-CANCER. Int J Oncol 2: 577-582, 1993
APA
YONEMURA, Y., KAJI, M., TAKAMURA, H., SUGIYAMA, K., NINOMIYA, I., TSUGAWA, K. ... MIYAZAKI, I. (1993). PROGNOSTIC VALUE OF NUCLEOLAR ORGANIZER REGIONS AND DNA PLOIDY IN GASTRIC-CANCER. International Journal of Oncology, 2, 577-582. https://doi.org/10.3892/ijo.2.4.577
MLA
YONEMURA, Y., KAJI, M., TAKAMURA, H., SUGIYAMA, K., NINOMIYA, I., TSUGAWA, K., FUJIMURA, T., FUJITA, H., YAMAGUCHI, A., NISHIMURA, G., MIYAZAKI, I."PROGNOSTIC VALUE OF NUCLEOLAR ORGANIZER REGIONS AND DNA PLOIDY IN GASTRIC-CANCER". International Journal of Oncology 2.4 (1993): 577-582.
Chicago
YONEMURA, Y., KAJI, M., TAKAMURA, H., SUGIYAMA, K., NINOMIYA, I., TSUGAWA, K., FUJIMURA, T., FUJITA, H., YAMAGUCHI, A., NISHIMURA, G., MIYAZAKI, I."PROGNOSTIC VALUE OF NUCLEOLAR ORGANIZER REGIONS AND DNA PLOIDY IN GASTRIC-CANCER". International Journal of Oncology 2, no. 4 (1993): 577-582. https://doi.org/10.3892/ijo.2.4.577