HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS

  • Authors:
    • F ARVELO
    • MF POUPON
    • P BALDEYROU
    • T LECHEVALIER
  • View Affiliations

  • Published online on: April 1, 1993     https://doi.org/10.3892/ijo.2.4.621
  • Pages: 621-625
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Abstract

The analysis of oncogene expression may provide insights into the pathogenesis of small cell lung cancer (SCLC) and may help to predict clinical behavior. The expression of 8 oncogenes (c-myc, N-myc, L-myc, Ha-ras, Ki-ras, N-ras, erbB-2, v-sis) was evaluated in small cell lung cancer (SCLC) xenografts of tumor samples, recentlly transplanted, taken from 17 different patients. Eight of these 17 SCLC lines expressed the L-myc oncogene and 2 SCLC lines expressed the c-myc oncogene. One SCLC line (SCLC-63M) simultaneously expressed the L-myc and c-myc oncogenes. All SCLC lines examined had almost similar high RNA levels of the Ki-ras oncogene, while the expression of Ha- and N-ras oncogenes was not always observed. The N-myc and v-sis oncogenes were expressed in only one tumor and at a very weak level, and no transcript of the erbB-2 oncogene was observed in any of our 17 SCLC lines. These results indicate that oncogene expression in SCLC lines is heterogeneous, with the exception of the Ki-ras oncogene which is constantly overexpressed.

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April 1993
Volume 2 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
ARVELO F, POUPON M, BALDEYROU P and LECHEVALIER T: HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS. Int J Oncol 2: 621-625, 1993
APA
ARVELO, F., POUPON, M., BALDEYROU, P., & LECHEVALIER, T. (1993). HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS. International Journal of Oncology, 2, 621-625. https://doi.org/10.3892/ijo.2.4.621
MLA
ARVELO, F., POUPON, M., BALDEYROU, P., LECHEVALIER, T."HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS". International Journal of Oncology 2.4 (1993): 621-625.
Chicago
ARVELO, F., POUPON, M., BALDEYROU, P., LECHEVALIER, T."HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS". International Journal of Oncology 2, no. 4 (1993): 621-625. https://doi.org/10.3892/ijo.2.4.621