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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 1993 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 1993 Volume 2 Issue 4

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Article

HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS

  • Authors:
    • F ARVELO
    • MF POUPON
    • P BALDEYROU
    • T LECHEVALIER

  • View Affiliations / Copyright

    Affiliations: INST CURIE,CNRS,URA 620,26 RUE ULM,F-75231 PARIS 05,FRANCE. INST GUSTAVE ROUSSY,F-94805 VILLEJUIF,FRANCE.
  • Pages: 621-625
    |
    Published online on: April 1, 1993
       https://doi.org/10.3892/ijo.2.4.621
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Abstract

The analysis of oncogene expression may provide insights into the pathogenesis of small cell lung cancer (SCLC) and may help to predict clinical behavior. The expression of 8 oncogenes (c-myc, N-myc, L-myc, Ha-ras, Ki-ras, N-ras, erbB-2, v-sis) was evaluated in small cell lung cancer (SCLC) xenografts of tumor samples, recentlly transplanted, taken from 17 different patients. Eight of these 17 SCLC lines expressed the L-myc oncogene and 2 SCLC lines expressed the c-myc oncogene. One SCLC line (SCLC-63M) simultaneously expressed the L-myc and c-myc oncogenes. All SCLC lines examined had almost similar high RNA levels of the Ki-ras oncogene, while the expression of Ha- and N-ras oncogenes was not always observed. The N-myc and v-sis oncogenes were expressed in only one tumor and at a very weak level, and no transcript of the erbB-2 oncogene was observed in any of our 17 SCLC lines. These results indicate that oncogene expression in SCLC lines is heterogeneous, with the exception of the Ki-ras oncogene which is constantly overexpressed.

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Copy and paste a formatted citation
Spandidos Publications style
ARVELO F, POUPON M, BALDEYROU P and LECHEVALIER T: HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS. Int J Oncol 2: 621-625, 1993.
APA
ARVELO, F., POUPON, M., BALDEYROU, P., & LECHEVALIER, T. (1993). HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS. International Journal of Oncology, 2, 621-625. https://doi.org/10.3892/ijo.2.4.621
MLA
ARVELO, F., POUPON, M., BALDEYROU, P., LECHEVALIER, T."HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS". International Journal of Oncology 2.4 (1993): 621-625.
Chicago
ARVELO, F., POUPON, M., BALDEYROU, P., LECHEVALIER, T."HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS". International Journal of Oncology 2, no. 4 (1993): 621-625. https://doi.org/10.3892/ijo.2.4.621
Copy and paste a formatted citation
x
Spandidos Publications style
ARVELO F, POUPON M, BALDEYROU P and LECHEVALIER T: HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS. Int J Oncol 2: 621-625, 1993.
APA
ARVELO, F., POUPON, M., BALDEYROU, P., & LECHEVALIER, T. (1993). HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS. International Journal of Oncology, 2, 621-625. https://doi.org/10.3892/ijo.2.4.621
MLA
ARVELO, F., POUPON, M., BALDEYROU, P., LECHEVALIER, T."HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS". International Journal of Oncology 2.4 (1993): 621-625.
Chicago
ARVELO, F., POUPON, M., BALDEYROU, P., LECHEVALIER, T."HETEROGENEOUS EXPRESSION OF ONCOGENES IN SMALL-CELL LUNG-CANCER XENOGRAFTS". International Journal of Oncology 2, no. 4 (1993): 621-625. https://doi.org/10.3892/ijo.2.4.621
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