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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 1993 Volume 2 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 1993 Volume 2 Issue 4

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Article

EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS

  • Authors:
    • J VIGNOVICH
    • D BECKER

  • View Affiliations / Copyright

    Affiliations: UNIV PITTSBURGH,DEPT MED,BST E1050,DESOTO & O HARA ST,PITTSBURGH,PA 15261. UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15261.
  • Pages: 637-642
    |
    Published online on: April 1, 1993
       https://doi.org/10.3892/ijo.2.4.637
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Abstract

In an attempt to investigate the expression and possible function(s) of bFGF and the four members of the fibroblast growth factor receptor family, FGFR-1 -4, in a mesenchymal-derived cell system, we analyzed normal human myoblasts and rhabdomyosarcomas. RT-PCR analysis revealed expression of both the ligand bFGF and the FGF receptors, FGFR-1, FGFR-2, FGFR-3 and FGFR-4, in myoblasts and rhabdomyosarcomas; with FGFR-3 at comparably lower levels of detection. Antisense oligodeoxynucleotides targeted against the translation start site and splice-donor acceptor sites of human bFGF and FGFR-1 did not exert proliferation-inhibitory effects in either cell type. Thus, unlike previous studies which demonstrated the importance of bFGF and FGFR-1 as major contributors in sustaining,the proliferation of normal and malignant cells of neuroectodermal origin, the data presented here, indicate that cells of mesenchymal origin may rely on additional, if not altogether different, growth factors and growth factor receptors for their proliferation.

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Copy and paste a formatted citation
Spandidos Publications style
VIGNOVICH J and BECKER D: EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS. Int J Oncol 2: 637-642, 1993.
APA
VIGNOVICH, J., & BECKER, D. (1993). EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS. International Journal of Oncology, 2, 637-642. https://doi.org/10.3892/ijo.2.4.637
MLA
VIGNOVICH, J., BECKER, D."EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS". International Journal of Oncology 2.4 (1993): 637-642.
Chicago
VIGNOVICH, J., BECKER, D."EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS". International Journal of Oncology 2, no. 4 (1993): 637-642. https://doi.org/10.3892/ijo.2.4.637
Copy and paste a formatted citation
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Spandidos Publications style
VIGNOVICH J and BECKER D: EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS. Int J Oncol 2: 637-642, 1993.
APA
VIGNOVICH, J., & BECKER, D. (1993). EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS. International Journal of Oncology, 2, 637-642. https://doi.org/10.3892/ijo.2.4.637
MLA
VIGNOVICH, J., BECKER, D."EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS". International Journal of Oncology 2.4 (1993): 637-642.
Chicago
VIGNOVICH, J., BECKER, D."EXPRESSION OF BFGF AND DIFFERENTIAL EXPRESSION OF FGF RECEPTORS IN NORMAL HUMAN MYOBLASTS AND RHABDOMYOSARCOMAS". International Journal of Oncology 2, no. 4 (1993): 637-642. https://doi.org/10.3892/ijo.2.4.637
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