INVIVO CONTROL OF TUMOR-GROWTH WITH THE ASSOCIATION OF IONIDAMINE WITH RADIATION AND OR HYPERTHERMIA

  • Authors:
    • A CIVIDALLI
    • FP GENTILE
    • L BEGNOZZI
    • L CHIATTI
    • M BENASSI
    • A FLORIDI
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  • Published online on: May 1, 1993     https://doi.org/10.3892/ijo.2.5.791
  • Pages: 791-795
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Abstract

The effect of lonidamine (LND) in association with fractionated doses of radiation and/or hyperthermia on tumor growth has been evaluated. The results may be summarized as follows: (i) the fractionation of the radiation dose, in spite of the higher dose delivered (20 Gy) does not increase tumor growth delay when compared to that obtained with a single irradiation treatment. A similar behaviour was also found when the fractionated irradiation was associated with LND. (ii) Hyperthermia is less effective than radiation in controlling tumor growth, but its effect is potentiated by LND although to a lesser extent that with radiation. (iii) LND delivered together with hyperthermia and radiation arrests tumor growth, and leads to the disappearance of the tumor in 75% of mice. The possible mechanisms underlying these effects are discussed.

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May 1993
Volume 2 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
CIVIDALLI A, GENTILE F, BEGNOZZI L, CHIATTI L, BENASSI M and FLORIDI A: INVIVO CONTROL OF TUMOR-GROWTH WITH THE ASSOCIATION OF IONIDAMINE WITH RADIATION AND OR HYPERTHERMIA. Int J Oncol 2: 791-795, 1993
APA
CIVIDALLI, A., GENTILE, F., BEGNOZZI, L., CHIATTI, L., BENASSI, M., & FLORIDI, A. (1993). INVIVO CONTROL OF TUMOR-GROWTH WITH THE ASSOCIATION OF IONIDAMINE WITH RADIATION AND OR HYPERTHERMIA. International Journal of Oncology, 2, 791-795. https://doi.org/10.3892/ijo.2.5.791
MLA
CIVIDALLI, A., GENTILE, F., BEGNOZZI, L., CHIATTI, L., BENASSI, M., FLORIDI, A."INVIVO CONTROL OF TUMOR-GROWTH WITH THE ASSOCIATION OF IONIDAMINE WITH RADIATION AND OR HYPERTHERMIA". International Journal of Oncology 2.5 (1993): 791-795.
Chicago
CIVIDALLI, A., GENTILE, F., BEGNOZZI, L., CHIATTI, L., BENASSI, M., FLORIDI, A."INVIVO CONTROL OF TUMOR-GROWTH WITH THE ASSOCIATION OF IONIDAMINE WITH RADIATION AND OR HYPERTHERMIA". International Journal of Oncology 2, no. 5 (1993): 791-795. https://doi.org/10.3892/ijo.2.5.791