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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2002 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2002 Volume 20 Issue 1

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Article

Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells

  • Authors:
    • Giuliana Gobbi
    • Luca Sangiorgi
    • Luca Lenzi
    • Raffaella Casadei
    • Silvia Canaider
    • Pierluigi Strippoli
    • Enrico Lucarelli
    • Ilaria Ghedini
    • Davide Donati
    • Nicola Fabbri
    • Jorg Warzecha
    • Choh Yeoung
    • Lee J. Helman
    • Piero Picci
    • Paolo Carinci

  • View Affiliations / Copyright

    Affiliations: Laboratory of Oncology Research, Rizzoli Orthopaedic Institute, Bologna, Italy
  • Pages: 143-147
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/ijo.20.1.143
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Abstract

Members of the bone morphogenetic protein (BMP) family and their receptors (BMPRs and activin receptors-ActRs) promote the development of bones with a fine regulation of their expression. Mutations in BMPs or BMPRs cause several diseases, as shown in knockout mice, such as skeletal defects, familial primary pulmonary hypertension and neoplasias. Osteosarcoma is the most frequent primary malignant tumor of bone. Due to their importance in bone development, BMPs, BMPRs and ActRs could also play a role in osteosarcoma growth and development. Previous data have shown that the overexpression of the BMPR-II was related to poor prognosis in malignant and metastatic bone tumors. We evaluate by reverse transcription-linked polymerase chain reaction analysis (RT-PCR) the expression pattern of BMPs, BMPRs and ActRs in five different human osteosarcoma cell lines (MG63, G292, HOS, SaOS and U2). Moreover, we performed the mutational screening of the complete BMPR-II mRNA by automated sequencing of the correspondent cDNA to evaluate the presence of point mutations in osteosarcoma cell lines. All the osteosarcoma cell lines studied simultaneously expressed the BMPs, BMPRs and ActRs investigated. No mutations were detected in the BMPR-II cDNA. Our results suggest the presence of a mechanism involving the simultaneous activation of the BMPs and their receptors in osteosarcoma cell lines.

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Copy and paste a formatted citation
Spandidos Publications style
Gobbi G, Sangiorgi L, Lenzi L, Casadei R, Canaider S, Strippoli P, Lucarelli E, Ghedini I, Donati D, Fabbri N, Fabbri N, et al: Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells. Int J Oncol 20: 143-147, 2002.
APA
Gobbi, G., Sangiorgi, L., Lenzi, L., Casadei, R., Canaider, S., Strippoli, P. ... Carinci, P. (2002). Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells. International Journal of Oncology, 20, 143-147. https://doi.org/10.3892/ijo.20.1.143
MLA
Gobbi, G., Sangiorgi, L., Lenzi, L., Casadei, R., Canaider, S., Strippoli, P., Lucarelli, E., Ghedini, I., Donati, D., Fabbri, N., Warzecha, J., Yeoung, C., Helman, L. J., Picci, P., Carinci, P."Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells". International Journal of Oncology 20.1 (2002): 143-147.
Chicago
Gobbi, G., Sangiorgi, L., Lenzi, L., Casadei, R., Canaider, S., Strippoli, P., Lucarelli, E., Ghedini, I., Donati, D., Fabbri, N., Warzecha, J., Yeoung, C., Helman, L. J., Picci, P., Carinci, P."Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells". International Journal of Oncology 20, no. 1 (2002): 143-147. https://doi.org/10.3892/ijo.20.1.143
Copy and paste a formatted citation
x
Spandidos Publications style
Gobbi G, Sangiorgi L, Lenzi L, Casadei R, Canaider S, Strippoli P, Lucarelli E, Ghedini I, Donati D, Fabbri N, Fabbri N, et al: Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells. Int J Oncol 20: 143-147, 2002.
APA
Gobbi, G., Sangiorgi, L., Lenzi, L., Casadei, R., Canaider, S., Strippoli, P. ... Carinci, P. (2002). Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells. International Journal of Oncology, 20, 143-147. https://doi.org/10.3892/ijo.20.1.143
MLA
Gobbi, G., Sangiorgi, L., Lenzi, L., Casadei, R., Canaider, S., Strippoli, P., Lucarelli, E., Ghedini, I., Donati, D., Fabbri, N., Warzecha, J., Yeoung, C., Helman, L. J., Picci, P., Carinci, P."Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells". International Journal of Oncology 20.1 (2002): 143-147.
Chicago
Gobbi, G., Sangiorgi, L., Lenzi, L., Casadei, R., Canaider, S., Strippoli, P., Lucarelli, E., Ghedini, I., Donati, D., Fabbri, N., Warzecha, J., Yeoung, C., Helman, L. J., Picci, P., Carinci, P."Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells". International Journal of Oncology 20, no. 1 (2002): 143-147. https://doi.org/10.3892/ijo.20.1.143
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