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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2002 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2002 Volume 20 Issue 1

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Article

PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells

  • Authors:
    • R. Kaufmann
    • U. Junker
    • K. Nuske
    • M. Westermann
    • P. Henklein
    • J. Scheele
    • K. Junker

  • View Affiliations / Copyright

    Affiliations: Department of General and Visceral Surgery, Medical Faculty at the Friedrich Schiller University Jena, D-07740 Jena, Germany
  • Pages: 177-180
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/ijo.20.1.177
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Abstract

In this study, we report coexpression of proteinase-activated receptor (PAR)-1- and PAR-3-type thrombin receptors in primary cultures obtained from surgically resected specimens of renal cell carcinomas (RCCs). Receptor expression on RNA level was evaluated by using the RT-PCR technique. Results demonstrated the presence of mRNA encoding PAR-1 and PAR-3, but mRNA encoding PAR-4 could not be found in human RCC cells. The expression of PAR-1 and PAR-3 on protein level was investigated with confocal laser fluorescence and freeze-fracture electron microscopy. Both thrombin receptor types were localized on the cell membrane but were also found on intracellular compartments of RCC cells. On the outer cell membrane, clustering of PAR-1 and PAR-3 molecules was partly observed. This is the first study demonstrating presence of both PAR-1 and PAR-3 in human carcinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Kaufmann R, Junker U, Nuske K, Westermann M, Henklein P, Scheele J and Junker K: PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells. Int J Oncol 20: 177-180, 2002.
APA
Kaufmann, R., Junker, U., Nuske, K., Westermann, M., Henklein, P., Scheele, J., & Junker, K. (2002). PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells. International Journal of Oncology, 20, 177-180. https://doi.org/10.3892/ijo.20.1.177
MLA
Kaufmann, R., Junker, U., Nuske, K., Westermann, M., Henklein, P., Scheele, J., Junker, K."PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells". International Journal of Oncology 20.1 (2002): 177-180.
Chicago
Kaufmann, R., Junker, U., Nuske, K., Westermann, M., Henklein, P., Scheele, J., Junker, K."PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells". International Journal of Oncology 20, no. 1 (2002): 177-180. https://doi.org/10.3892/ijo.20.1.177
Copy and paste a formatted citation
x
Spandidos Publications style
Kaufmann R, Junker U, Nuske K, Westermann M, Henklein P, Scheele J and Junker K: PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells. Int J Oncol 20: 177-180, 2002.
APA
Kaufmann, R., Junker, U., Nuske, K., Westermann, M., Henklein, P., Scheele, J., & Junker, K. (2002). PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells. International Journal of Oncology, 20, 177-180. https://doi.org/10.3892/ijo.20.1.177
MLA
Kaufmann, R., Junker, U., Nuske, K., Westermann, M., Henklein, P., Scheele, J., Junker, K."PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells". International Journal of Oncology 20.1 (2002): 177-180.
Chicago
Kaufmann, R., Junker, U., Nuske, K., Westermann, M., Henklein, P., Scheele, J., Junker, K."PAR-1- and PAR-3-type thrombin receptor expression in primary cultures of human renal cell carcinoma cells". International Journal of Oncology 20, no. 1 (2002): 177-180. https://doi.org/10.3892/ijo.20.1.177
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