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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2002 Volume 20 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2002 Volume 20 Issue 1

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Article

Expression of metastasis-related genes in human epithelial ovarian tumors

  • Authors:
    • C. A. Herrera
    • L. Xu
    • C. D. Bucana
    • E. G. Silva
    • K. R. Hess
    • D. M. Gershenson
    • I. J. Fidler

  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 5-13
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/ijo.20.1.5
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Abstract

We examined the expression level of several genes that regulate distinct steps of metastasis in 55 formalin-fixed, paraffin-embedded, archival specimens of primary human ovarian carcinoma from patients undergoing curative surgery. The expression of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), basic fibroblast growth factor (bFGF), E-cadherin, type IV collagenase, matrix metalloproteinase (MMP-2 and MMP-9), and interleukin 8 (IL-8) was examined by a colorimetric in situ mRNA hybridization technique. The expression level of E-cadherin, MMP-2, MMP-9, VEGF, and IL-8 mRNA correlated with disease stages. The ratio of type IV collagenase expression (mean of the expression of MMP-2 and MMP-9) to E-cadherin expression (MMP:E-cadherin ratio) increased with increasing stage of disease (p<0.0001). Death rates significantly increased with high MMP:E-cadherin ratio (p=0.0005). Multivariate analysis of overall survival showed that the MMP:E-cadherin ratio was a significant independent prognostic factor, even after adjustment for known prognostic factors, such as histology, stage, and age.

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Copy and paste a formatted citation
Spandidos Publications style
Herrera CA, Xu L, Bucana CD, Silva EG, Hess KR, Gershenson DM and Fidler IJ: Expression of metastasis-related genes in human epithelial ovarian tumors. Int J Oncol 20: 5-13, 2002.
APA
Herrera, C.A., Xu, L., Bucana, C.D., Silva, E.G., Hess, K.R., Gershenson, D.M., & Fidler, I.J. (2002). Expression of metastasis-related genes in human epithelial ovarian tumors. International Journal of Oncology, 20, 5-13. https://doi.org/10.3892/ijo.20.1.5
MLA
Herrera, C. A., Xu, L., Bucana, C. D., Silva, E. G., Hess, K. R., Gershenson, D. M., Fidler, I. J."Expression of metastasis-related genes in human epithelial ovarian tumors". International Journal of Oncology 20.1 (2002): 5-13.
Chicago
Herrera, C. A., Xu, L., Bucana, C. D., Silva, E. G., Hess, K. R., Gershenson, D. M., Fidler, I. J."Expression of metastasis-related genes in human epithelial ovarian tumors". International Journal of Oncology 20, no. 1 (2002): 5-13. https://doi.org/10.3892/ijo.20.1.5
Copy and paste a formatted citation
x
Spandidos Publications style
Herrera CA, Xu L, Bucana CD, Silva EG, Hess KR, Gershenson DM and Fidler IJ: Expression of metastasis-related genes in human epithelial ovarian tumors. Int J Oncol 20: 5-13, 2002.
APA
Herrera, C.A., Xu, L., Bucana, C.D., Silva, E.G., Hess, K.R., Gershenson, D.M., & Fidler, I.J. (2002). Expression of metastasis-related genes in human epithelial ovarian tumors. International Journal of Oncology, 20, 5-13. https://doi.org/10.3892/ijo.20.1.5
MLA
Herrera, C. A., Xu, L., Bucana, C. D., Silva, E. G., Hess, K. R., Gershenson, D. M., Fidler, I. J."Expression of metastasis-related genes in human epithelial ovarian tumors". International Journal of Oncology 20.1 (2002): 5-13.
Chicago
Herrera, C. A., Xu, L., Bucana, C. D., Silva, E. G., Hess, K. R., Gershenson, D. M., Fidler, I. J."Expression of metastasis-related genes in human epithelial ovarian tumors". International Journal of Oncology 20, no. 1 (2002): 5-13. https://doi.org/10.3892/ijo.20.1.5
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