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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2002 Volume 20 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors

  • Authors:
    • Barbara Seliger
    • Michaela Bock
    • Ulrike Ritz
    • Christoph Huber

  • View Affiliations / Copyright

    Affiliations: Johannes Gutenberg University, Third Department of Internal Medicine, D-55101 Mainz, Germany
  • Pages: 349-353
    |
    Published online on: February 1, 2002
       https://doi.org/10.3892/ijo.20.2.349
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Abstract

The Tap1 and Tap2 genes encoding for a heterodimeric peptide transporter play a key role in antigen processing and presentation. The TAP complex mediates the transport of peptides generated by the IFN-γ-inducible proteasome subunits LMP2, 7 and 10 from the cytosol into the endoplasmic reticulum (ER), where they bind to MHC class I molecules. In contrast to the frequent polymorphisms within the rat Tap genes which exert functional differences, polymorphic regions within the human Tap genes have been demonstrated, but not systematically analyzed in terms of their functional significance. Both the Tap1 and Lmp2 genes are transcribed from a bidirectional intergenic promoter which is regulated by at least three sequences located in the Tap1 proximal region. We describe here a polymorphic site in the shared TAP1/LMP2 promoter which frequently occurred in human tumor cells of distinct origin. This polymorphism resulted in a G↷T substitution 151 bp upstream of the translation start of Tap1. Using transient transfection assays with luciferase reporter constructs, the transcriptional activities of the different allelic variants of the TAP1/LMP2 promoter were comparable suggesting no functional consequences of this TAP1/LMP2 promoter polymorphism.

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Copy and paste a formatted citation
Spandidos Publications style
Seliger B, Bock M, Ritz U and Huber C: High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors. Int J Oncol 20: 349-353, 2002.
APA
Seliger, B., Bock, M., Ritz, U., & Huber, C. (2002). High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors. International Journal of Oncology, 20, 349-353. https://doi.org/10.3892/ijo.20.2.349
MLA
Seliger, B., Bock, M., Ritz, U., Huber, C."High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors". International Journal of Oncology 20.2 (2002): 349-353.
Chicago
Seliger, B., Bock, M., Ritz, U., Huber, C."High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors". International Journal of Oncology 20, no. 2 (2002): 349-353. https://doi.org/10.3892/ijo.20.2.349
Copy and paste a formatted citation
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Spandidos Publications style
Seliger B, Bock M, Ritz U and Huber C: High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors. Int J Oncol 20: 349-353, 2002.
APA
Seliger, B., Bock, M., Ritz, U., & Huber, C. (2002). High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors. International Journal of Oncology, 20, 349-353. https://doi.org/10.3892/ijo.20.2.349
MLA
Seliger, B., Bock, M., Ritz, U., Huber, C."High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors". International Journal of Oncology 20.2 (2002): 349-353.
Chicago
Seliger, B., Bock, M., Ritz, U., Huber, C."High frequency of a non-functional TAP1/LMP2 promoter polymorphism in human tumors". International Journal of Oncology 20, no. 2 (2002): 349-353. https://doi.org/10.3892/ijo.20.2.349
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