Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma

  • Authors:
    • Noriyasu Uwatoko
    • Tetsuji Tokunaga
    • Hiroyuki Hatanaka
    • Hideo Osada
    • Tsutomu Kawakami
    • Hitoshi Yamazaki
    • Yoshiyuki Abe
    • Hiroshi Kijima
    • Yoshito Ueyama
    • Masato Nakamura
  • View Affiliations

  • Published online on: April 1, 2002     https://doi.org/10.3892/ijo.20.4.729
  • Pages: 729-733
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Abstract

Interleukin-10 (IL-10) is an immunomodulative cytokine produced by T cells, B cells, and monocytic cells. The significance of IL-10 and IL-10R expression in renal cell carcinoma (RCC) has not been well characterized. In this study, we assessed the correlation between IL-10 gene expression and its pathological significance in 44 RCC specimens. The patients with IL-10 gene expression showed a decreased incidence of metastasis compared to those without IL-10 gene expression. The expression of IL-10 was correlated with vascular endothelial growth factor (VEGF)-A gene expression. These findings suggest that IL-10 gene expression plays some roles in the metastasis of RCC.

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April 2002
Volume 20 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Uwatoko N, Tokunaga T, Hatanaka H, Osada H, Kawakami T, Yamazaki H, Abe Y, Kijima H, Ueyama Y, Nakamura M, Nakamura M, et al: Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma. Int J Oncol 20: 729-733, 2002
APA
Uwatoko, N., Tokunaga, T., Hatanaka, H., Osada, H., Kawakami, T., Yamazaki, H. ... Nakamura, M. (2002). Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma. International Journal of Oncology, 20, 729-733. https://doi.org/10.3892/ijo.20.4.729
MLA
Uwatoko, N., Tokunaga, T., Hatanaka, H., Osada, H., Kawakami, T., Yamazaki, H., Abe, Y., Kijima, H., Ueyama, Y., Nakamura, M."Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma". International Journal of Oncology 20.4 (2002): 729-733.
Chicago
Uwatoko, N., Tokunaga, T., Hatanaka, H., Osada, H., Kawakami, T., Yamazaki, H., Abe, Y., Kijima, H., Ueyama, Y., Nakamura, M."Expression of interleukin-10 is inversely correlated with distant metastasis of renal cell carcinoma". International Journal of Oncology 20, no. 4 (2002): 729-733. https://doi.org/10.3892/ijo.20.4.729