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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2002 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2002 Volume 20 Issue 5

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Article

NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation

  • Authors:
    • Hong Zhang
    • Wenting Fu
  • View Affiliations / Copyright

    Affiliations: University Women's Hospital Basel, CH-4031 Basel, Switzerland. hzhang@uhbs.ch
  • Pages: 1035-1040
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijo.20.5.1035
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Abstract

We have identified several novel human caspase recruitment domain (CARD) containing genes. In this report, we describe one among them, NDPP1. The mRNA expression of NDPP1 was higher in the kidney and testis of normal tissues. High expression was also detected in breast cancer, prostate cancer and granulosa tumor cells but not in bladder cancer cells. Transfection experiments demonstrated that NDPP1 was able to supress Bax-induced apoptosis in REF52 cells. Furthermore, NDPP1 is able to inhibit NF-κB activation induced by TNF-α treatment in HepG2 cells. Our results demonstrated that NDPP1 is a novel member of the CARD family and a negative regulator of cell death and inflammatory response. The NDPP1 locus has been assigned to chromosome 19q13.3. The NDPP1 gene consists of 14 exons and transcribts for at least five splicing variants.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H and Fu W: NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation. Int J Oncol 20: 1035-1040, 2002.
APA
Zhang, H., & Fu, W. (2002). NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation. International Journal of Oncology, 20, 1035-1040. https://doi.org/10.3892/ijo.20.5.1035
MLA
Zhang, H., Fu, W."NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation". International Journal of Oncology 20.5 (2002): 1035-1040.
Chicago
Zhang, H., Fu, W."NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation". International Journal of Oncology 20, no. 5 (2002): 1035-1040. https://doi.org/10.3892/ijo.20.5.1035
Copy and paste a formatted citation
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Spandidos Publications style
Zhang H and Fu W: NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation. Int J Oncol 20: 1035-1040, 2002.
APA
Zhang, H., & Fu, W. (2002). NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation. International Journal of Oncology, 20, 1035-1040. https://doi.org/10.3892/ijo.20.5.1035
MLA
Zhang, H., Fu, W."NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation". International Journal of Oncology 20.5 (2002): 1035-1040.
Chicago
Zhang, H., Fu, W."NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-κB activation". International Journal of Oncology 20, no. 5 (2002): 1035-1040. https://doi.org/10.3892/ijo.20.5.1035
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