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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2002 Volume 20 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2002 Volume 20 Issue 5

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Article

Effect of hypoxia on human seminoma cells

  • Authors:
    • Tomohiro Fujii
    • Takemi Otsuki
    • Takuya Moriya
    • Haruko Sakaguchi
    • Junichi Kurebayashi
    • Kenichiro Yata
    • Masako Uno
    • Tatsuya Kobayashi
    • Takahiro Kimura
    • Yoshimasa Jo
    • Keigo Kinugawa
    • Yoji Furukawa
    • Masaaki Morioka
    • Ayako Ueki
    • Hiroyoshi Tanaka

  • View Affiliations / Copyright

    Affiliations: Department of Urology, Kawasaki Medical School, Okayama 701-0192, Japan
  • Pages: 955-962
    |
    Published online on: May 1, 2002
       https://doi.org/10.3892/ijo.20.5.955
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Abstract

Since hypoxia has been considered to enhance metastatic potential in solid tumors via a neo-angiogenesis caused by vascular endothelial cell growth factors (VEGFs) induced by hypoxia inducible factor-1α (HIF-1α), the effects of hypoxia on human seminoma cell lines were examined in terms of growth, morphology, gene expression, protein expression and cell cycle perturbation. Growth was inhibited in long-term cultures with morphological changes to the spindle form. The gene expression of VEGF-C was markedly enhanced and the production of VEGF-A increased during hypoxia, although HIF-1α was not upregulated at the protein or message level. Hypoxic culture caused G1 cell cycle arrest with upregulation of the p15/ink4b and p27/Kip1 genes, whereas no increase of apoptotic cells was observed on up-regulation of the heat shock protein (HSP) 70 gene. The adhesion molecules were only slightly altered.

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Copy and paste a formatted citation
Spandidos Publications style
Fujii T, Otsuki T, Moriya T, Sakaguchi H, Kurebayashi J, Yata K, Uno M, Kobayashi T, Kimura T, Jo Y, Jo Y, et al: Effect of hypoxia on human seminoma cells. Int J Oncol 20: 955-962, 2002.
APA
Fujii, T., Otsuki, T., Moriya, T., Sakaguchi, H., Kurebayashi, J., Yata, K. ... Tanaka, H. (2002). Effect of hypoxia on human seminoma cells. International Journal of Oncology, 20, 955-962. https://doi.org/10.3892/ijo.20.5.955
MLA
Fujii, T., Otsuki, T., Moriya, T., Sakaguchi, H., Kurebayashi, J., Yata, K., Uno, M., Kobayashi, T., Kimura, T., Jo, Y., Kinugawa, K., Furukawa, Y., Morioka, M., Ueki, A., Tanaka, H."Effect of hypoxia on human seminoma cells". International Journal of Oncology 20.5 (2002): 955-962.
Chicago
Fujii, T., Otsuki, T., Moriya, T., Sakaguchi, H., Kurebayashi, J., Yata, K., Uno, M., Kobayashi, T., Kimura, T., Jo, Y., Kinugawa, K., Furukawa, Y., Morioka, M., Ueki, A., Tanaka, H."Effect of hypoxia on human seminoma cells". International Journal of Oncology 20, no. 5 (2002): 955-962. https://doi.org/10.3892/ijo.20.5.955
Copy and paste a formatted citation
x
Spandidos Publications style
Fujii T, Otsuki T, Moriya T, Sakaguchi H, Kurebayashi J, Yata K, Uno M, Kobayashi T, Kimura T, Jo Y, Jo Y, et al: Effect of hypoxia on human seminoma cells. Int J Oncol 20: 955-962, 2002.
APA
Fujii, T., Otsuki, T., Moriya, T., Sakaguchi, H., Kurebayashi, J., Yata, K. ... Tanaka, H. (2002). Effect of hypoxia on human seminoma cells. International Journal of Oncology, 20, 955-962. https://doi.org/10.3892/ijo.20.5.955
MLA
Fujii, T., Otsuki, T., Moriya, T., Sakaguchi, H., Kurebayashi, J., Yata, K., Uno, M., Kobayashi, T., Kimura, T., Jo, Y., Kinugawa, K., Furukawa, Y., Morioka, M., Ueki, A., Tanaka, H."Effect of hypoxia on human seminoma cells". International Journal of Oncology 20.5 (2002): 955-962.
Chicago
Fujii, T., Otsuki, T., Moriya, T., Sakaguchi, H., Kurebayashi, J., Yata, K., Uno, M., Kobayashi, T., Kimura, T., Jo, Y., Kinugawa, K., Furukawa, Y., Morioka, M., Ueki, A., Tanaka, H."Effect of hypoxia on human seminoma cells". International Journal of Oncology 20, no. 5 (2002): 955-962. https://doi.org/10.3892/ijo.20.5.955
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