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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2002 Volume 20 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2002 Volume 20 Issue 6

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Article

The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus

  • Authors:
    • Markus Menges
    • Burkhard Michaeli
    • Werner Pueschel
    • Martin Zeitz
    • Eckart Meese

  • View Affiliations / Copyright

    Affiliations: Gastroenterology Section, Department of Medicine II, University of the Saarland, Homburg, Germany
  • Pages: 1323-1329
    |
    Published online on: June 1, 2002
       https://doi.org/10.3892/ijo.20.6.1323
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Abstract

About 10% of Barrett's patients develop an adenocarcinoma in the course of life. There is increasing evidence that persistent gastrooesophageal reflux is involved in carcinogenesis. We investigated whether the gene expression pattern of Barrett's epithelium cells changes upon suppression of gastrooesophageal reflux compared to unsuppressed reflux. Biopsies from various regions of Barrett's segments and, further, during and without proton pump inhibitor therapy were collected in 5 patients. The reflux profile was assessed by simultaneous 24-h oesophageal pH and bile reflux testing. m-RNA was extracted from the specimens, and integrity and absence of DNA proven by gel electrophoresis and ALU-PCR. Using the micro array technique 1,176 genes were analysed and assigned an expression level. The number of genes detected in each experiment varied from 86 to 136. There was a 91% concordance of the gene expression pattern in distal and proximal biopsies from an individual Barrett's segment. Concordance was much less (68%) between biopsies of the same patient taken during and without proton pump inhibitor therapy. The gene expression pattern in a Barrett's oesophagus varies dependent upon different reflux situations. Other factors like the location of biopsy are of minor importance. The micro array technique allows for selection of candidate genes important in carcinogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Menges M, Michaeli B, Pueschel W, Zeitz M and Meese E: The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus. Int J Oncol 20: 1323-1329, 2002.
APA
Menges, M., Michaeli, B., Pueschel, W., Zeitz, M., & Meese, E. (2002). The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus. International Journal of Oncology, 20, 1323-1329. https://doi.org/10.3892/ijo.20.6.1323
MLA
Menges, M., Michaeli, B., Pueschel, W., Zeitz, M., Meese, E."The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus". International Journal of Oncology 20.6 (2002): 1323-1329.
Chicago
Menges, M., Michaeli, B., Pueschel, W., Zeitz, M., Meese, E."The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus". International Journal of Oncology 20, no. 6 (2002): 1323-1329. https://doi.org/10.3892/ijo.20.6.1323
Copy and paste a formatted citation
x
Spandidos Publications style
Menges M, Michaeli B, Pueschel W, Zeitz M and Meese E: The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus. Int J Oncol 20: 1323-1329, 2002.
APA
Menges, M., Michaeli, B., Pueschel, W., Zeitz, M., & Meese, E. (2002). The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus. International Journal of Oncology, 20, 1323-1329. https://doi.org/10.3892/ijo.20.6.1323
MLA
Menges, M., Michaeli, B., Pueschel, W., Zeitz, M., Meese, E."The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus". International Journal of Oncology 20.6 (2002): 1323-1329.
Chicago
Menges, M., Michaeli, B., Pueschel, W., Zeitz, M., Meese, E."The influence of the suppression of gastrooesophageal reflux on the gene expression pattern in Barrett's oesophagus". International Journal of Oncology 20, no. 6 (2002): 1323-1329. https://doi.org/10.3892/ijo.20.6.1323
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