Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells

  • Authors:
    • Elena Pichichero
    • Rosella Cicconi
    • Maurizio Mattei
    • Antonella Canini
  • View Affiliations

  • Published online on: December 17, 2010     https://doi.org/10.3892/ijo.2010.876
  • Pages:473-483
0

Abstract

Chrysin (5,7-dihydroxyflavone) is a natural and biologically active compound extracted from honey, plants and propolis. It possesses anti-inflammatory activity, anti-oxidant properties and promotes cell death by perturbing cell cycle progression. In this study, our attention focused on the possible role that chrysin may have as a potential anti-cancer agent, and we tested its biological activity in murine and human melanoma cell lines (B16-F1 and A375). This study demonstrated that chrysin reduced melanoma cell proliferation and induced cell differentiation in both human and murine melanoma cells through synthesis increase and intracellular accumulation of protoporphirin IX (PpIX). Furthermore, following treatments with chrysin an increase in the expression of porphobilinogen deaminase (PBG-D) was noted. This study demontrated also that chrysin induces cell death in human and murine melanoma cells through caspase-dependent mechanisms, involving down-regulation of ERK 1/2, and activation of p38 MAP kinases. Induction of cell death may be a promising therapeutic approach in cancer therapy. Our results suggest that chrysin may be considered a potential candidate for both cancer prevention and treatment.

Related Articles

Journal Cover

February 2011
Volume 38 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

2016 Impact Factor: 3.079
Ranked #33/217 Oncology
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Pichichero, E., Cicconi, R., Mattei, M., & Canini, A. (2011). Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. International Journal of Oncology, 38, 473-483. https://doi.org/10.3892/ijo.2010.876
MLA
Pichichero, E., Cicconi, R., Mattei, M., Canini, A."Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells". International Journal of Oncology 38.2 (2011): 473-483.
Chicago
Pichichero, E., Cicconi, R., Mattei, M., Canini, A."Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells". International Journal of Oncology 38, no. 2 (2011): 473-483. https://doi.org/10.3892/ijo.2010.876