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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2011 Volume 38 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2011 Volume 38 Issue 2

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Article

Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells

  • Authors:
    • Elena Pichichero
    • Rosella Cicconi
    • Maurizio Mattei
    • Antonella Canini

  • View Affiliations / Copyright

    Affiliations: Department of Biology, Honey Research Center, University of Rome ‘Tor Vergata’, Via della Ricerca Scientifica 1, Rome, Italy, Honey Research Center, Department of Biology University of Rome Tor Vergata, Via della Ricerca Scientifica, 1-00133 Rome, Italy
  • Pages: 473-483
    |
    Published online on: December 17, 2010
       https://doi.org/10.3892/ijo.2010.876
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Abstract

Chrysin (5,7-dihydroxyflavone) is a natural and biologically active compound extracted from honey, plants and propolis. It possesses anti-inflammatory activity, anti-oxidant properties and promotes cell death by perturbing cell cycle progression. In this study, our attention focused on the possible role that chrysin may have as a potential anti-cancer agent, and we tested its biological activity in murine and human melanoma cell lines (B16-F1 and A375). This study demonstrated that chrysin reduced melanoma cell proliferation and induced cell differentiation in both human and murine melanoma cells through synthesis increase and intracellular accumulation of protoporphirin IX (PpIX). Furthermore, following treatments with chrysin an increase in the expression of porphobilinogen deaminase (PBG-D) was noted. This study demontrated also that chrysin induces cell death in human and murine melanoma cells through caspase-dependent mechanisms, involving down-regulation of ERK 1/2, and activation of p38 MAP kinases. Induction of cell death may be a promising therapeutic approach in cancer therapy. Our results suggest that chrysin may be considered a potential candidate for both cancer prevention and treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Pichichero E, Cicconi R, Mattei M and Canini A: Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. Int J Oncol 38: 473-483, 2011.
APA
Pichichero, E., Cicconi, R., Mattei, M., & Canini, A. (2011). Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. International Journal of Oncology, 38, 473-483. https://doi.org/10.3892/ijo.2010.876
MLA
Pichichero, E., Cicconi, R., Mattei, M., Canini, A."Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells". International Journal of Oncology 38.2 (2011): 473-483.
Chicago
Pichichero, E., Cicconi, R., Mattei, M., Canini, A."Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells". International Journal of Oncology 38, no. 2 (2011): 473-483. https://doi.org/10.3892/ijo.2010.876
Copy and paste a formatted citation
x
Spandidos Publications style
Pichichero E, Cicconi R, Mattei M and Canini A: Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. Int J Oncol 38: 473-483, 2011.
APA
Pichichero, E., Cicconi, R., Mattei, M., & Canini, A. (2011). Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. International Journal of Oncology, 38, 473-483. https://doi.org/10.3892/ijo.2010.876
MLA
Pichichero, E., Cicconi, R., Mattei, M., Canini, A."Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells". International Journal of Oncology 38.2 (2011): 473-483.
Chicago
Pichichero, E., Cicconi, R., Mattei, M., Canini, A."Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells". International Journal of Oncology 38, no. 2 (2011): 473-483. https://doi.org/10.3892/ijo.2010.876
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