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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 2011 Volume 39 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2011 Volume 39 Issue 2

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Article Open Access

miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer

  • Authors:
    • Pinar Akçakaya
    • Susanne Ekelund
    • Iryna Kolosenko
    • Stefano Caramuta
    • Deniz M. Özata
    • Hong Xie
    • Ulrik Lindforss
    • Hans Olivecrona
    • Weng-Onn Lui

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Medicine and Surgery, CMM L8:01, Karolinska University Hospital-Solna, SE-17176 Stockholm, Sweden
  • Pages: 311-318
    |
    Published online on: May 13, 2011
       https://doi.org/10.3892/ijo.2011.1043
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Abstract

Colorectal cancer (CRC) is one of the most common and deadly forms of cancer. Despite improved treatment modalities, post-operative recurrence and metastasis remain the major problems for extending patient survival after surgery. This highlights the need to search for biomarkers for prognostication and treatment stratification of colorectal cancer patients. In this study, we applied the SYBR-green quantitative PCR-based array approach to screen for differentially expressed miRNAs between patients with short (<50 months, range 10-33 months) and long survival (≥50 months, range 50-152 months). The selected candidate prognostic miRNAs were validated in a cohort of 50 CRC patients by TaqMan quantitative PCR. We found that high expression of miR-185 and low expression of miR-133b were correlated with poor survival (p=0.001 and 0.028, respectively) and metastasis (p=0.007 and 0.036, respectively) in colorectal cancer. Our findings suggest the potential prognostic values of these miRNAs for predicting clinical outcome after surgery.

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Copy and paste a formatted citation
Spandidos Publications style
Akçakaya P, Ekelund S, Kolosenko I, Caramuta S, Özata DM, Xie H, Lindforss U, Olivecrona H and Lui W: miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer. Int J Oncol 39: 311-318, 2011.
APA
Akçakaya, P., Ekelund, S., Kolosenko, I., Caramuta, S., Özata, D.M., Xie, H. ... Lui, W. (2011). miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer. International Journal of Oncology, 39, 311-318. https://doi.org/10.3892/ijo.2011.1043
MLA
Akçakaya, P., Ekelund, S., Kolosenko, I., Caramuta, S., Özata, D. M., Xie, H., Lindforss, U., Olivecrona, H., Lui, W."miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer". International Journal of Oncology 39.2 (2011): 311-318.
Chicago
Akçakaya, P., Ekelund, S., Kolosenko, I., Caramuta, S., Özata, D. M., Xie, H., Lindforss, U., Olivecrona, H., Lui, W."miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer". International Journal of Oncology 39, no. 2 (2011): 311-318. https://doi.org/10.3892/ijo.2011.1043
Copy and paste a formatted citation
x
Spandidos Publications style
Akçakaya P, Ekelund S, Kolosenko I, Caramuta S, Özata DM, Xie H, Lindforss U, Olivecrona H and Lui W: miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer. Int J Oncol 39: 311-318, 2011.
APA
Akçakaya, P., Ekelund, S., Kolosenko, I., Caramuta, S., Özata, D.M., Xie, H. ... Lui, W. (2011). miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer. International Journal of Oncology, 39, 311-318. https://doi.org/10.3892/ijo.2011.1043
MLA
Akçakaya, P., Ekelund, S., Kolosenko, I., Caramuta, S., Özata, D. M., Xie, H., Lindforss, U., Olivecrona, H., Lui, W."miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer". International Journal of Oncology 39.2 (2011): 311-318.
Chicago
Akçakaya, P., Ekelund, S., Kolosenko, I., Caramuta, S., Özata, D. M., Xie, H., Lindforss, U., Olivecrona, H., Lui, W."miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer". International Journal of Oncology 39, no. 2 (2011): 311-318. https://doi.org/10.3892/ijo.2011.1043
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