Dickkopf-1 in human oral cancer

  • Authors:
    • Kenji Ogoshi
    • Atsushi Kasamatsu
    • Manabu Iyoda
    • Kentaro Sakuma
    • Masanobu Yamatoji
    • Yosuke Sakamoto
    • Katsunori Ogawara
    • Masashi Shiiba
    • Hideki Tanzawa
    • Katsuhiro Uzawa
  • View Affiliations

  • Published online on: May 20, 2011     https://doi.org/10.3892/ijo.2011.1046
  • Pages: 329-336
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Abstract

Dickkopf-1 (Dkk1), a negative regulator of the Wnt signaling pathway, is implicated in tumorigenesis in several types of cancer. The purpose of this study was to determine the involvement of Dkk1 in oral squamous cell carcinoma (OSCC). We found that Dkk1 is frequently upregulated in OSCC-derived cell lines and primary OSCCs compared with normal counterparts. Unexpectedly, Dkk1-positive cases were correlated significantly (P<0.05) with a low risk of regional lymph node metastasis. We also found that cellular migration and invasiveness increased in Dkk1 knockdown cells and decreased in Dkk1 overexpressed cells. Furthermore, we investigated the relationship between the expression of Dkk1 and distribution of β-catenin in OSCC cells, since the Wnt signaling pathway is related closely to β-catenin. Whereas alteration of the β-catenin levels was not observed in each subcellular fractionation, the phosphorylated β-catenin levels in nuclei increased in Dkk1 knockdown cells and decreased in Dkk1 overexpressed cells. These data indicated that the high phosphorylation level of β-catenin in nuclei was correlated with a high risk of tumor invasiveness. The current study suggested that Dkk1 plays an important role in regulating cellular migration and invasiveness, making Dkk1 a potential biomarker for early detection of lymph node metastasis in OSCCs.

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August 2011
Volume 39 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ogoshi K, Kasamatsu A, Iyoda M, Sakuma K, Yamatoji M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K, Uzawa K, et al: Dickkopf-1 in human oral cancer. Int J Oncol 39: 329-336, 2011.
APA
Ogoshi, K., Kasamatsu, A., Iyoda, M., Sakuma, K., Yamatoji, M., Sakamoto, Y. ... Uzawa, K. (2011). Dickkopf-1 in human oral cancer. International Journal of Oncology, 39, 329-336. https://doi.org/10.3892/ijo.2011.1046
MLA
Ogoshi, K., Kasamatsu, A., Iyoda, M., Sakuma, K., Yamatoji, M., Sakamoto, Y., Ogawara, K., Shiiba, M., Tanzawa, H., Uzawa, K."Dickkopf-1 in human oral cancer". International Journal of Oncology 39.2 (2011): 329-336.
Chicago
Ogoshi, K., Kasamatsu, A., Iyoda, M., Sakuma, K., Yamatoji, M., Sakamoto, Y., Ogawara, K., Shiiba, M., Tanzawa, H., Uzawa, K."Dickkopf-1 in human oral cancer". International Journal of Oncology 39, no. 2 (2011): 329-336. https://doi.org/10.3892/ijo.2011.1046