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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2011 Volume 39 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2011 Volume 39 Issue 4

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Article

β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma

  • Authors:
    • Lingchao Chen
    • Kai Huang
    • Lei Han
    • Zhendong Shi
    • Kailiang Zhang
    • Peiyu Pu
    • Chuanlu Jiang
    • Chunsheng Kang

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, P.R. China, Laboratory of Neuro-Oncology, Tianjin Neurological Institute, 152 Ahshan Road, Heping, Tianjin 300052, P.R. China
  • Pages: 883-890
    |
    Published online on: June 29, 2011
       https://doi.org/10.3892/ijo.2011.1104
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Abstract

Increasing evidence suggests that interplays between Wnt/β-catenin and PI3K/AKT signaling cascades are involved in tumor development and progression. However, the exact mechanism in glioma is not well known. Using aspirin, we found that the expression levels of AKT1 in glioma cells significantly correlated with the transcriptional activity of β-catenin. Similar observations were made when we subjected glioma cells to treatment with Tcf4 siRNA. Moreover, both aspirin and Tcf4 siRNA can suppress the proliferation and induce apoptosis of glioma. In addition, our analysis of the gene promoter of AKT1 revealed multiple putative Tcf-4 binding sites. In support of the concept that β-catenin/Tcf-4 is a transcriptional regulator for AKT1, results from our chromatin immunoprecipitation studies and luciferase assay showed that β-catenin/Tcf-4 binds to the potential binding sites in the gene promoter of AKT1. Furthermore, using immunohistochemistry, we found that Tcf-4 protein expression increased significantly in high-grade glioma in comparison to low-grade glioma and correlated with AKT1 expression. In conclusion, our results support the concept that β-catenin/Tcf-4 directly regulates AKT1 in glioma, and these two proteins may cooperate with each other in exerting their oncogenic effects in glioma.

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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Huang K, Han L, Shi Z, Zhang K, Pu P, Jiang C and Kang C: β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma. Int J Oncol 39: 883-890, 2011.
APA
Chen, L., Huang, K., Han, L., Shi, Z., Zhang, K., Pu, P. ... Kang, C. (2011). β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma. International Journal of Oncology, 39, 883-890. https://doi.org/10.3892/ijo.2011.1104
MLA
Chen, L., Huang, K., Han, L., Shi, Z., Zhang, K., Pu, P., Jiang, C., Kang, C."β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma". International Journal of Oncology 39.4 (2011): 883-890.
Chicago
Chen, L., Huang, K., Han, L., Shi, Z., Zhang, K., Pu, P., Jiang, C., Kang, C."β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma". International Journal of Oncology 39, no. 4 (2011): 883-890. https://doi.org/10.3892/ijo.2011.1104
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Huang K, Han L, Shi Z, Zhang K, Pu P, Jiang C and Kang C: β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma. Int J Oncol 39: 883-890, 2011.
APA
Chen, L., Huang, K., Han, L., Shi, Z., Zhang, K., Pu, P. ... Kang, C. (2011). β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma. International Journal of Oncology, 39, 883-890. https://doi.org/10.3892/ijo.2011.1104
MLA
Chen, L., Huang, K., Han, L., Shi, Z., Zhang, K., Pu, P., Jiang, C., Kang, C."β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma". International Journal of Oncology 39.4 (2011): 883-890.
Chicago
Chen, L., Huang, K., Han, L., Shi, Z., Zhang, K., Pu, P., Jiang, C., Kang, C."β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma". International Journal of Oncology 39, no. 4 (2011): 883-890. https://doi.org/10.3892/ijo.2011.1104
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