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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2011 Volume 39 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2011 Volume 39 Issue 5

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Article

Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice

  • Authors:
    • Min Tian
    • Michelle L. Asp
    • Yoshinori Nishijima
    • Martha A. Belury

  • View Affiliations / Copyright

    Affiliations: Department of Human Nutrition, College of Education and Human Ecology, The Ohio State University, Columbus, OH, USA, Department of Human Nutrition, College of Education and Human Ecology, The Ohio State University, 1787 Neil Avenue, Columbus, OH, USA
  • Pages: 1321-1326
    |
    Published online on: August 5, 2011
       https://doi.org/10.3892/ijo.2011.1150
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Abstract

Cachexia is a common complication in cancer patients, which dramatically reduces quality of life and survival. In contrast to the well-studied feature of skeletal muscle loss, alterations in cardiac muscle are unclear. Recently, we reported that heart contractile function was significantly impaired in mice with colon-26 (C26) tumors, a widely used rodent model of cancer cachexia. In the present study, we investigated the potential underlying mechanisms for decreased heart function, specifically related to cardiac remodeling and atrophy. In cachectic mice bearing C26 tumors compared to mice without tumors, there was a gene expression pattern for cardiac remodeling, including increased BNP and c-fos, decreased PPARα and its responsive gene CPT1β, and a switch from ‘adult’ isoforms (MHCα, GLUT4) to ‘fetal’ isoforms (MHCβ and GLUT1). Echocardiography identified a decreased cardiac wall thickness. RT-PCR and Western blotting revealed a decreased amount of cardiac myofibrillar proteins MHC and troponin I, induced expression of E-3 ligases (MuRF-1 and Atrogin-1) and increased protein ubiquitination, providing evidence for cardiac atrophy in mice with cancer cachexia. Regulatory signaling pathways mediating these changes may include p44/42 MAPK. Together, these data provide evidence that pathways leading to cardiac remodeling and atrophy occur in mice with C26 cachexia.

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Copy and paste a formatted citation
Spandidos Publications style
Tian M, Asp ML, Nishijima Y and Belury MA: Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. Int J Oncol 39: 1321-1326, 2011.
APA
Tian, M., Asp, M.L., Nishijima, Y., & Belury, M.A. (2011). Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. International Journal of Oncology, 39, 1321-1326. https://doi.org/10.3892/ijo.2011.1150
MLA
Tian, M., Asp, M. L., Nishijima, Y., Belury, M. A."Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice". International Journal of Oncology 39.5 (2011): 1321-1326.
Chicago
Tian, M., Asp, M. L., Nishijima, Y., Belury, M. A."Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice". International Journal of Oncology 39, no. 5 (2011): 1321-1326. https://doi.org/10.3892/ijo.2011.1150
Copy and paste a formatted citation
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Spandidos Publications style
Tian M, Asp ML, Nishijima Y and Belury MA: Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. Int J Oncol 39: 1321-1326, 2011.
APA
Tian, M., Asp, M.L., Nishijima, Y., & Belury, M.A. (2011). Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. International Journal of Oncology, 39, 1321-1326. https://doi.org/10.3892/ijo.2011.1150
MLA
Tian, M., Asp, M. L., Nishijima, Y., Belury, M. A."Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice". International Journal of Oncology 39.5 (2011): 1321-1326.
Chicago
Tian, M., Asp, M. L., Nishijima, Y., Belury, M. A."Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice". International Journal of Oncology 39, no. 5 (2011): 1321-1326. https://doi.org/10.3892/ijo.2011.1150
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