Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver

  • Authors:
    • Jina Hong
    • Valerie B. Holcomb
    • Kyoko Kushiro
    • Nomelí P. Núñez
  • View Affiliations

  • Published online on: August 17, 2011     https://doi.org/10.3892/ijo.2011.1162
  • Pages: 1443-1453
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Abstract

The risk of developing breast cancer and fatty liver is increased by alcohol consumption. The objective of the present study was to determine if obesity and exogenous estrogen supplementation alter the effects of alcohol on mammary tumorigenesis and fatty liver. Ovariectomized female mice were (1) fed diets to induce overweight and obese phenotypes, (2) provided water or 20% alcohol, (3) implanted with placebo, low- or high-dose estrogen pellets and (4) injected with Met-1 mouse mammary cancer cells. Alcohol-consuming mice were more insulin sensitive and developed larger tumors than water consuming mice. Obese mice developed slightly larger tumors than control mice. Alcohol consumption and obesity increased growth factors, hepatic steatosis, activation of Akt, and inhibited the caspase-3 cascade. Estrogen treatment triggered the loss of body fat, induced insulin sensitivity, suppressed tumor growth, reduced growth factors and improved hepatic steatosis. Results show that the effects of alcohol on mammary tumor and fatty liver are modified by obesity and estrogen supplementation.

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December 2011
Volume 39 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hong J, Holcomb VB, Kushiro K and Núñez NP: Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver. Int J Oncol 39: 1443-1453, 2011.
APA
Hong, J., Holcomb, V.B., Kushiro, K., & Núñez, N.P. (2011). Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver. International Journal of Oncology, 39, 1443-1453. https://doi.org/10.3892/ijo.2011.1162
MLA
Hong, J., Holcomb, V. B., Kushiro, K., Núñez, N. P."Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver". International Journal of Oncology 39.6 (2011): 1443-1453.
Chicago
Hong, J., Holcomb, V. B., Kushiro, K., Núñez, N. P."Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver". International Journal of Oncology 39, no. 6 (2011): 1443-1453. https://doi.org/10.3892/ijo.2011.1162