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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2012 Volume 40 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2012 Volume 40 Issue 2

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Article

Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells

  • Authors:
    • Lilian Kadaja-Saarepuu
    • Marko Lõoke
    • Anna Balikova
    • Toivo Maimets
  • View Affiliations / Copyright

    Affiliations: Department of Cell Biology, Institute of Molecular and Cell Biology, University of Tartu, Riia Street 23, 51010 Tartu, Estonia
  • Pages: 567-576
    |
    Published online on: September 22, 2011
       https://doi.org/10.3892/ijo.2011.1208
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Abstract

CD43 (leukosialin, sialophorin), a cell surface protein on most hematopoietic cells, is an important regulator of immune cell function and is involved in regulation of cell adhesion and proliferation. Aberrant expression of CD43 is a common event observed in human tumors of non-hematopoietic origin suggesting a role in tumor development. We have previously shown that overexpression of CD43 causes activation of the ARF-p53 tumor-suppressor pathway and results in cell death. In a non-functional ARF-p53 background, the cells overexpressing CD43 display an increased cell growth rate due to higher survival. Here we show that p53 specifically downregulates the expression of CD43 at the protein and mRNA level. Transactivating properties of p53 are necessary to affect the expression of exogenous CD43. The downregulation of CD43 mRNA is caused by p53-dependent transrepression, at least in part, via a histone deacetylation mechanism. These studies establish that under certain conditions there exists a negative feedback loop between p53 and CD43: CD43-dependent signaling activates p53, which in turn downregulates the expression of CD43.

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Copy and paste a formatted citation
Spandidos Publications style
Kadaja-Saarepuu L, Lõoke M, Balikova A and Maimets T: Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. Int J Oncol 40: 567-576, 2012.
APA
Kadaja-Saarepuu, L., Lõoke, M., Balikova, A., & Maimets, T. (2012). Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. International Journal of Oncology, 40, 567-576. https://doi.org/10.3892/ijo.2011.1208
MLA
Kadaja-Saarepuu, L., Lõoke, M., Balikova, A., Maimets, T."Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells". International Journal of Oncology 40.2 (2012): 567-576.
Chicago
Kadaja-Saarepuu, L., Lõoke, M., Balikova, A., Maimets, T."Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells". International Journal of Oncology 40, no. 2 (2012): 567-576. https://doi.org/10.3892/ijo.2011.1208
Copy and paste a formatted citation
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Spandidos Publications style
Kadaja-Saarepuu L, Lõoke M, Balikova A and Maimets T: Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. Int J Oncol 40: 567-576, 2012.
APA
Kadaja-Saarepuu, L., Lõoke, M., Balikova, A., & Maimets, T. (2012). Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells. International Journal of Oncology, 40, 567-576. https://doi.org/10.3892/ijo.2011.1208
MLA
Kadaja-Saarepuu, L., Lõoke, M., Balikova, A., Maimets, T."Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells". International Journal of Oncology 40.2 (2012): 567-576.
Chicago
Kadaja-Saarepuu, L., Lõoke, M., Balikova, A., Maimets, T."Tumor suppressor p53 down-regulates expression of human leukocyte marker CD43 in non-hematopoietic tumor cells". International Journal of Oncology 40, no. 2 (2012): 567-576. https://doi.org/10.3892/ijo.2011.1208
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