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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2012 Volume 40 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2012 Volume 40 Issue 2

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Article

Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation

  • Authors:
    • Manish R. Patel
    • Ahad A. Sadiq
    • Joe Jay-Dixon
    • Tanawat Jirakulaporn
    • Blake A. Jacobson
    • Faris Farassati
    • Peter B. Bitterman
    • Robert A. Kratzke

  • View Affiliations / Copyright

    Affiliations: University of Minnesota Medical School, Division of Hematology, Oncology, and Transplantation, Minneapolis, MN, USA, Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, MMC 480, 420 Delaware St. SE, Minneapolis, MN 55455, USA
  • Pages: 577-582
    |
    Published online on: November 4, 2011
       https://doi.org/10.3892/ijo.2011.1252
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Abstract

Initiation of protein translation by the 5' mRNA cap is a tightly regulated step in cell growth and proliferation. Aberrant activation of cap-dependent translation is a hallmark of many cancers including non-small cell lung cancer. The canonical signaling mechanisms leading to translation initiation include activation of the Akt/mTOR pathway in response to the presence of nutrients and growth factors. We have previously observed that inhibition of c-jun N-terminal kinase (JNK) leads to inactivation of cap-dependent translation in mesothelioma cells. Since JNK is involved in the genesis of non-small cell lung cancer (NSCLC), we hypothesized that JNK could also be involved in activating cap-dependent translation in NSCLC cells and could represent an alternative pathway regulating translation. In a series of NSCLC cell lines, inhibition of JNK using SP600125 resulted in inhibition of 4E-BP1 phosphorylation and a decrease in formation of the cap-dependent translation complex, eIF4F. Furthermore, we show that JNK-mediated inhibition of translation is independent of mTOR. Our data provide evidence that JNK is involved in the regulation of translation and has potential as a therapeutic target in NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Patel MR, Sadiq AA, Jay-Dixon J, Jirakulaporn T, Jacobson BA, Farassati F, Bitterman PB and Kratzke RA: Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. Int J Oncol 40: 577-582, 2012.
APA
Patel, M.R., Sadiq, A.A., Jay-Dixon, J., Jirakulaporn, T., Jacobson, B.A., Farassati, F. ... Kratzke, R.A. (2012). Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. International Journal of Oncology, 40, 577-582. https://doi.org/10.3892/ijo.2011.1252
MLA
Patel, M. R., Sadiq, A. A., Jay-Dixon, J., Jirakulaporn, T., Jacobson, B. A., Farassati, F., Bitterman, P. B., Kratzke, R. A."Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation". International Journal of Oncology 40.2 (2012): 577-582.
Chicago
Patel, M. R., Sadiq, A. A., Jay-Dixon, J., Jirakulaporn, T., Jacobson, B. A., Farassati, F., Bitterman, P. B., Kratzke, R. A."Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation". International Journal of Oncology 40, no. 2 (2012): 577-582. https://doi.org/10.3892/ijo.2011.1252
Copy and paste a formatted citation
x
Spandidos Publications style
Patel MR, Sadiq AA, Jay-Dixon J, Jirakulaporn T, Jacobson BA, Farassati F, Bitterman PB and Kratzke RA: Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. Int J Oncol 40: 577-582, 2012.
APA
Patel, M.R., Sadiq, A.A., Jay-Dixon, J., Jirakulaporn, T., Jacobson, B.A., Farassati, F. ... Kratzke, R.A. (2012). Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation. International Journal of Oncology, 40, 577-582. https://doi.org/10.3892/ijo.2011.1252
MLA
Patel, M. R., Sadiq, A. A., Jay-Dixon, J., Jirakulaporn, T., Jacobson, B. A., Farassati, F., Bitterman, P. B., Kratzke, R. A."Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation". International Journal of Oncology 40.2 (2012): 577-582.
Chicago
Patel, M. R., Sadiq, A. A., Jay-Dixon, J., Jirakulaporn, T., Jacobson, B. A., Farassati, F., Bitterman, P. B., Kratzke, R. A."Novel role of c-jun N-terminal kinase in regulating the initiation of cap-dependent translation". International Journal of Oncology 40, no. 2 (2012): 577-582. https://doi.org/10.3892/ijo.2011.1252
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