Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells

  • Authors:
    • Su-Hwa Kim
    • Eun-Jung Park
    • Chae Ryun Lee
    • Jung Nyeo Chun
    • Nam-Hyuk Cho
    • In-Gyu Kim
    • Sanghoon Lee
    • Tae Woo Kim
    • Hyun Ho Park
    • Insuk So
    • Ju-Hong Jeon
  • View Affiliations

  • Published online on: December 23, 2011     https://doi.org/10.3892/ijo.2011.1318
  • Pages: 1683-1690
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Abstract

Geraniol, an acyclic dietary monoterpene, suppresses prostate cancer growth and enhances docetaxel chemosensitivity in cultured cell or xenograft tumor models. However, the mechanisms of the geraniol action against prostate cancer are largely unknown. In this study, we investigated the cellular and molecular mechanisms of geraniol-induced cell death in PC-3 prostate cancer cells. Among the examined structurally and functionally similar monoterpenes, geraniol potently induced apoptosis and autophagy. Although independent processes, apoptosis and autophagy acted as cooperative partners to elicit geraniol-induced cell death in PC-3 cells. At a molecular level, geraniol inhibited AKT signaling and activated AMPK signaling, resulting in mTOR inhibition. Combined treatment of AKT inhibitor and AMPK activator markedly suppressed cell growth compared to either treatment alone. Our findings provide insight into future investigations that are aimed at elucidating the role of apoptosis and autophagy in prostate cancer therapy and at developing anticancer strategies co-targeting AKT and AMPK.

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May 2012
Volume 40 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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APA
Kim, S., Park, E., Lee, C.R., Chun, J.N., Cho, N., Kim, I. ... Jeon, J. (2012). Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells. International Journal of Oncology, 40, 1683-1690. https://doi.org/10.3892/ijo.2011.1318
MLA
Kim, S., Park, E., Lee, C. R., Chun, J. N., Cho, N., Kim, I., Lee, S., Kim, T. W., Park, H. H., So, I., Jeon, J."Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells". International Journal of Oncology 40.5 (2012): 1683-1690.
Chicago
Kim, S., Park, E., Lee, C. R., Chun, J. N., Cho, N., Kim, I., Lee, S., Kim, T. W., Park, H. H., So, I., Jeon, J."Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC-3 prostate cancer cells". International Journal of Oncology 40, no. 5 (2012): 1683-1690. https://doi.org/10.3892/ijo.2011.1318