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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2012 Volume 40 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2012 Volume 40 Issue 5

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Article

Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells

  • Authors:
    • Soon-Kyung Hwang
    • Arash Minai-Tehrani
    • Kyeong-Nam Yu
    • Seung-Hee Chang
    • Ji-Eun Kim
    • Kee-Ho Lee
    • Jongsun Park
    • George R. Beck
    • Myung-Haing Cho

  • View Affiliations / Copyright

    Affiliations: Laboratory of Toxicology, College of Veterinary Medicine Seoul National University, Seoul 151-742, Republic of Korea, Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea
  • Pages: 1515-1524
    |
    Published online on: December 23, 2011
       https://doi.org/10.3892/ijo.2011.1319
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Abstract

Serine/threonine protein kinase B (PKB/Akt) is involved in cell survival and growth. Carboxyl-terminal modulator protein (CTMP), a novel Akt binding partner, prevents Akt activation at the plasma membrane in response to various stimuli, and thus possesses a tumor suppressor-like function. In a previous study, we have demonstrated that CTMP inhibits tumor progression by facilitating apoptosis in a mouse lung cancer model. However, the precise mechanism of CTMP-induced apoptosis remains to be elucidated. The present study was performed to examine the role of CTMP in mitochondrial-mediated apoptosis and regulation of mitochondrial function in human lung carcinoma cells. Our results showed that CTMP altered mitochondrial morphology and caused the release of cytochrome c by inhibiting OPA1 expression. Additionally, CTMP facilitated mitochondrial-mediated apoptosis by inhibiting heat-shock protein 27 and preventing cytochrome c interaction with Apaf-1. Our data suggest that CTMP may therefore play a critical role in mitochondrial-mediated apoptosis in lung cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Hwang S, Minai-Tehrani A, Yu K, Chang S, Kim J, Lee K, Park J, Beck GR and Cho M: Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. Int J Oncol 40: 1515-1524, 2012.
APA
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K. ... Cho, M. (2012). Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. International Journal of Oncology, 40, 1515-1524. https://doi.org/10.3892/ijo.2011.1319
MLA
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K., Park, J., Beck , G. R., Cho, M."Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells". International Journal of Oncology 40.5 (2012): 1515-1524.
Chicago
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K., Park, J., Beck , G. R., Cho, M."Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells". International Journal of Oncology 40, no. 5 (2012): 1515-1524. https://doi.org/10.3892/ijo.2011.1319
Copy and paste a formatted citation
x
Spandidos Publications style
Hwang S, Minai-Tehrani A, Yu K, Chang S, Kim J, Lee K, Park J, Beck GR and Cho M: Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. Int J Oncol 40: 1515-1524, 2012.
APA
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K. ... Cho, M. (2012). Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. International Journal of Oncology, 40, 1515-1524. https://doi.org/10.3892/ijo.2011.1319
MLA
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K., Park, J., Beck , G. R., Cho, M."Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells". International Journal of Oncology 40.5 (2012): 1515-1524.
Chicago
Hwang, S., Minai-Tehrani, A., Yu, K., Chang, S., Kim, J., Lee, K., Park, J., Beck , G. R., Cho, M."Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells". International Journal of Oncology 40, no. 5 (2012): 1515-1524. https://doi.org/10.3892/ijo.2011.1319
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