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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2011 Volume 38 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2011 Volume 38 Issue 3

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Article

Circulating melanoma cells and survival in metastatic melanoma

  • Authors:
    • C. Rao
    • T. Bui
    • M. Connelly
    • G. Doyle
    • I. Karydis
    • M. R. Middleton
    • G. Clack
    • M. Malone
    • F. A.W. Coumans
    • L.W. M.M. Terstappen

  • View Affiliations / Copyright

    Affiliations: Veridex LLC, Huntingdon Valley, PA, USA, University of Twente, Faculty of Science and Technology, MIRA institute, Department of Medical Cell BioPhysics, Building Care, P.O. Box 217, 7500 AE Enschede, The Netherlands
  • Pages: 755-760
    |
    Published online on: January 3, 2011
       https://doi.org/10.3892/ijo.2011.896
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Abstract

A validated assay for the enumeration of circulating melanoma cells (CMCs) may facilitate the development of more effective therapies for metastatic melanoma patients. In this study CD146+ cells were immunomagnetically enriched from 7.5 ml of blood. Isolated cells were fluorescently stained with DAPI, anti-molecular weight melanoma-associated antigen (HMW-MAA), anti-CD45 and CD34 and Ki67. CMCs were identified as CD146+, HMW-MAA+, CD45-, CD34-, Ki67-/+ cells. Eighty-eight percent of spiked SK-MEL28 cells in 7.5 ml blood were recovered. In all 55 healthy donors ≤1 CMCs were detected in 7.5 ml of blood. A retrospective analysis was conducted comparing CMC counts and overall survival in 79 blood samples from 44 melanoma patients. CMCs ranged from 0 to 8,042 per 7.5 ml. Two or more CMCs were detected in 18 (23%) of the patients and 30-100% (mean 84%) of the CMCs expressed the proliferation marker Ki67. Patients with ≥2 CMCs per 7.5 ml of whole blood, as compared with the group with <2 CMCs, had a shorter overall survival (2.0 months vs. 12.1 months, P=0.001).

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Copy and paste a formatted citation
Spandidos Publications style
Rao C, Bui T, Connelly M, Doyle G, Karydis I, Middleton MR, Clack G, Malone M, Coumans FA, Terstappen LM, Terstappen LM, et al: Circulating melanoma cells and survival in metastatic melanoma. Int J Oncol 38: 755-760, 2011.
APA
Rao, C., Bui, T., Connelly, M., Doyle, G., Karydis, I., Middleton, M.R. ... Terstappen, L.M. (2011). Circulating melanoma cells and survival in metastatic melanoma. International Journal of Oncology, 38, 755-760. https://doi.org/10.3892/ijo.2011.896
MLA
Rao, C., Bui, T., Connelly, M., Doyle, G., Karydis, I., Middleton, M. R., Clack, G., Malone, M., Coumans, F. A., Terstappen, L. M."Circulating melanoma cells and survival in metastatic melanoma". International Journal of Oncology 38.3 (2011): 755-760.
Chicago
Rao, C., Bui, T., Connelly, M., Doyle, G., Karydis, I., Middleton, M. R., Clack, G., Malone, M., Coumans, F. A., Terstappen, L. M."Circulating melanoma cells and survival in metastatic melanoma". International Journal of Oncology 38, no. 3 (2011): 755-760. https://doi.org/10.3892/ijo.2011.896
Copy and paste a formatted citation
x
Spandidos Publications style
Rao C, Bui T, Connelly M, Doyle G, Karydis I, Middleton MR, Clack G, Malone M, Coumans FA, Terstappen LM, Terstappen LM, et al: Circulating melanoma cells and survival in metastatic melanoma. Int J Oncol 38: 755-760, 2011.
APA
Rao, C., Bui, T., Connelly, M., Doyle, G., Karydis, I., Middleton, M.R. ... Terstappen, L.M. (2011). Circulating melanoma cells and survival in metastatic melanoma. International Journal of Oncology, 38, 755-760. https://doi.org/10.3892/ijo.2011.896
MLA
Rao, C., Bui, T., Connelly, M., Doyle, G., Karydis, I., Middleton, M. R., Clack, G., Malone, M., Coumans, F. A., Terstappen, L. M."Circulating melanoma cells and survival in metastatic melanoma". International Journal of Oncology 38.3 (2011): 755-760.
Chicago
Rao, C., Bui, T., Connelly, M., Doyle, G., Karydis, I., Middleton, M. R., Clack, G., Malone, M., Coumans, F. A., Terstappen, L. M."Circulating melanoma cells and survival in metastatic melanoma". International Journal of Oncology 38, no. 3 (2011): 755-760. https://doi.org/10.3892/ijo.2011.896
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