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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2011 Volume 38 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2011 Volume 38 Issue 4

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Article

Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma

  • Authors:
    • Xiaofei Chang
    • Keishi Yamashita
    • David Sidransky
    • Myoung Sook Kim
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Cancer Research Division, The Johns Hopkins University, School of Medicine, 1550 Orleans Street, CRB II-5M, Baltimore, MD 21231, USA
  • Pages: 1129-1135
    |
    Published online on: January 21, 2011
       https://doi.org/10.3892/ijo.2011.918
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Abstract

Hypermethylation of gene promoters and the corresponding loss of gene expression are recognized as a hallmark of human cancer, and DNA methylation has emerged as a promising biomarker for the detection of human esophageal squamous cell carcinoma (ESCC). To identify novel genes methylated in ESCC, we screened 35 candidate genes identified from an oligonucleotide microarray. Among them, the heat shock protein B2 (HSPB2) was methylated in 95.7% (67/70) of primary ESCCs, whereas no methylation was found in normal esophageal tissues from ESCC patients (0%, 0/20). RT-PCR analysis revealed that HSPB2 expression was silenced or weakly expressed in most ESCC cell lines, and re-activated by the demethylating agent 5-aza-2'-deoxy-cytidine. These results indicate that promoter methylation of HSPB2 is one of the causal factors for loss or down-regulation of HSPB2 expression. mRNA expression of HSPB2 in ESCC tissues was significantly down-regulated compared to normal tissues. Our data suggest that promoter methylation of HSPB2 deserves further attention as a novel molecular biomarker in human ESCC.

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Copy and paste a formatted citation
Spandidos Publications style
Chang X, Yamashita K, Sidransky D and Kim MS: Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma. Int J Oncol 38: 1129-1135, 2011.
APA
Chang, X., Yamashita, K., Sidransky, D., & Kim, M.S. (2011). Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma. International Journal of Oncology, 38, 1129-1135. https://doi.org/10.3892/ijo.2011.918
MLA
Chang, X., Yamashita, K., Sidransky, D., Kim, M. S."Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma". International Journal of Oncology 38.4 (2011): 1129-1135.
Chicago
Chang, X., Yamashita, K., Sidransky, D., Kim, M. S."Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma". International Journal of Oncology 38, no. 4 (2011): 1129-1135. https://doi.org/10.3892/ijo.2011.918
Copy and paste a formatted citation
x
Spandidos Publications style
Chang X, Yamashita K, Sidransky D and Kim MS: Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma. Int J Oncol 38: 1129-1135, 2011.
APA
Chang, X., Yamashita, K., Sidransky, D., & Kim, M.S. (2011). Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma. International Journal of Oncology, 38, 1129-1135. https://doi.org/10.3892/ijo.2011.918
MLA
Chang, X., Yamashita, K., Sidransky, D., Kim, M. S."Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma". International Journal of Oncology 38.4 (2011): 1129-1135.
Chicago
Chang, X., Yamashita, K., Sidransky, D., Kim, M. S."Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma". International Journal of Oncology 38, no. 4 (2011): 1129-1135. https://doi.org/10.3892/ijo.2011.918
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