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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2011 Volume 38 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2011 Volume 38 Issue 5

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Article

Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin

  • Authors:
    • Sufen Zhao
    • Gang Ye
    • Guodong Fu
    • Jian-Xin Cheng
    • Burton B. Yang
    • Chun Peng

  • View Affiliations / Copyright

    Affiliations: Department of Biology, York University, Toronto, Canada, Department of Biology, York University, 4700 Keel Street, Toronto, ON M3J 1P3, Canada
  • Pages: 1319-1327
    |
    Published online on: March 8, 2011
       https://doi.org/10.3892/ijo.2011.965
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Abstract

Ganoderma lucidum is a herbal mushroom known to have many health benefits, including the inhibition of tumor cell growth. However, the effect of Ganoderma lucidum on epithelial ovarian cancer (EOC), the most fatal gynecological malignancy, has not yet been reported. In this study, we determined whether Ganoderma lucidum regulates EOC cell activity. Using several cell lines derived from EOC, we found that Ganoderma lucidum strongly decreased cell numbers in a dose-dependent manner. Ganoderma lucidum also inhibited colony formation, cell migration and spheroid formation. In particular, Ganoderma lucidum was effective in inhibiting cell growth in both chemosensitive and chemoresistant cells and the treatment with Ganoderma lucidum significantly enhanced the effect of cisplatin on EOC cells. Furthermore, Ganoderma lucidum induced cell cycle arrest at the G2/M phase and also induced apoptosis by activating caspase 3. Finally, Ganoderma lucidum increased p53 but inhibited Akt expression. Taken together, these findings suggest that Ganoderma lucidum exerts multiple anti-tumor effects on ovarian cancer cells and can enhance the sensitivity of EOC cells to cisplatin.

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Copy and paste a formatted citation
Spandidos Publications style
Zhao S, Ye G, Fu G, Cheng J, Yang BB and Peng C: Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol 38: 1319-1327, 2011.
APA
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B.B., & Peng, C. (2011). Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. International Journal of Oncology, 38, 1319-1327. https://doi.org/10.3892/ijo.2011.965
MLA
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B. B., Peng, C."Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin". International Journal of Oncology 38.5 (2011): 1319-1327.
Chicago
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B. B., Peng, C."Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin". International Journal of Oncology 38, no. 5 (2011): 1319-1327. https://doi.org/10.3892/ijo.2011.965
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao S, Ye G, Fu G, Cheng J, Yang BB and Peng C: Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. Int J Oncol 38: 1319-1327, 2011.
APA
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B.B., & Peng, C. (2011). Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin. International Journal of Oncology, 38, 1319-1327. https://doi.org/10.3892/ijo.2011.965
MLA
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B. B., Peng, C."Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin". International Journal of Oncology 38.5 (2011): 1319-1327.
Chicago
Zhao, S., Ye, G., Fu, G., Cheng, J., Yang, B. B., Peng, C."Ganoderma lucidum exerts anti-tumor effects on ovarian cancer cells and enhances their sensitivity to cisplatin". International Journal of Oncology 38, no. 5 (2011): 1319-1327. https://doi.org/10.3892/ijo.2011.965
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