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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2011 Volume 38 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2011 Volume 38 Issue 6

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Article

Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis

  • Authors:
    • Wenwen Chien
    • James O'Kelly
    • Daning Lu
    • Amanda Leiter
    • Julia Sohn
    • Dong  Yin
    • Beth Karlan
    • Jay Vadgama
    • Karen M. Lyons
    • H. Phillip Koeffler

  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA
  • Pages: 1741-1747
    |
    Published online on: March 23, 2011
       https://doi.org/10.3892/ijo.2011.985
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Abstract

Connective tissue growth factor (CTGF/CCN2) belongs to the CCN family of matricellular proteins, comprising Cyr61, CTGF, NovH and WISP1-3. The CCN proteins contain an N-terminal signal peptide followed by four conserved domains sharing sequence similarities with the insulin-like growth factor binding proteins, von Willebrand factor type C repeat, thrombospondin type 1 repeat, and a C-terminal growth factor cysteine knot domain. To investigate the role of CCN2 in breast cancer, we transfected MCF-7 cells with full-length CCN2, and with four mutant constructs in which one of the domains had been deleted. MCF-7 cells stably expressing full-length CCN2 demonstrated reduced cell proliferation, increased migration in Boyden chamber assays and promoted angiogenesis in chorioallantoic membrane assays compared to control cells. Deletion of the C-terminal cysteine knot domain, but not of any other domain-deleted mutants, abolished activities mediated by full-length CCN2. We have dissected the role of CCN2 in breast tumorigenesis on a structural basis.

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Copy and paste a formatted citation
Spandidos Publications style
Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP, Koeffler HP, et al: Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol 38: 1741-1747, 2011.
APA
Chien, W., O'Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D. ... Koeffler, H.P. (2011). Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. International Journal of Oncology, 38, 1741-1747. https://doi.org/10.3892/ijo.2011.985
MLA
Chien, W., O'Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D., Karlan, B., Vadgama, J., Lyons, K. M., Koeffler, H. P."Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis". International Journal of Oncology 38.6 (2011): 1741-1747.
Chicago
Chien, W., O'Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D., Karlan, B., Vadgama, J., Lyons, K. M., Koeffler, H. P."Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis". International Journal of Oncology 38, no. 6 (2011): 1741-1747. https://doi.org/10.3892/ijo.2011.985
Copy and paste a formatted citation
x
Spandidos Publications style
Chien W, O'Kelly J, Lu D, Leiter A, Sohn J, Yin D, Karlan B, Vadgama J, Lyons KM, Koeffler HP, Koeffler HP, et al: Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. Int J Oncol 38: 1741-1747, 2011.
APA
Chien, W., O'Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D. ... Koeffler, H.P. (2011). Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis. International Journal of Oncology, 38, 1741-1747. https://doi.org/10.3892/ijo.2011.985
MLA
Chien, W., O'Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D., Karlan, B., Vadgama, J., Lyons, K. M., Koeffler, H. P."Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis". International Journal of Oncology 38.6 (2011): 1741-1747.
Chicago
Chien, W., O'Kelly, J., Lu, D., Leiter, A., Sohn, J., Yin, D., Karlan, B., Vadgama, J., Lyons, K. M., Koeffler, H. P."Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis". International Journal of Oncology 38, no. 6 (2011): 1741-1747. https://doi.org/10.3892/ijo.2011.985
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