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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2012 Volume 40 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article Open Access

Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach

  • Authors:
    • George I. Lambrou
    • Apostolos Zaravinos
    • Maria Adamaki
    • Demetrios  A. Spandidos
    • Fotini Tzortzatou-Stathopoulou
    • Spiros Vlachopoulos

  • View Affiliations / Copyright

    Affiliations: First Department of Pediatrics, Choremeio Research Laboratory, University of Athens, Athens 11527, Greece, Laboratory of Virology, Medical School, University of Crete, Heraklion 71110, Crete, Greece
  • Pages: 1365-1390
    |
    Published online on: February 7, 2012
       https://doi.org/10.3892/ijo.2012.1361
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Abstract

A part of current research has intensively been focused on the proliferation and metabolic processes governing biological systems. Since the advent of high throughput methodologies such as microarrays, the load of genomic data has increased geometrically and along with that the need for computational methods to interpret these data. In the present study, we investigated in vitro the common proliferation and metabolic processes, associated with common oncogenic pathways, as far as gene expression is concerned, between the T-cell acute lymphoblastic leukemia (CCRF-CEM) and the rhabdomyosarcoma (TE-671) cell lines. We present a computational approach, using cDNA microarrays, in order to identify commonalities between diverse biological systems. Our analysis predicted that JAK1, STAT1, PIAS2 and CDK4 are the driving forces in the two cell lines. This type of analysis may lead to the understanding of the common mechanisms that transform physiological cells to malignant, and may reveal a new holistic approach to understanding the dynamics of tumor onset as well as the mechanistics behind oncogenic drivers.

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Copy and paste a formatted citation
Spandidos Publications style
Lambrou GI, Zaravinos A, Adamaki M, Spandidos DA, Tzortzatou-Stathopoulou F and Vlachopoulos S: Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach. Int J Oncol 40: 1365-1390, 2012.
APA
Lambrou, G.I., Zaravinos, A., Adamaki, M., Spandidos, D.A., Tzortzatou-Stathopoulou, F., & Vlachopoulos, S. (2012). Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach. International Journal of Oncology, 40, 1365-1390. https://doi.org/10.3892/ijo.2012.1361
MLA
Lambrou, G. I., Zaravinos, A., Adamaki, M., Spandidos, D. A., Tzortzatou-Stathopoulou, F., Vlachopoulos, S."Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach". International Journal of Oncology 40.5 (2012): 1365-1390.
Chicago
Lambrou, G. I., Zaravinos, A., Adamaki, M., Spandidos, D. A., Tzortzatou-Stathopoulou, F., Vlachopoulos, S."Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach". International Journal of Oncology 40, no. 5 (2012): 1365-1390. https://doi.org/10.3892/ijo.2012.1361
Copy and paste a formatted citation
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Spandidos Publications style
Lambrou GI, Zaravinos A, Adamaki M, Spandidos DA, Tzortzatou-Stathopoulou F and Vlachopoulos S: Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach. Int J Oncol 40: 1365-1390, 2012.
APA
Lambrou, G.I., Zaravinos, A., Adamaki, M., Spandidos, D.A., Tzortzatou-Stathopoulou, F., & Vlachopoulos, S. (2012). Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach. International Journal of Oncology, 40, 1365-1390. https://doi.org/10.3892/ijo.2012.1361
MLA
Lambrou, G. I., Zaravinos, A., Adamaki, M., Spandidos, D. A., Tzortzatou-Stathopoulou, F., Vlachopoulos, S."Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach". International Journal of Oncology 40.5 (2012): 1365-1390.
Chicago
Lambrou, G. I., Zaravinos, A., Adamaki, M., Spandidos, D. A., Tzortzatou-Stathopoulou, F., Vlachopoulos, S."Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: A systems biology approach". International Journal of Oncology 40, no. 5 (2012): 1365-1390. https://doi.org/10.3892/ijo.2012.1361
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