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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2012 Volume 40 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2012 Volume 40 Issue 6

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Review Open Access

Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)

  • Authors:
    • Kouji Banno
    • Iori Kisu
    • Megumi Yanokura
    • Kosuke Tsuji
    • Kenta Masuda
    • Arisa Ueki
    • Yusuke Kobayashi
    • Wataru Yamagami
    • Hiroyuki Nomura
    • Nobuyuki Susumu
    • Daisuke Aoki

  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan
  • Pages: 1755-1762
    |
    Published online on: February 21, 2012
       https://doi.org/10.3892/ijo.2012.1384
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Abstract

Progestin preparations are made of synthetic progesterone and have often been used for hormone therapy in gynecological patients with endometriosis or endometrial cancer. Hormone therapy using progestin is considered to be one of the effective means of treatment particularly when dealing with endometrial cancer (an estrogen-dependent tumor). Numerous reports have been published concerning its efficacy in advanced or recurrent cases of atypical endometrial hyperplasia or endometrial cancer. Dienogest has been developed as a fourth-generation progestin for hormone therapy for endometriosis that can be used with high safety for long periods of time. In Japan, dienogest has been recommended as a first-line drug for endometriosis-associated pain. However, its antitumor activity has also been attracting close attention following a report that this drug suppressed the proliferation in vitro of endometrial cancer-derived cell lines which failed to respond to other progestins such as medroxyprogesterine acetate (MPA). The mechanism for antitumor activity of dienogest is considered to differ from the mechanism for antitumor activity of conventional progestin preparations used for treatment of endometrial cancer. This drug is expected to be clinically applicable as a new drug for the treatment of endometrial cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Susumu N, Susumu N, et al: Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review). Int J Oncol 40: 1755-1762, 2012.
APA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A. ... Aoki, D. (2012). Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review). International Journal of Oncology, 40, 1755-1762. https://doi.org/10.3892/ijo.2012.1384
MLA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., Aoki, D."Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)". International Journal of Oncology 40.6 (2012): 1755-1762.
Chicago
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., Aoki, D."Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)". International Journal of Oncology 40, no. 6 (2012): 1755-1762. https://doi.org/10.3892/ijo.2012.1384
Copy and paste a formatted citation
x
Spandidos Publications style
Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Susumu N, Susumu N, et al: Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review). Int J Oncol 40: 1755-1762, 2012.
APA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A. ... Aoki, D. (2012). Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review). International Journal of Oncology, 40, 1755-1762. https://doi.org/10.3892/ijo.2012.1384
MLA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., Aoki, D."Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)". International Journal of Oncology 40.6 (2012): 1755-1762.
Chicago
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., Aoki, D."Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)". International Journal of Oncology 40, no. 6 (2012): 1755-1762. https://doi.org/10.3892/ijo.2012.1384
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