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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2012 Volume 40 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2012 Volume 40 Issue 6

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Article

A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures

  • Authors:
    • Susan J. Turrell
    • Stuart A. Macnab
    • Ailsa Rose
    • Alan A. Melcher
    • Adrian Whitehouse

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK, Cancer Research UK, Leeds Institute of Molecular Medicine, St. James' University Hospital, Leeds, LS9 7TF, UK
  • Pages: 2081-2089
    |
    Published online on: March 1, 2012
       https://doi.org/10.3892/ijo.2012.1394
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Abstract

Herpesvirus saimiri (HVS) is capable of infecting a range of human carcinoma cell types with high efficiency and the viral genome persists as high copy number, circular, non-integrated episomes which segregate to progeny upon cell division. This allows HVS-based vectors to stably transduce a dividing cell population and provide sustained transgene expression for an extended period of time both in vitro and in vivo. Moreover, the insertion of a bacterial artificial chromosome cassette into the HVS genome simplifies the incorporation of large amounts of heterologous DNA for gene delivery. Herein we have produced a recombinant HVS-based vector containing full-length human TRAIL under the control of the α-survivin promoter, and subsequently challenged a variety of cancer cell lines with this vector. The TRAIL transgene was expressed in infected colorectal SW480 cells, causing considerable apoptosis induction. Apoptosis was also observed when several other cancer cell lines derived from different tissues were infected. Moreover, co-treatment with Jak inhibitor AG490 led to the disruption of spheroid cultures grown from the melanoma Mel888 line. These data suggest that an HVS gene therapy vector expressing TRAIL could be an effective treatment against cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Turrell SJ, Macnab SA, Rose A, Melcher AA and Whitehouse A: A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures. Int J Oncol 40: 2081-2089, 2012.
APA
Turrell, S.J., Macnab, S.A., Rose, A., Melcher, A.A., & Whitehouse, A. (2012). A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures. International Journal of Oncology, 40, 2081-2089. https://doi.org/10.3892/ijo.2012.1394
MLA
Turrell, S. J., Macnab, S. A., Rose, A., Melcher, A. A., Whitehouse, A."A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures". International Journal of Oncology 40.6 (2012): 2081-2089.
Chicago
Turrell, S. J., Macnab, S. A., Rose, A., Melcher, A. A., Whitehouse, A."A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures". International Journal of Oncology 40, no. 6 (2012): 2081-2089. https://doi.org/10.3892/ijo.2012.1394
Copy and paste a formatted citation
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Spandidos Publications style
Turrell SJ, Macnab SA, Rose A, Melcher AA and Whitehouse A: A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures. Int J Oncol 40: 2081-2089, 2012.
APA
Turrell, S.J., Macnab, S.A., Rose, A., Melcher, A.A., & Whitehouse, A. (2012). A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures. International Journal of Oncology, 40, 2081-2089. https://doi.org/10.3892/ijo.2012.1394
MLA
Turrell, S. J., Macnab, S. A., Rose, A., Melcher, A. A., Whitehouse, A."A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures". International Journal of Oncology 40.6 (2012): 2081-2089.
Chicago
Turrell, S. J., Macnab, S. A., Rose, A., Melcher, A. A., Whitehouse, A."A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures". International Journal of Oncology 40, no. 6 (2012): 2081-2089. https://doi.org/10.3892/ijo.2012.1394
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