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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2012 Volume 40 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2012 Volume 40 Issue 6

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Article

Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors

  • Authors:
    • Teong Lip Chuah
    • David Gregory Walker
    • Ming Wei
    • Shaun Scott
    • Martin Francis Lavin

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, University of Queensland, St. Lucia, Queensland, Australia, Gene Therapy Unit, Prince Charles Hospital, Chermside, Queensland, Australia, Radiation Biology and Oncology Unit, Queensland Institute of Medical Research, Herston, Queensland, Australia , Radiation Biology and Oncology Unit, Queensland Institute of Medical Research, Herston, Queensland, Australia
  • Pages: 1963-1969
    |
    Published online on: March 22, 2012
       https://doi.org/10.3892/ijo.2012.1409
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Abstract

Glioblastoma multiforme (GBM) is the most common primary brain tumour and extirpation followed by radio- and chemotherapy has had minimal impact on the median survival of patients which is still less than one year. Hence, a novel therapeutic modality is required if the survival of patients with this disease is to be improved. ATM, mutated in the human genetic disorder ataxia-telangiectasia (A-T), plays a central role in the response to DNA double strand breaks and patients with this disorder are characterised by extreme sensitivity to radiation, increased risk of cancer and neurodegeneration. Thus, ATM represents a potential target for radiosensitization of brain tumour cells. A safe, non-replicating lentivirus is used to abrogate ATM in GBM through the antisense and RNAi approaches for radiosensitization. With either techniques, ATM protein was reduced by >90% and there was a 3‑fold sensitization of GBM cells to radiation. ATM protein activation as well as ATM pS1981 foci formation were defective and downstream signalling determined by Ser15 phosphorylation on p53 was reduced. Success in the approaches provides a novel and exciting strategy for the treatment of GBM and thus improving the survival of patients with these tumours.

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Copy and paste a formatted citation
Spandidos Publications style
Chuah TL, Walker DG, Wei M, Scott S and Lavin MF: Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors. Int J Oncol 40: 1963-1969, 2012.
APA
Chuah, T.L., Walker, D.G., Wei, M., Scott, S., & Lavin, M.F. (2012). Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors. International Journal of Oncology, 40, 1963-1969. https://doi.org/10.3892/ijo.2012.1409
MLA
Chuah, T. L., Walker, D. G., Wei, M., Scott, S., Lavin, M. F."Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors". International Journal of Oncology 40.6 (2012): 1963-1969.
Chicago
Chuah, T. L., Walker, D. G., Wei, M., Scott, S., Lavin, M. F."Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors". International Journal of Oncology 40, no. 6 (2012): 1963-1969. https://doi.org/10.3892/ijo.2012.1409
Copy and paste a formatted citation
x
Spandidos Publications style
Chuah TL, Walker DG, Wei M, Scott S and Lavin MF: Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors. Int J Oncol 40: 1963-1969, 2012.
APA
Chuah, T.L., Walker, D.G., Wei, M., Scott, S., & Lavin, M.F. (2012). Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors. International Journal of Oncology, 40, 1963-1969. https://doi.org/10.3892/ijo.2012.1409
MLA
Chuah, T. L., Walker, D. G., Wei, M., Scott, S., Lavin, M. F."Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors". International Journal of Oncology 40.6 (2012): 1963-1969.
Chicago
Chuah, T. L., Walker, D. G., Wei, M., Scott, S., Lavin, M. F."Approaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors". International Journal of Oncology 40, no. 6 (2012): 1963-1969. https://doi.org/10.3892/ijo.2012.1409
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