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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2012 Volume 41 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2012 Volume 41 Issue 1

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Article Open Access

Antiproliferative effect of oleuropein in prostate cell lines

  • Authors:
    • Rosaria Acquaviva
    • Claudia Di Giacomo
    • Valeria Sorrenti
    • Fabio Galvano
    • Rosa Santangelo
    • Venera Cardile
    • Silvia Gangia
    • Nicolantonio D'Orazio
    • Nader G. Abraham
    • Luca Vanella

  • View Affiliations / Copyright

    Affiliations: Department of Drug Sciences, Section of Biochemistry, University of Catania, I-95125 Catania, Italy, Department of Bio-Medical Sciences, Section of Physiology, University of Catania, I-95125 Catania, Italy, Department of Biochemistry, Human Nutrition Unit, University of Chieti, Chieti, Italy, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA
  • Pages: 31-38
    |
    Published online on: April 5, 2012
       https://doi.org/10.3892/ijo.2012.1428
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Abstract

Currently, there is increasing interest in the in vivo protective effects of natural antioxidants found in dietary plants against oxidative damage caused by free radical species. Oxidative stress has been invoked as a causative agent in cancer and epidemiological data suggest that the consumption of fruits and vegetables may be associated with a lower incidence of cancer. The fruit of the Olea europaea L. and olive oil contain hundreds of phytochemicals and its extracts have recently been shown to exhibit antioxidant properties, due to the action of oleuropein. In view of these considerations, in this study, we investigated the effects of oleuropein on LNCaP and DU145 prostate cancer cell lines and on BPH-1 non-malignant cells. Oleuropein reduces cell viability and induces thiol group modifications, γ-glutamylcysteine synthetase, reactive oxygen species, pAkt and heme oxygenase-1. Exposing cell cultures to oleuropein induces an antioxidant effect on BPH-1 cells and a pro-oxidant effect on cancer cells. Our results confirm the beneficial properties of olive oil and oleuropein, suggesting its possible use as an adjuvant agent in the treatment of prostatitis, in order to prevent the transformation of hypertrophic to cancerous cells.

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Copy and paste a formatted citation
Spandidos Publications style
Acquaviva R, Di Giacomo C, Sorrenti V, Galvano F, Santangelo R, Cardile V, Gangia S, D'Orazio N, Abraham NG, Vanella L, Vanella L, et al: Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol 41: 31-38, 2012.
APA
Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V. ... Vanella, L. (2012). Antiproliferative effect of oleuropein in prostate cell lines. International Journal of Oncology, 41, 31-38. https://doi.org/10.3892/ijo.2012.1428
MLA
Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V., Gangia, S., D'Orazio, N., Abraham, N. G., Vanella, L."Antiproliferative effect of oleuropein in prostate cell lines". International Journal of Oncology 41.1 (2012): 31-38.
Chicago
Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V., Gangia, S., D'Orazio, N., Abraham, N. G., Vanella, L."Antiproliferative effect of oleuropein in prostate cell lines". International Journal of Oncology 41, no. 1 (2012): 31-38. https://doi.org/10.3892/ijo.2012.1428
Copy and paste a formatted citation
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Spandidos Publications style
Acquaviva R, Di Giacomo C, Sorrenti V, Galvano F, Santangelo R, Cardile V, Gangia S, D'Orazio N, Abraham NG, Vanella L, Vanella L, et al: Antiproliferative effect of oleuropein in prostate cell lines. Int J Oncol 41: 31-38, 2012.
APA
Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V. ... Vanella, L. (2012). Antiproliferative effect of oleuropein in prostate cell lines. International Journal of Oncology, 41, 31-38. https://doi.org/10.3892/ijo.2012.1428
MLA
Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V., Gangia, S., D'Orazio, N., Abraham, N. G., Vanella, L."Antiproliferative effect of oleuropein in prostate cell lines". International Journal of Oncology 41.1 (2012): 31-38.
Chicago
Acquaviva, R., Di Giacomo, C., Sorrenti, V., Galvano, F., Santangelo, R., Cardile, V., Gangia, S., D'Orazio, N., Abraham, N. G., Vanella, L."Antiproliferative effect of oleuropein in prostate cell lines". International Journal of Oncology 41, no. 1 (2012): 31-38. https://doi.org/10.3892/ijo.2012.1428
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