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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2012 Volume 41 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2012 Volume 41 Issue 4

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Article

A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis

  • Authors:
    • Ying-Wooi Wan
    • Rebecca A. Raese
    • James E. Fortney
    • Changchang Xiao
    • Dajie Luo
    • John Cavendish
    • Laura F. Gibson
    • Vincent Castranova
    • Yong Qian
    • Nancy Lan Guo

  • View Affiliations / Copyright

    Affiliations: Mary Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
  • Pages: 1387-1396
    |
    Published online on: July 16, 2012
       https://doi.org/10.3892/ijo.2012.1556
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Abstract

Smoking is responsible for 90% of lung cancer cases. There is currently no clinically available gene test for early detection of lung cancer in smokers, or an effective patient selection strategy for adjuvant chemotherapy in lung cancer treatment. In this study, concurrent coexpression with multiple signaling pathways was modeled among a set of genes associated with smoking and lung cancer survival. This approach identified and validated a 7-gene signature for lung cancer diagnosis and prognosis in smokers using patient transcriptional profiles (n=847). The smoking-associated gene coexpression networks in lung adenocarcinoma tumors (n=442) were highly significant in terms of biological relevance (network precision = 0.91, FDR<0.01) when evaluated with numerous databases containing multi-level molecular associations. The gene coexpression network in smoking lung adenocarcinoma patients was confirmed in qRT-PCR assays of the identified biomarkers and involved signaling pathway genes in human lung adenocarcinoma cells (H23) treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Furthermore, the western blotting results of p53, phospho‑p53, Rb and EGFR in NNK-treated H23 and transformed normal human lung epithelial cells (BEAS-2B) support their functional involvement in smoking-induced lung cancer carcinogenesis and progression.

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Copy and paste a formatted citation
Spandidos Publications style
Wan Y, Raese RA, Fortney JE, Xiao C, Luo D, Cavendish J, Gibson LF, Castranova V, Qian Y, Guo NL, Guo NL, et al: A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis. Int J Oncol 41: 1387-1396, 2012.
APA
Wan, Y., Raese, R.A., Fortney, J.E., Xiao, C., Luo, D., Cavendish, J. ... Guo, N.L. (2012). A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis. International Journal of Oncology, 41, 1387-1396. https://doi.org/10.3892/ijo.2012.1556
MLA
Wan, Y., Raese, R. A., Fortney, J. E., Xiao, C., Luo, D., Cavendish, J., Gibson, L. F., Castranova, V., Qian, Y., Guo, N. L."A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis". International Journal of Oncology 41.4 (2012): 1387-1396.
Chicago
Wan, Y., Raese, R. A., Fortney, J. E., Xiao, C., Luo, D., Cavendish, J., Gibson, L. F., Castranova, V., Qian, Y., Guo, N. L."A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis". International Journal of Oncology 41, no. 4 (2012): 1387-1396. https://doi.org/10.3892/ijo.2012.1556
Copy and paste a formatted citation
x
Spandidos Publications style
Wan Y, Raese RA, Fortney JE, Xiao C, Luo D, Cavendish J, Gibson LF, Castranova V, Qian Y, Guo NL, Guo NL, et al: A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis. Int J Oncol 41: 1387-1396, 2012.
APA
Wan, Y., Raese, R.A., Fortney, J.E., Xiao, C., Luo, D., Cavendish, J. ... Guo, N.L. (2012). A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis. International Journal of Oncology, 41, 1387-1396. https://doi.org/10.3892/ijo.2012.1556
MLA
Wan, Y., Raese, R. A., Fortney, J. E., Xiao, C., Luo, D., Cavendish, J., Gibson, L. F., Castranova, V., Qian, Y., Guo, N. L."A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis". International Journal of Oncology 41.4 (2012): 1387-1396.
Chicago
Wan, Y., Raese, R. A., Fortney, J. E., Xiao, C., Luo, D., Cavendish, J., Gibson, L. F., Castranova, V., Qian, Y., Guo, N. L."A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis". International Journal of Oncology 41, no. 4 (2012): 1387-1396. https://doi.org/10.3892/ijo.2012.1556
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