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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2013 Volume 42 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line

  • Authors:
    • Takuya Wakasaya
    • Hironori Yoshino
    • Yukako Fukushi
    • Atsushi Yoshizawa
    • Ikuo Kashiwakura
  • View Affiliations / Copyright

    Affiliations: Department of Radiological Life Sciences, Division of Medical Life Sciences, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan, Department of Frontier Materials Chemistry, Graduate School of Science and Technology, Hirosaki University, Hirosaki 036-8561, Japan
  • Pages: 1205-1211
    |
    Published online on: February 1, 2013
       https://doi.org/10.3892/ijo.2013.1804
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Abstract

Liquid crystals are the state of matter existing between liquid and crystalline phases, and recently there has been increasing interest in their biological effects. Following our recently reported work, we investigated the cell suppressive effects of liquid crystal-related compounds (LCRCs), which are precursors of liquid crystals, in the human non-small lung cancer cell line A549. We found that 2-(4-butoxyphenyl)-5-(4-hydroxyphenyl)pyrimidine (LCRC-1) dramatically suppressed cell growth. Treatment with 12 µM LCRC-1 for 12 h induced cell cycle arrest at the G2/M phase. Furthermore, LCRC-1 increased the sub-G1 fraction and Annexin V-positive cells and activated caspase-3 in A549 cells, which showed that it can induce apoptosis in these cells. Furthermore, because the induction of apoptosis by LCRC-1 was partly inhibited by treatment with pan-caspase inhibitor, it appeared that LCRC-1 induced apoptosis by a caspase-dependent pathway. The ability of LCRC-1 to cause DNA damage was assessed, but LCRC-1 did not induce expression of γ-H2AX, which is a marker of DNA damage. Treatment with LCRC-1 did not inhibit the proliferation of WI-38 normal fibroblast cells, which makes the tumor-specific suppressive effect of LCRC-1 attractive for its application as a new antitumor drug.
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Copy and paste a formatted citation
Spandidos Publications style
Wakasaya T, Yoshino H, Fukushi Y, Yoshizawa A and Kashiwakura I: A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line. Int J Oncol 42: 1205-1211, 2013.
APA
Wakasaya, T., Yoshino, H., Fukushi, Y., Yoshizawa, A., & Kashiwakura, I. (2013). A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line. International Journal of Oncology, 42, 1205-1211. https://doi.org/10.3892/ijo.2013.1804
MLA
Wakasaya, T., Yoshino, H., Fukushi, Y., Yoshizawa, A., Kashiwakura, I."A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line". International Journal of Oncology 42.4 (2013): 1205-1211.
Chicago
Wakasaya, T., Yoshino, H., Fukushi, Y., Yoshizawa, A., Kashiwakura, I."A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line". International Journal of Oncology 42, no. 4 (2013): 1205-1211. https://doi.org/10.3892/ijo.2013.1804
Copy and paste a formatted citation
x
Spandidos Publications style
Wakasaya T, Yoshino H, Fukushi Y, Yoshizawa A and Kashiwakura I: A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line. Int J Oncol 42: 1205-1211, 2013.
APA
Wakasaya, T., Yoshino, H., Fukushi, Y., Yoshizawa, A., & Kashiwakura, I. (2013). A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line. International Journal of Oncology, 42, 1205-1211. https://doi.org/10.3892/ijo.2013.1804
MLA
Wakasaya, T., Yoshino, H., Fukushi, Y., Yoshizawa, A., Kashiwakura, I."A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line". International Journal of Oncology 42.4 (2013): 1205-1211.
Chicago
Wakasaya, T., Yoshino, H., Fukushi, Y., Yoshizawa, A., Kashiwakura, I."A liquid crystal-related compound induces cell cycle arrest at the G2/M phase and apoptosis in the A549 human non-small cell lung cancer cell line". International Journal of Oncology 42, no. 4 (2013): 1205-1211. https://doi.org/10.3892/ijo.2013.1804
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