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Article

MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling

  • Authors:
    • Dilip Rajasekhar Maddirela
    • Divya Kesanakurti
    • Meena Gujrati
    • Jasti S. Rao
  • View Affiliations / Copyright

    Affiliations: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA, Department of Pathology, University of Illinois College of Medicine at Peoria, Peoria, IL 61605, USA
  • Pages: 1279-1288
    |
    Published online on: February 4, 2013
       https://doi.org/10.3892/ijo.2013.1806
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Abstract

The majority of glioblastoma multiforme (GBM) tumors recur after radiation (IR) treatment due to increased angiogenesis and IR-induced signaling events in endothelial cells (ECs) that are involved in tumor neovascularization; however, these signaling events have yet to be well characterized. In the present study, we observed that IR (8 Gy) significantly elevated MMP-2 expression and gelatinolytic activity in 4910 and 5310 human GBM xenograft cells. In addition, ECs treated with tumor-conditioned media (CM) obtained from IR-treated 4910 and 5310 cells showed increased microtubule formation. In view of this finding, we investigated the possible anti-angiogenic effects of MMP-2 downregulation using siRNA (pM.si) in IR-treated cells. We also determined the effect of CM obtained from mock, pSV (scrambled vector) and pMMP-2.si on endothelial cell growth and vessel formation. pM.si-CM-treated ECs showed inhibited IR-CM-induced SDF-1, CXCR4, phospho-PI3K and phospho-AKT and αvβ3 expression levels. In vitro angiogenesis assays also showed that the pM.si+IR decreased IR-induced vessel formation in ECs. Immunofluorescence and immunoprecipitation experiments indicated the abrogation of αvβ3-SDF-1 interaction in pM.si-CM-treated ECs when compared to mock or pSV treatments. External supplementation of either rhMMP-2 or rhSDF-1 counteracted and noticeably reversed pM.si-inhibited SDF-1, CXCR4, phospho-PI3K and phospho-AKT expression levels and angiogenesis, thereby confirming the role of MMP-2 in the regulation of αvβ3-mediated SDF-1/CXCR4 signaling. In addition to the in vitro results, the in vivo mouse dorsal air sac model also showed reduced angiogenesis after injection of pM.si alone or in combination with IR-treated xenograft cells. In contrast, injection of mock or pSV-treated cells resulted in robust formation of characteristic neovascularization. Collectively, our data demonstrate the role of MMP-2 in the regulation of SDF-1/CXCR4 signaling-mediated angiogenesis in ECs and show the anti-angiogenic efficacy of combining MMP-2 downregulation and IR when treating patients with GBM in the future.
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1 

Ribatti D and Djonov V: Angiogenesis in development and cancer today. Int J Dev Biol. 55:343–344. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Kargiotis O, Geka A, Rao JS and Kyritsis AP: Effects of irradiation on tumor cell survival, invasion and angiogenesis. J Neurooncol. 100:323–338. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Wachsberger P, Burd R and Dicker AP: Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin Cancer Res. 9:1957–1971. 2003.

4 

Chetty C, Lakka SS, Bhoopathi P, Kunigal S, Geiss R and Rao JS: Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer. Cancer Res. 68:4736–4745. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Badiga AV, Chetty C, Kesanakurti D, et al: MMP-2 siRNA inhibits radiation-enhanced invasiveness in glioma cells. PLoS One. 6:e206142011. View Article : Google Scholar : PubMed/NCBI

6 

Kesanakurti D, Chetty C, Bhoopathi P, Lakka SS, Gorantla B, Tsung AJ and Rao JS: Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma. PLoS One. 6:e193412011.

7 

Robinson SD and Hodivala-Dilke KM: The role of beta3-integrins in tumor angiogenesis: context is everything. Curr Opin Cell Biol. 23:630–637. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM and Cheresh DA: Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol. 155:459–470. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G and Cheresh DA: Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79:1157–1164. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Barbero S, Bonavia R, Bajetto A, et al: Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res. 63:1969–1974. 2003.

11 

Shen XY, Wang SH, Liang ML, Wang HB, Xiao L and Wang ZH: The role and mechanism of CXCR4 and its ligand SDF-1 in the development of cervical cancer metastasis. Ai Zheng. 27:1044–1049. 2008.(In Chinese).

12 

Zou YR, Kottmann AH, Kuroda M, Taniuchi I and Littman DR: Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 393:595–599. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Kucia M, Jankowski K, Reca R, et al: CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol. 35:233–245. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Giannini C, Sarkaria JN, Saito A, et al: Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme. Neurooncology. 7:164–176. 2005.PubMed/NCBI

15 

Kesanakurti D, Chetty C, Dinh DH, Gujrati M and Rao JS: Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with alpha5beta1 integrin in glioma. Oncogene. 32:327–340. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Kesanakurti D, Chetty C, Maddirella DR, Gujrati M and Rao JS: Essential role of cooperative NF-κB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma. Oncogene. Nov 26–2012.(Epub ahead of print). View Article : Google Scholar

17 

Chetty C, Lakka SS, Bhoopathi P and Rao JS: MMP-2 alters VEGF expression via aVB3 integrin-mediated PIK/AKT signaling in A549 lung cancer cells. Int J Cancer. 127:1081–1095. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Kesanakurti D, Chetty C, Maddirela DR, Gujrati M and Rao JS: Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis-resistance, migration and invasion in glioma. Cell Death Dis. (In Press).

19 

Salvucci O, Yao L, Villalba S, Sajewicz A, Pittaluga S and Tosato G: Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood. 99:2703–2711. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Bhoopathi P, Chetty C, Gogineni VR, Gujrati M, Dinh DH, Rao JS and Lakka SS: MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors. Gene Ther. 18:692–701. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Trisciuoglio D, Iervolino A, Zupi G and Del Bufalo D: Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells. Mol Biol Cell. 16:4153–4162. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Berglin L, Sarman S, van der Plloeg I, et al: Reduced choroidal neovascular membrane formation in matrix metallo proteinase-2-deficient mice. Invest Ophthalmol Vis Sci. 44:403–408. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Abdollahi A, Griggs DW, Zieher H, et al: Inhibition of alpha(v) beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy. Clin Cancer Res. 11:6270–6279. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Prise KM, Schettino G, Folkard M and Held KD: New insights on cell death from radiation exposure. Lancet Oncol. 6:520–528. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Albert JM, Cao C, Geng L, Leavitt L, Hallahan DE and Lu B: Integrin alpha v beta 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models. Int J Radiat Oncol Biol Phys. 65:1536–1543. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Monferran S, Skuli N, Delmas C, Favre G, Bonnet J, Cohen-Jonathan-Moyal E and Toulas C: Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB. Int J Cancer. 123:357–364. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Monnier Y, Farmer P, Bieler G, et al: CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 68:7323–7331. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Rao JS: Molecular mechanisms of glioma invasiveness: the role of proteases. Nat Rev Cancer. 3:489–501. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Qian LW, Mizumoto K, Urashima T, et al: Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023. Clin Cancer Res. 8:1223–1227. 2002.

30 

Trog D, Yeghiazaryan K, Fountoulakis M, et al: Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells. Eur J Pharmacol. 542:8–15. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Speake WJ, Dean RA, Kumar A, Morris TM, Scholefield JH and Watson SA: Radiation induced MMP expression from rectal cancer is short lived but contributes to in vitro invasion. Eur J Surg Oncol. 31:869–874. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Tseng D, Vasquez-Medrano DA and Brown JM: Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas. Br J Cancer. 104:1805–1809. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:353–364. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Liekens S, De Clercq E and Neyts J: Angiogenesis: regulators and clinical applications. Biochem Pharmacol. 61:253–270. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Balkwill F: The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol. 14:171–179. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Chang CC, Lerman OZ, Thanik VD, et al: Dose-dependent effect of radiation on angiogenic and angiostatic CXC chemokine expression in human endothelial cells. Cytokine. 48:295–302. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Heissig B, Rafii S, Akiyama H, et al: Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med. 202:739–750. 2005. View Article : Google Scholar

38 

Moeller BJ, Cao Y, Li CY and Dewhirst MW: Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals and stress granules. Cancer Cell. 5:429–441. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Garcia-Moruja C, Alonso-Lobo JM, Rueda P, et al: Functional characterization of SDF-1 proximal promoter. J Mol Biol. 348:43–62. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Fujimori A, Okayasu R, Ishihara H, et al: Extremely low dose ionizing radiation up-regulates CXC chemokines in normal human fibroblasts. Cancer Res. 65:10159–10163. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Brooks PC, Clark RA and Cheresh DA: Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science. 264:569–571. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Brooks PC: Role of integrins in angiogenesis. Eur J Cancer. 32A:2423–2429. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Gladson CL: Expression of integrin alpha v beta 3 in small blood vessels of glioblastoma tumors. J Neuropathol Exp Neurol. 55:1143–1149. 1996. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Maddirela DR, Kesanakurti D, Gujrati M and Rao JS: MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling. Int J Oncol 42: 1279-1288, 2013.
APA
Maddirela, D.R., Kesanakurti, D., Gujrati, M., & Rao, J.S. (2013). MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling. International Journal of Oncology, 42, 1279-1288. https://doi.org/10.3892/ijo.2013.1806
MLA
Maddirela, D. R., Kesanakurti, D., Gujrati, M., Rao, J. S."MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling". International Journal of Oncology 42.4 (2013): 1279-1288.
Chicago
Maddirela, D. R., Kesanakurti, D., Gujrati, M., Rao, J. S."MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling". International Journal of Oncology 42, no. 4 (2013): 1279-1288. https://doi.org/10.3892/ijo.2013.1806
Copy and paste a formatted citation
x
Spandidos Publications style
Maddirela DR, Kesanakurti D, Gujrati M and Rao JS: MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling. Int J Oncol 42: 1279-1288, 2013.
APA
Maddirela, D.R., Kesanakurti, D., Gujrati, M., & Rao, J.S. (2013). MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling. International Journal of Oncology, 42, 1279-1288. https://doi.org/10.3892/ijo.2013.1806
MLA
Maddirela, D. R., Kesanakurti, D., Gujrati, M., Rao, J. S."MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling". International Journal of Oncology 42.4 (2013): 1279-1288.
Chicago
Maddirela, D. R., Kesanakurti, D., Gujrati, M., Rao, J. S."MMP-2 suppression abrogates irradiation-induced microtubule formation in endothelial cells by inhibiting αvβ3-mediated SDF-1/CXCR4 signaling". International Journal of Oncology 42, no. 4 (2013): 1279-1288. https://doi.org/10.3892/ijo.2013.1806
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