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Article

The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy

  • Authors:
    • So Y. Kim
    • Sujin Kang
    • Jae J. Song
    • Joo-Hang Kim
  • View Affiliations / Copyright

    Affiliations: Institute for Cancer Research, College of Medicine, Yonsei University, Seoul, Republic of Korea, Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea
  • Pages: 1337-1348
    |
    Published online on: February 7, 2013
       https://doi.org/10.3892/ijo.2013.1812
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Abstract

To overcome the poor tumor transduction efficiency of adenovirus serotype 5 (Ad5) observed in several types of cancer, the fiber region of Ad5, apart from its tail, was replaced by adenovirus serotype 35 (Ad35). The chimeric Ad5̸F35 adenoviral vector did not exhibit any significant enhancement of transduction efficiency. CD46, a receptor for Ad35, was expressed in relatively small amounts in most of the cancer cells examined. Therefore, we investigated the pivotal factor(s) that render cancer cells susceptible to transduction. We discovered that the tumor transduction efficiency of Ad5/F35 was enhanced in the presence of rapamycin, an autophagy inducer, in some cancer cells. Analysis of survival potential and cell proliferation rates revealed that Ad5/F35 exerted a more pronounced oncolytic effect in cancer cells with higher survival potential in the presence of rapamycin.
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Copy and paste a formatted citation
Spandidos Publications style
Kim SY, Kang S, Song JJ and Kim J: The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy. Int J Oncol 42: 1337-1348, 2013.
APA
Kim, S.Y., Kang, S., Song, J.J., & Kim, J. (2013). The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy. International Journal of Oncology, 42, 1337-1348. https://doi.org/10.3892/ijo.2013.1812
MLA
Kim, S. Y., Kang, S., Song, J. J., Kim, J."The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy". International Journal of Oncology 42.4 (2013): 1337-1348.
Chicago
Kim, S. Y., Kang, S., Song, J. J., Kim, J."The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy". International Journal of Oncology 42, no. 4 (2013): 1337-1348. https://doi.org/10.3892/ijo.2013.1812
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SY, Kang S, Song JJ and Kim J: The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy. Int J Oncol 42: 1337-1348, 2013.
APA
Kim, S.Y., Kang, S., Song, J.J., & Kim, J. (2013). The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy. International Journal of Oncology, 42, 1337-1348. https://doi.org/10.3892/ijo.2013.1812
MLA
Kim, S. Y., Kang, S., Song, J. J., Kim, J."The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy". International Journal of Oncology 42.4 (2013): 1337-1348.
Chicago
Kim, S. Y., Kang, S., Song, J. J., Kim, J."The effectiveness of the oncolytic activity induced by Ad5/F35 adenoviral vector is dependent on the cumulative cellular conditions of survival and autophagy". International Journal of Oncology 42, no. 4 (2013): 1337-1348. https://doi.org/10.3892/ijo.2013.1812
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