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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2013 Volume 42 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer

  • Authors:
    • Mei Sun
    • Rui Jiang
    • Guan Wang
    • Chao Zhang
    • Jindong Li
    • Chengyan Jin
    • Xingyi Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Second Hospital of Jilin University, Changchun 130041, P.R. China, Department of Orthopedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, P.R. China, Department of Cardiac Medicine, The Second Hospital of Jilin University, Changchun 130041, P.R. China, Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, P.R. China, Department of Thoracic Surgery, The Second Hospital of Jilin University, Changchun 130041, P.R. China
  • Pages: 1376-1382
    |
    Published online on: February 8, 2013
       https://doi.org/10.3892/ijo.2013.1813
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Abstract

Cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), a growth suppressor that negatively regulates CDK2 activity, has been implicated in various types of cancer; yet its role in lung cancer remains unclear. In the present study, a lentivirus-based system was used to specifically downregulate or upregulate CDK2AP1 expression. A549 lung cancer cells were treated with RNAi (RNA interference) or lentiviral vectors for overexpression. Ectopic overexpression of CDK2AP1 in A549 cells in vitro greatly impaired their proliferation and colony-forming ability and enhanced their chemosensitivity to cisplatin and paclitaxel and caused cell cycle arrest at G1/S transition accompanied by the reduction of expression of CDK4 and CDK7. Injection of the ectopically CDK2AP1-overexpressing A549 cells into nude mice resulted in growth arrest of solid lung cancer tumors in vivo. Knockdown of CDK2AP1 in A549 cells, however, gave rise to the opposite effects including promoting cell proliferation/growth, cell cycling in vitro and enhancing tumorigenesis in vivo. These results suggest that CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells and also has significant effects on the chemosensitivity of pulmonary malignancies to chemotherapeutics. Hence, this study extends our knowledge on the relationship between CDK2AP1 and oncogenesis of lung cancer, indicating that CDK2AP1 may serve as a new molecular target for future lung cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Sun M, Jiang R, Wang G, Zhang C, Li J, Jin C and Zhang X: Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer. Int J Oncol 42: 1376-1382, 2013.
APA
Sun, M., Jiang, R., Wang, G., Zhang, C., Li, J., Jin, C., & Zhang, X. (2013). Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer. International Journal of Oncology, 42, 1376-1382. https://doi.org/10.3892/ijo.2013.1813
MLA
Sun, M., Jiang, R., Wang, G., Zhang, C., Li, J., Jin, C., Zhang, X."Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer". International Journal of Oncology 42.4 (2013): 1376-1382.
Chicago
Sun, M., Jiang, R., Wang, G., Zhang, C., Li, J., Jin, C., Zhang, X."Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer". International Journal of Oncology 42, no. 4 (2013): 1376-1382. https://doi.org/10.3892/ijo.2013.1813
Copy and paste a formatted citation
x
Spandidos Publications style
Sun M, Jiang R, Wang G, Zhang C, Li J, Jin C and Zhang X: Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer. Int J Oncol 42: 1376-1382, 2013.
APA
Sun, M., Jiang, R., Wang, G., Zhang, C., Li, J., Jin, C., & Zhang, X. (2013). Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer. International Journal of Oncology, 42, 1376-1382. https://doi.org/10.3892/ijo.2013.1813
MLA
Sun, M., Jiang, R., Wang, G., Zhang, C., Li, J., Jin, C., Zhang, X."Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer". International Journal of Oncology 42.4 (2013): 1376-1382.
Chicago
Sun, M., Jiang, R., Wang, G., Zhang, C., Li, J., Jin, C., Zhang, X."Cyclin-dependent kinase 2-associated protein 1 suppresses growth and tumorigenesis of lung cancer". International Journal of Oncology 42, no. 4 (2013): 1376-1382. https://doi.org/10.3892/ijo.2013.1813
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