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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2013 Volume 42 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer

  • Authors:
    • Géraldine Philippin-Lauridant
    • Marie-Christine Baranzelli
    • Chantal Samson
    • Charles Fournier
    • Sébastien Pinte
    • Virginie Mattot
    • Jacques Bonneterre
    • Fabrice Soncin
  • View Affiliations / Copyright

    Affiliations: CNRS UMR8161, National Center for Scientific Research, Institute of Biology of Lille, 59021 Lille, France, Department of General Oncology, Centre Oscar Lambret, 59020 Lille, France
  • Pages: 1367-1375
    |
    Published online on: February 8, 2013
       https://doi.org/10.3892/ijo.2013.1820
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Abstract

Egfl7 (VE-statin) is specifically expressed by endothelial cells of normal tissues but its expression is deregulated in human cancers. Analysis of expression of Egfl7 protein and transcripts in 211 human breast cancer samples shows that Egfl7 is strongly expressed by breast tumor cells. Egfl7 expression is significantly higher in invasive ductal than in invasive lobular carcinoma. Expression of Egfl7 transcripts is also higher in lower SBR grade lesions and in lesions which are not associated with lymph node invasion. Within the invasive ductal carcinoma sub-population, expression of Egfl7 transcripts is correlated with the SBR score and with the ER+ status. High transcript and Egfl7 protein levels significantly correlate with the absence of axillary lymph node invasion. In lymph nodes, the levels of Egfl7 are correlated with the histological type of the primary lesions; they are higher in ductal than in lobular carcinoma. Egfl7 expression is thus associated with better prognosis factors and with the absence of lymph node invasion in human breast cancer lesions.
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Copy and paste a formatted citation
Spandidos Publications style
Philippin-Lauridant G, Baranzelli M, Samson C, Fournier C, Pinte S, Mattot V, Bonneterre J and Soncin F: Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer. Int J Oncol 42: 1367-1375, 2013.
APA
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V. ... Soncin, F. (2013). Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer. International Journal of Oncology, 42, 1367-1375. https://doi.org/10.3892/ijo.2013.1820
MLA
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V., Bonneterre, J., Soncin, F."Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer". International Journal of Oncology 42.4 (2013): 1367-1375.
Chicago
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V., Bonneterre, J., Soncin, F."Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer". International Journal of Oncology 42, no. 4 (2013): 1367-1375. https://doi.org/10.3892/ijo.2013.1820
Copy and paste a formatted citation
x
Spandidos Publications style
Philippin-Lauridant G, Baranzelli M, Samson C, Fournier C, Pinte S, Mattot V, Bonneterre J and Soncin F: Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer. Int J Oncol 42: 1367-1375, 2013.
APA
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V. ... Soncin, F. (2013). Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer. International Journal of Oncology, 42, 1367-1375. https://doi.org/10.3892/ijo.2013.1820
MLA
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V., Bonneterre, J., Soncin, F."Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer". International Journal of Oncology 42.4 (2013): 1367-1375.
Chicago
Philippin-Lauridant, G., Baranzelli, M., Samson, C., Fournier, C., Pinte, S., Mattot, V., Bonneterre, J., Soncin, F."Expression of Egfl7 correlates with low-grade invasive lesions in human breast cancer". International Journal of Oncology 42, no. 4 (2013): 1367-1375. https://doi.org/10.3892/ijo.2013.1820
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