|
1.
|
Chen BJ: Triptolide, a novel
immunosuppressive and anti-inflammatory agent purified from a
Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphoma.
42:253–265. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
2.
|
Lue Y, Sinha Hikim AP, Wang C, et al:
Triptolide: a potential male contraceptive. J Androl. 19:479–486.
1998.PubMed/NCBI
|
|
3.
|
Qiu D, Zhao G, Aoki Y, et al:
Immunosuppressant PG490 (trip-tolide) inhibits T-cell interleukin-2
expression at the level of purine-box/nuclear factor of activated
T-cells and NF-kappaB transcriptional activation. J Biol Chem.
274:13443–13450. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Fidler JM, Li K, Chung C, et al: PG490-88,
a derivative of triptolide, causes tumor regression and sensitizes
tumors to chemotherapy. Mol Cancer Ther. 2:855–862. 2003.PubMed/NCBI
|
|
5.
|
Jiang XH, Wong BC, Lin MC, et al:
Functional p53 is required for triptolide-induced apoptosis and
AP-1 and nuclear factor-kappaB activation in gastric cancer cells.
Oncogene. 20:8009–8018. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
6.
|
Lee KY, Chang W, Qiu D, et al: PG490
(triptolide) cooperates with tumor necrosis factor-alpha to induce
apoptosis in tumor cells. J Biol Chem. 274:13451–13455. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
7.
|
Chang WT, Kang JJ, Lee KY, et al:
Triptolide and chemotherapy cooperate in tumor cell apoptosis. A
role for the p53 pathway. J Biol Chem. 276:2221–2227. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Matsui Y, Watanabe J, Ikegawa M, et al:
Cancer-specific enhancement of cisplatin-induced cytotoxicity with
triptolide through an interaction of inactivated glycogen synthase
kinase-3beta with p53. Oncogene. 27:4603–4614. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Miyata Y, Sato T and Ito A: Triptolide, a
diterpenoid triepoxide, induces antitumor proliferation via
activation of c-Jun NH2-terminal kinase 1 by decreasing
phosphatidylinositol 3-kinase activity in human tumor cells.
Biochem Biophys Res Commun. 336:1081–1086. 2005. View Article : Google Scholar
|
|
10.
|
Phillips PA, Dudeja V, McCarroll JA, et
al: Triptolide induces pancreatic cancer cell death via inhibition
of heat shock protein 70. Cancer Res. 67:9407–9416. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
11.
|
Carter BZ, Mak DH, Schober WD, et al:
Triptolide induces caspase-dependent cell death mediated via the
mitochondrial pathway in leukemic cells. Blood. 108:630–637. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
12.
|
Wang Y, Lu JJ, He L, et al: Triptolide
(TPL) inhibits global transcription by inducing
proteasome-dependent degradation of RNA polymerase II (Pol II).
PLoS One. 6:e239932011. View Article : Google Scholar : PubMed/NCBI
|
|
13.
|
Huang W, He T, Chai C, et al: Triptolide
inhibits the proliferation of prostate cancer cells and
down-regulates SUMO-specific protease 1 expression. PLoS One.
7:e376932012. View Article : Google Scholar : PubMed/NCBI
|
|
14.
|
Frese S, Pirnia F, Miescher D, et al:
PG490-mediated sensitization of lung cancer cells to
Apo2L/TRAIL-induced apoptosis requires activation of ERK2.
Oncogene. 22:5427–5435. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
Bacus SS, Gudkov AV, Lowe M, et al:
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and
p38) and is independent of p53. Oncogene. 20:147–155. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
16.
|
Tang D, Wu D, Hirao A, et al: ERK
activation mediates cell cycle arrest and apoptosis after DNA
damage independently of p53. J Biol Chem. 277:12710–12717. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
17.
|
Arai K, Lee SR, van Leyen K, et al:
Involvement of ERK MAP kinase in endoplasmic reticulum stress in
SH-SY5Y human neuroblastoma cells. J Neurochem. 89:232–239. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
18.
|
Hu P, Han Z, Couvillon AD, et al: Critical
role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting
endoplasmic reticulum stress-induced cell death. J Biol Chem.
279:49420–49429. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
19.
|
Wan CK, Wang C, Cheung HY, et al:
Triptolide induces Bcl-2 cleavage and mitochondria dependent
apoptosis in p53-deficient HL-60 cells. Cancer Lett. 241:31–41.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
20.
|
Bao X, Cui J, Wu Y, et al: The roles of
endogenous reactive oxygen species and nitric oxide in
triptolide-induced apoptotic cell death in macrophages. J Mol Med
(Berl). 85:85–98. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
21.
|
Xu B, Guo X, Mathew S, et al: Triptolide
simultaneously induces reactive oxygen species, inhibits NF-kappaB
activity and sensitizes 5-fluorouracil in colorectal cancer cell
lines. Cancer Lett. 291:200–208. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
22.
|
Dong J, Ramachandiran S, Tikoo K, et al:
EGFR-independent activation of p38 MAPK and EGFR-dependent
activation of ERK1/2 are required for ROS-induced renal cell death.
Am J Physiol Renal Physiol. 287:F1049–F1058. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
23.
|
Ramachandiran S, Huang Q, Dong J, et al:
Mitogen-activated protein kinases contribute to reactive oxygen
species-induced cell death in renal proximal tubule epithelial
cells. Chem Res Toxicol. 15:1635–1642. 2002. View Article : Google Scholar
|
|
24.
|
Wang X, Martindale JL and Holbrook NJ:
Requirement for ERK activation in cisplatin-induced apoptosis. J
Biol Chem. 275:39435–39443. 2000. View Article : Google Scholar
|
|
25.
|
Zhuang S, Yan Y, Daubert RA, et al: ERK
promotes hydrogen peroxide-induced apoptosis through caspase-3
activation and inhibition of Akt in renal epithelial cells. Am J
Physiol Renal Physiol. 292:F440–F447. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
26.
|
Yao J, Jiang Z, Duan W, et al: Involvement
of mitochondrial pathway in triptolide-induced cytotoxicity in
human normal liver L-02 cells. Biol Pharm Bull. 31:592–597. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Kim YK, Kim HJ, Kwon CH, et al: Role of
ERK activation in cisplatin-induced apoptosis in OK renal
epithelial cells. J Appl Toxicol. 25:374–382. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28.
|
Hsieh YH, Su IJ, Lei HY, et al:
Differential endoplasmic reticulum stress signaling pathways
mediated by iNOS. Biochem Biophys Res Commun. 359:643–648. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
29.
|
Malhotra JD and Kaufman RJ: Endoplasmic
reticulum stress and oxidative stress: a vicious cycle or a
double-edged sword? Antioxid Redox Signal. 9:2277–2293. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Kupchan SM and Schubert RM: Selective
alkylation: a biomimetic reaction of the antileukemic triptolides?
Science. 185:791–793. 1974. View Article : Google Scholar : PubMed/NCBI
|
|
31.
|
Liu Q: Triptolide and its expanding
multiple pharmacological functions. Int Immunopharmacol.
11:377–383. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
32.
|
Zhuang S and Schnellmann RG: A
death-promoting role for extracellular signal-regulated kinase. J
Pharmacol Exp Ther. 319:991–997. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Li CJ, Chu CY, Huang LH, et al:
Synergistic anticancer activity of triptolide combined with
cisplatin enhances apoptosis in gastric cancer in vitro and in
vivo. Cancer Lett. 319:203–213. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
34.
|
Urano F, Wang X, Bertolotti A, et al:
Coupling of stress in the ER to activation of JNK protein kinases
by transmembrane protein kinase IRE1. Science. 287:664–666. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Mhaidat NM, Thorne R, Zhang XD, et al:
Involvement of endoplasmic reticulum stress in Docetaxel-induced
JNK-dependent apoptosis of human melanoma. Apoptosis. 13:1505–1512.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
36.
|
Boucher MJ, Morisset J, Vachon PH, et al:
MEK/ERK signaling pathway regulates the expression of Bcl-2,
Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic
cancer cells. J Cell Biochem. 79:355–369. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
37.
|
Dai R, Chen R and Li H: Cross-talk between
PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum
stress-induced cell cycle progression and cell death in human
hepatocellular carcinoma cells. Int J Oncol. 34:1749–1757.
2009.
|
