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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2013 Volume 42 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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International Journal of Functional Nutrition

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Article

Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype

  • Authors:
    • Hongjun Wang
    • Yongzhi Wang
    • Chuanlu Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, P.R. China, Department of Neurosurgery, Tiantan Hospital, Capital Medical University, Beijing, P.R. China
  • Pages: 1716-1724
    |
    Published online on: March 5, 2013
       https://doi.org/10.3892/ijo.2013.1847
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Abstract

To explore the expression pattern, prognostic value and functional role of stromal periostin (POSTN) in glioma patients, POSTN expression was measured using the Agilent Whole Human Genome Oligo Microarray in 220 frozen glioma tissues. We analyzed POSTN expression in 71 independent validated glioma samples using immuno­histochemistry. The expression levels of POSTN were relative to glioma grade progression and inversely correlated with overall survival in high-grade glioma patients (anaplastic gliomas and glioblastomas). Gene ontology (GO) analysis performed using DAVID showed that the gene sets related to cell migration and proliferation were significantly enriched in the cases with POSTN overexpression. Functional analyses in LN229 and U87 cells revealed that POSTN was involved in cell invasion and proliferation. MMP-9 was an effector of POSTN signaling in glioma cells. The expression of stromal protein POSTN is relative to glioma grade progression and confers a poor prognosis via promoting cellular invasion and proliferation in high-grade glioma patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Wang Y and Jiang C: Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype. Int J Oncol 42: 1716-1724, 2013.
APA
Wang, H., Wang, Y., & Jiang, C. (2013). Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype. International Journal of Oncology, 42, 1716-1724. https://doi.org/10.3892/ijo.2013.1847
MLA
Wang, H., Wang, Y., Jiang, C."Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype". International Journal of Oncology 42.5 (2013): 1716-1724.
Chicago
Wang, H., Wang, Y., Jiang, C."Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype". International Journal of Oncology 42, no. 5 (2013): 1716-1724. https://doi.org/10.3892/ijo.2013.1847
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Wang Y and Jiang C: Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype. Int J Oncol 42: 1716-1724, 2013.
APA
Wang, H., Wang, Y., & Jiang, C. (2013). Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype. International Journal of Oncology, 42, 1716-1724. https://doi.org/10.3892/ijo.2013.1847
MLA
Wang, H., Wang, Y., Jiang, C."Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype". International Journal of Oncology 42.5 (2013): 1716-1724.
Chicago
Wang, H., Wang, Y., Jiang, C."Stromal protein periostin identified as a progression associated and prognostic biomarker in glioma via inducing an invasive and proliferative phenotype". International Journal of Oncology 42, no. 5 (2013): 1716-1724. https://doi.org/10.3892/ijo.2013.1847
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