Selenium-binding protein 1 may decrease gastric cellular proliferation and migration

  • Authors:
    • Chenjing Zhang
    • Wen Xu
    • Wensheng Pan
    • Nana Wang
    • Guogang Li
    • Xiaoyuan Fan
    • Xiang Xu
    • Shengrong Shen
    • Undurti N. Das
  • View Affiliations

  • Published online on: March 7, 2013     https://doi.org/10.3892/ijo.2013.1850
  • Pages: 1620-1629
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Abstract

It has been reported that suppression of selenium‑binding protein 1 (SBP1) occurs in many human malignancies which is considered to play an important role in cancer development and progression. Despite its importance in cancer, the function and factors that regulate its expression are not known. Using cell proliferation assays, immunochemical staining and immunoblotting and flow cytometry methods and in a xenograft model, we evaluated the role of SBP1 in proliferation, migration, senescence and chemoresistance of gastric cancer cells (SGC7901 and BGC823) to cisplatin. It was noted that diminished SBP1 expression increased gastric cancer cell proliferation and cell migration and decreased cisplatin-induced apoptosis while its overexpression produced the opposite effects. These results suggest that SBP1 plays a significant role in gastric cancer cell proliferation and modulates its response to anticancer drugs. These results suggest that SBP1 can serve as a potential target to suppress gastric cancer.
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May 2013
Volume 42 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang C, Xu W, Pan W, Wang N, Li G, Fan X, Xu X, Shen S and Das UN: Selenium-binding protein 1 may decrease gastric cellular proliferation and migration. Int J Oncol 42: 1620-1629, 2013
APA
Zhang, C., Xu, W., Pan, W., Wang, N., Li, G., Fan, X. ... Das, U.N. (2013). Selenium-binding protein 1 may decrease gastric cellular proliferation and migration. International Journal of Oncology, 42, 1620-1629. https://doi.org/10.3892/ijo.2013.1850
MLA
Zhang, C., Xu, W., Pan, W., Wang, N., Li, G., Fan, X., Xu, X., Shen, S., Das, U. N."Selenium-binding protein 1 may decrease gastric cellular proliferation and migration". International Journal of Oncology 42.5 (2013): 1620-1629.
Chicago
Zhang, C., Xu, W., Pan, W., Wang, N., Li, G., Fan, X., Xu, X., Shen, S., Das, U. N."Selenium-binding protein 1 may decrease gastric cellular proliferation and migration". International Journal of Oncology 42, no. 5 (2013): 1620-1629. https://doi.org/10.3892/ijo.2013.1850