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Prognostic value of CAPZA1 overexpression in gastric cancer

  • Authors:
    • Young-Joon Lee
    • Sang-Ho Jeong
    • Soon-Chan Hong
    • Bok-Im Cho
    • Woo-Song Ha
    • Soon-Tae Park
    • Sang-Kyung Choi
    • Eun-Jung Jung
    • Young-Tae Ju
    • Chi-Young Jeong
    • Jae Won Kim
    • Chang Won Lee
    • Jiyun Yoo
    • Gyung Hyuck Ko
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Postgraduate School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University, Jinju, Republic of Korea, Department of Microbiology, Research Institute of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju, Republic of Korea, Department of Pathology, Gyeongsang National University, Jinju, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
  • Pages: 1569-1577
    |
    Published online on: March 27, 2013
       https://doi.org/10.3892/ijo.2013.1867
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Abstract

F-actin capping protein α1 subunit (CAPZA1) was previously identified in a proteomic analysis of human gastric cancer clinical specimens and selected for further study. The association between CAPZA1 overexpression, detected by immunohistochemistry, and clinicopathological features including survival were evaluated. In vitro gain-of-function and loss-of-function approaches were utilized to assess the function of CPAZA1 in malignancy. Univariate analysis revealed that poorly differentiated disease, according to the World Health Organization (WHO) classification, advanced T stage, positive lymph nodes, high TNM stage, D2 lymph node dissection, adjuvant chemotherapy and CAPZA1 underexpression were significantly associated with cancer-related death (p<0.05); however, only high TNM stage remained significantly associated by multivariate analysis (p<0.01). CAPZA1 overexpression was associated with well differentiated histology, smaller tumor size, lower T stage, absence of lymph node metastasis, lower TNM stage, lower recurrence rate and longer survival time, compared to CAPZA1 underexpression. In vitro, forced expression of CAPZA1 caused a significant decrease in gastric cancer cell migration and invasion, whereas CAPZA1 depletion had the opposite effect. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion.
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1. 

Lee HJ, Yang HK and Ahn YO: Gastric cancer in Korea. Gastric Cancer. 5:177–182. 2002. View Article : Google Scholar

2. 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar

3. 

Sakuramoto S, Sasako M, Yamaguchi T, et al: Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 357:1810–1820. 2007. View Article : Google Scholar : PubMed/NCBI

4. 

Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 376:687–697. 2010. View Article : Google Scholar

5. 

Chen CD, Wang CS, Huang YH, et al: Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance. Proteomics. 7:155–167. 2007. View Article : Google Scholar : PubMed/NCBI

6. 

Cho HJ, Baek KE, Park SM, et al: RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer. Clin Cancer Res. 15:2612–2619. 2009. View Article : Google Scholar : PubMed/NCBI

7. 

Kim MA, Lee HS, Lee HE, Jeon YK, Yang HK and Kim WH: EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number. Histopathology. 52:738–746. 2008. View Article : Google Scholar : PubMed/NCBI

8. 

Lim BH, Cho BI, Kim YN, Kim JW, Park ST and Lee CW: Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification. Exp Mol Med. 38:455–465. 2006. View Article : Google Scholar : PubMed/NCBI

9. 

Waddle JA, Cooper JA and Waterston RH: The alpha and beta subunits of nematode actin capping protein function in yeast. Mol Biol Cell. 4:907–917. 1993. View Article : Google Scholar : PubMed/NCBI

10. 

Hopmann R, Cooper JA and Miller KG: Actin organization, bristle morphology, and viability are affected by actin capping protein mutations in Drosophila. J Cell Biol. 133:1293–1305. 1996. View Article : Google Scholar : PubMed/NCBI

11. 

Amatruda JF, Cannon JF, Tatchell K, Hug C and Cooper JA: Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature. 344:352–354. 1990. View Article : Google Scholar : PubMed/NCBI

12. 

Casella JF, Casella SJ, Hollands JA, Caldwell JE and Cooper JA: Isolation and characterization of cDNA encoding the alpha subunit of Cap Z(36/32), an actin-capping protein from the Z line of skeletal muscle. Proc Natl Acad Sci USA. 86:5800–5804. 1989. View Article : Google Scholar : PubMed/NCBI

13. 

Barron-Casella EA, Torres MA, Scherer SW, Heng HH, Tsui LC and Casella JF: Sequence analysis and chromosomal localization of human Cap Z. Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families. J Biol Chem. 270:21472–21479. 1995. View Article : Google Scholar

14. 

Cooper JA, Caldwell JE, Gattermeir DJ, Torres MA, Amatruda JF and Casella JF: Variant cDNAs encoding proteins similar to the alpha subunit of chicken CapZ. Cell Motil Cytoskeleton. 18:204–214. 1991. View Article : Google Scholar : PubMed/NCBI

15. 

Tanaka H, Yoshimura Y, Nishina Y, Nozaki M, Nojima H and Nishimune Y: Isolation and characterization of cDNA clones specifically expressed in testicular germ cells. FEBS Lett. 355:4–10. 1994. View Article : Google Scholar : PubMed/NCBI

16. 

Schafer DA, Korshunova YO, Schroer TA and Cooper JA: Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. J Cell Biol. 127:453–465. 1994. View Article : Google Scholar : PubMed/NCBI

17. 

Hart MC, Korshunova YO and Cooper JA: Mapping of the mouse actin capping protein alpha subunit genes and pseudo-genes. Genomics. 39:264–270. 1997. View Article : Google Scholar : PubMed/NCBI

18. 

Von Bulow M, Rackwitz HR, Zimbelmann R and Franke WW: CP beta3, a novel isoform of an actin-binding protein, is a component of the cytoskeletal calyx of the mammalian sperm head. Exp Cell Res. 233:216–224. 1997.PubMed/NCBI

19. 

Nachmias VT, Golla R, Casella JF and Barron-Casella E: Cap Z, a calcium insensitive capping protein in resting and activated platelets. FEBS Lett. 378:258–262. 1996. View Article : Google Scholar : PubMed/NCBI

20. 

Barkalow K, Witke W, Kwiatkowski DJ and Hartwig JH: Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J Cell Biol. 134:389–399. 1996. View Article : Google Scholar : PubMed/NCBI

21. 

Kimura M, Tsuda H, Morita D, et al: A proposal for diagnostically meaningful criteria to classify increased epidermal growth factor receptor and c-erbB-2 gene copy numbers in gastric carcinoma, based on correlation of fluorescence in situ hybridization and immunohistochemical measurements. Virchows Arch. 445:255–262. 2004. View Article : Google Scholar

22. 

Koike N, Todoroki T, Komano H, et al: Invasive potentials of gastric carcinoma cell lines: role of alpha 2 and alpha 6 integrins in invasion. J Cancer Res Clin Oncol. 123:310–316. 1997.PubMed/NCBI

23. 

Lee HS and Kim WH: Tissue array methods for high-throughput clinicopathologic research. Cancer Res Treat. 38:1–6. 2006. View Article : Google Scholar : PubMed/NCBI

24. 

Ikota H, Kinjo S, Yokoo H and Nakazato Y: Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology. Acta Neuropathol. 111:475–482. 2006. View Article : Google Scholar : PubMed/NCBI

25. 

Ou K, Yu K, Kesuma D, et al: Novel breast cancer biomarkers identified by integrative proteomic and gene expression mapping. J Proteome Res. 7:1518–1528. 2008. View Article : Google Scholar : PubMed/NCBI

26. 

Lee HS, Cho SB, Lee HE, et al: Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res. 13:4154–4163. 2007. View Article : Google Scholar : PubMed/NCBI

27. 

Kim MA, Lee HS, Lee HE, Kim JH, Yang HK and Kim WH: Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma. Histopathology. 54:442–451. 2009. View Article : Google Scholar : PubMed/NCBI

28. 

Lo WY, Lai CC, Hua CH, et al: S100A8 is identified as a biomarker of HPV18-infected oral squamous cell carcinomas by suppression subtraction hybridization, clinical proteomics analysis, and immunohistochemistry staining. J Proteome Res. 6:2143–2151. 2007. View Article : Google Scholar

29. 

Mueller HW, Michel A, Heckel D, et al: Identification of an amplified gene cluster in glioma including two novel amplified genes isolated by exon trapping. Hum Genet. 101:190–197. 1997. View Article : Google Scholar : PubMed/NCBI

30. 

Kellner R, Lichtenfels R, Atkins D, et al: Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance. Proteomics. 2:1743–1751. 2002. View Article : Google Scholar : PubMed/NCBI

31. 

Amatruda JF and Cooper JA: Purification, characterization, and immunofluorescence localization of Saccharomyces cerevisiae capping protein. J Cell Biol. 117:1067–1076. 1992. View Article : Google Scholar : PubMed/NCBI

32. 

Schafer DA, Hug C and Cooper JA: Inhibition of CapZ during myofibrillogenesis alters assembly of actin filaments. J Cell Biol. 128:61–70. 1995. View Article : Google Scholar : PubMed/NCBI

33. 

Hug C, Jay PY, Reddy I, et al: Capping protein levels influence actin assembly and cell motility in dictyostelium. Cell. 81:591–600. 1995. View Article : Google Scholar : PubMed/NCBI

34. 

Loisel TP, Boujemaa R, Pantaloni D and Carlier MF: Reconstitution of actin-based motility of Listeria and Shigella using pure proteins. Nature. 401:613–616. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee Y, Jeong S, Hong S, Cho B, Ha W, Park S, Choi S, Jung E, Ju Y, Jeong C, Jeong C, et al: Prognostic value of CAPZA1 overexpression in gastric cancer. Int J Oncol 42: 1569-1577, 2013.
APA
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S. ... Ko, G.H. (2013). Prognostic value of CAPZA1 overexpression in gastric cancer. International Journal of Oncology, 42, 1569-1577. https://doi.org/10.3892/ijo.2013.1867
MLA
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S., Choi, S., Jung, E., Ju, Y., Jeong, C., Kim, J. W., Lee, C. W., Yoo, J., Ko, G. H."Prognostic value of CAPZA1 overexpression in gastric cancer". International Journal of Oncology 42.5 (2013): 1569-1577.
Chicago
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S., Choi, S., Jung, E., Ju, Y., Jeong, C., Kim, J. W., Lee, C. W., Yoo, J., Ko, G. H."Prognostic value of CAPZA1 overexpression in gastric cancer". International Journal of Oncology 42, no. 5 (2013): 1569-1577. https://doi.org/10.3892/ijo.2013.1867
Copy and paste a formatted citation
x
Spandidos Publications style
Lee Y, Jeong S, Hong S, Cho B, Ha W, Park S, Choi S, Jung E, Ju Y, Jeong C, Jeong C, et al: Prognostic value of CAPZA1 overexpression in gastric cancer. Int J Oncol 42: 1569-1577, 2013.
APA
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S. ... Ko, G.H. (2013). Prognostic value of CAPZA1 overexpression in gastric cancer. International Journal of Oncology, 42, 1569-1577. https://doi.org/10.3892/ijo.2013.1867
MLA
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S., Choi, S., Jung, E., Ju, Y., Jeong, C., Kim, J. W., Lee, C. W., Yoo, J., Ko, G. H."Prognostic value of CAPZA1 overexpression in gastric cancer". International Journal of Oncology 42.5 (2013): 1569-1577.
Chicago
Lee, Y., Jeong, S., Hong, S., Cho, B., Ha, W., Park, S., Choi, S., Jung, E., Ju, Y., Jeong, C., Kim, J. W., Lee, C. W., Yoo, J., Ko, G. H."Prognostic value of CAPZA1 overexpression in gastric cancer". International Journal of Oncology 42, no. 5 (2013): 1569-1577. https://doi.org/10.3892/ijo.2013.1867
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