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Article

Insight into Sweet's syndrome and associated-malignancy: A review of the current literature

  • Authors:
    • Shahzad Raza
    • Robert S. Kirkland
    • Anand A. Patel
    • James R. Shortridge
    • Carl Freter
  • View Affiliations / Copyright

    Affiliations: Division of Hematology and Oncology, Ellis Fischel Cancer Center, Columbia, MO 65203, USA, University of Missouri School of Medicine, Columbia, MO 65203, USA
  • Pages: 1516-1522
    |
    Published online on: March 28, 2013
       https://doi.org/10.3892/ijo.2013.1874
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Abstract

Sweet's syndrome (acute febrile neutrophilic dermatosis) is an infrequent skin disease characterized by sudden onset of fever, leucocytosis and erythematous plaques or nodules infiltrated by neutrophils. There are three main clinical settings in which Sweet's syndrome has been described: classical or idiopathic Sweet's syndrome, malignancy-associated Sweet's syndrome and drug-induced Sweet's syndrome. Classical Sweet's is often preceded by an upper respiratory tract infection and may be associated with inflammatory bowel disease and pregnancy. Approximately 21% of patients have an associated malignancy, most commonly hematological disease. The syndrome may occur as a paraneoplastic accompaniment to established cancer or may be a first sign of malignancy or its recurrence. The incidence is said to be increasing in recent years due to the frequent use of growth factors in cancer patients. Several anticancer agents including all-trans-retinoic acid proteosome inhibitors, hypomethylating agents, tyrosine kinase inhibitors and lenalidomide are potential harbingers of Sweet's syndrome. Unfortunately, little is known about the pathophysiology of Sweet's syndrome and there are no established guidelines for treatment of malignancy-associated Sweet's syndrome. Systemic corticosteroids are the mainstay of treatment. Sweet's syndrome caused by anticancer agents sometimes involves withdrawal or temporary discontinuation of anticancer agents, use of systemic corticosteroids and/or rechallenge with either with the same anticancer agents or different agents. This report provides insights into the pathophysiology, clinical presentation, diagnostic work, differential diagnosis and management of malignancy-associated Sweet's syndrome published in reported cases.
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Copy and paste a formatted citation
Spandidos Publications style
Raza S, Kirkland RS, Patel AA, Shortridge JR and Freter C: Insight into Sweet's syndrome and associated-malignancy: A review of the current literature. Int J Oncol 42: 1516-1522, 2013.
APA
Raza, S., Kirkland, R.S., Patel, A.A., Shortridge, J.R., & Freter, C. (2013). Insight into Sweet's syndrome and associated-malignancy: A review of the current literature. International Journal of Oncology, 42, 1516-1522. https://doi.org/10.3892/ijo.2013.1874
MLA
Raza, S., Kirkland, R. S., Patel, A. A., Shortridge, J. R., Freter, C."Insight into Sweet's syndrome and associated-malignancy: A review of the current literature". International Journal of Oncology 42.5 (2013): 1516-1522.
Chicago
Raza, S., Kirkland, R. S., Patel, A. A., Shortridge, J. R., Freter, C."Insight into Sweet's syndrome and associated-malignancy: A review of the current literature". International Journal of Oncology 42, no. 5 (2013): 1516-1522. https://doi.org/10.3892/ijo.2013.1874
Copy and paste a formatted citation
x
Spandidos Publications style
Raza S, Kirkland RS, Patel AA, Shortridge JR and Freter C: Insight into Sweet's syndrome and associated-malignancy: A review of the current literature. Int J Oncol 42: 1516-1522, 2013.
APA
Raza, S., Kirkland, R.S., Patel, A.A., Shortridge, J.R., & Freter, C. (2013). Insight into Sweet's syndrome and associated-malignancy: A review of the current literature. International Journal of Oncology, 42, 1516-1522. https://doi.org/10.3892/ijo.2013.1874
MLA
Raza, S., Kirkland, R. S., Patel, A. A., Shortridge, J. R., Freter, C."Insight into Sweet's syndrome and associated-malignancy: A review of the current literature". International Journal of Oncology 42.5 (2013): 1516-1522.
Chicago
Raza, S., Kirkland, R. S., Patel, A. A., Shortridge, J. R., Freter, C."Insight into Sweet's syndrome and associated-malignancy: A review of the current literature". International Journal of Oncology 42, no. 5 (2013): 1516-1522. https://doi.org/10.3892/ijo.2013.1874
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