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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma

  • Authors:
    • Yong-Wan Kim
    • Su Mi Bae
    • Yong Wook Kim
    • Dong Choon Park
    • Keun-Ho Lee
    • Hai-Bo Liu
    • In-Wook Kim
    • Chun Keun Jang
    • Woong Shick Ahn
  • View Affiliations / Copyright

    Affiliations: Catholic Research Institutes of Medical Science, Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, Republic of Korea, Department of Obstetrics and Gynecology, College of Medicine, Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, Republic of Korea, Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
  • Pages: 539-547
    |
    Published online on: May 27, 2013
       https://doi.org/10.3892/ijo.2013.1961
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Abstract

There is an urgent need for molecular marker studies of adenocarcinoma (AC) and squamous cell carcinoma (SCC) of the uterine cervix. This study utilized oligomicroarray and pathway analyses to characterize a transcriptomic signature with molecular networks associated with AC and SCC. A 10K oligomicroarray was used to identify potential transcripts that were differentially expressed in cervical cancers from 28 patients and common reference RNAs from 17 different normal cervixes. Molecular networks were correlated using genomics tools to globally explore cellular pathways. Gene expression levels of 46 transcripts separated cancer samples into AC and SCC groups. Genes including: KRT17, IGFBP2, CALCA and VIPR1 were differentially expressed in AC and SCC. In addition, we identified a transcriptomic signature that predicted tumor classification and progression based upon its cellular processes. The downregulated signatures for SCC were cell death of pheochromocytoma cells (P=0.0037), apoptosis of neurons (P=0.009) and damage to DNA (P=0.0038). By contrast, the upregulated molecular signatures in AC were immunological disorder (P=0.006), splenomegaly (P=0.0053) and hepatic system disorder (P=0.006). The G2/M DNA damage checkpoint regulation pathway (P=0.05) was found to be significantly linked to IGF1R as a new regulatory component of a putative cytoplasmic signaling cascade in SCC. By contrast, the antigen presenting canonical pathway (P=0.038) appeared to be linked to PPARγ in AC. Taken together, these experiments provide important new information regarding the role of molecular networks in mediating SCC and AC, possibly through two independent pathways, and contribute to provide new targets for the prevention and treatment of cervical cancer.
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1. 

Bulk S, Visser O, Rozendaal L, Verheijen RH and Meijer CJ: Cervical cancer in the Netherlands 1989–1998: decrease of squamous cell carcinoma in older women, increase of adenocarcinoma in younger women. Int J Cancer. 113:1005–1009. 2005.

2. 

International Collaboration of Epidemiological Studies of Cervical Cancer: Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer. 120:885–891. 2007. View Article : Google Scholar

3. 

Ciapponi A, Bardach A, Glujovsky D, Gibbons L and Picconi MA: Type-specific HPV prevalence in cervical cancer and high-grade lesions in Latin America and the Caribbean: systematic review and meta-analysis. PLoS One. 6:e254932011. View Article : Google Scholar : PubMed/NCBI

4. 

Clifford GM, Smith JS, Plummer M, Munoz N and Franceschi S: Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer. 88:63–73. 2003. View Article : Google Scholar : PubMed/NCBI

5. 

Castellsague X, Diaz M, de Sanjose S, et al: Worldwide human papillomavirus etiology of cervical adenocarcinoma and its cofactors: implications for screening and prevention. J Natl Cancer Inst. 98:303–315. 2006. View Article : Google Scholar

6. 

Plummer M, Herrero R, Franceschi S, et al: Smoking and cervical cancer: pooled analysis of the IARC multi-centric case-control study. Cancer Causes Control. 14:805–814. 2003. View Article : Google Scholar : PubMed/NCBI

7. 

Wingo SN, Gallardo TD, Akbay EA, et al: Somatic LKB1 mutations promote cervical cancer progression. PLoS One. 4:e51372009. View Article : Google Scholar : PubMed/NCBI

8. 

Wessels JM, Edwards AK, Zettler C and Tayade C: Selection and validation of reference genes for miRNA expression studies during porcine pregnancy. PLoS One. 6:e289402011. View Article : Google Scholar : PubMed/NCBI

9. 

Yang IV, Chen E, Hasseman JP, et al: Within the fold: assessing differential expression measures and reproducibility in microarray assays. Genome Biol. 3:research00622002.PubMed/NCBI

10. 

Bae SM, Lee CH, Cho YL, et al: Two-dimensional gel analysis of protein expression profile in squamous cervical cancer patients. Gynecol Oncol. 99:26–35. 2005. View Article : Google Scholar : PubMed/NCBI

11. 

Smedts F, Ramaekers F, Troyanovsky S, et al: Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia. Am J Pathol. 140:601–612. 1992.PubMed/NCBI

12. 

Zumkeller W: IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth? Mol Pathol. 54:285–288. 2001. View Article : Google Scholar : PubMed/NCBI

13. 

Reubi JC: In vitro identification of vasoactive intestinal peptide receptors in human tumors: implications for tumor imaging. J Nucl Med. 36:1846–1853. 1995.

14. 

Nakanuma Y, Kouda W, Nakano T, Uneno K, Tachibana S and Araki I: A case report of early idiopathic portal hypertension. Pathol Res Pract. 197:759–767. 2001. View Article : Google Scholar : PubMed/NCBI

15. 

Iizuka N, Oka M, Yamada-Okabe H, et al: Comparison of gene expression profiles between hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma by oligonucleotide microarray data on the basis of a supervised learning method. Cancer Res. 62:3939–3944. 2002.

16. 

Wyllie AH: Apoptosis and carcinogenesis. Eur J Cell Biol. 73:189–197. 1997.

17. 

Dixon BP, Henry J, Siroky BJ, Chu A, Groen PA and Bissler JJ: Cell cycle control and DNA damage response of conditionally immortalized urothelial cells. PLoS One. 6:e165952011. View Article : Google Scholar : PubMed/NCBI

18. 

Luk SC, Siu SW, Lai CK, Wu YJ and Pang SF: Cell cycle arrest by a natural product via G2/M checkpoint. Int J Med Sci. 2:64–69. 2005. View Article : Google Scholar : PubMed/NCBI

19. 

Choi HJ, Fukui M and Zhu BT: Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. PLoS One. 6:e243122011. View Article : Google Scholar : PubMed/NCBI

20. 

Gao Q, Srinivasan S, Boyer SN, Wazer DE and Band V: The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Mol Cell Biol. 19:733–744. 1999.PubMed/NCBI

21. 

Arai H, Ueno T, Tangoku A, et al: Detection of amplified oncogenes by genome DNA microarrays in human primary esophageal squamous cell carcinoma: comparison with conventional comparative genomic hybridization analysis. Cancer Genet Cytogenet. 146:16–21. 2003. View Article : Google Scholar

22. 

Schneider G, Weber A, Zechner U, et al: GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. Int J Cancer. 118:2405–2411. 2006. View Article : Google Scholar : PubMed/NCBI

23. 

Parvaresch S, Yesilkaya T, Baer K, Al-Hasani H and Klein HW: 14-3-3 binding to the IGF-1 receptor is mediated by serine auto-phosphorylation. FEBS Lett. 532:357–362. 2002. View Article : Google Scholar : PubMed/NCBI

24. 

Nakamura K, Hongo A, Kodama J, Miyagi Y, Yoshinouchi M and Kudo T: Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines. Cancer Res. 60:760–765. 2000.

25. 

Spence SL, Dey BR, Terry C, Albert P, Nissley P and Furlanetto RW: Interaction of 14-3-3 proteins with the insulin-like growth factor I receptor (IGFIR): evidence for a role of 14-3-3 proteins in IGFIR signaling. Biochem Biophys Res Commun. 312:1060–1066. 2003. View Article : Google Scholar : PubMed/NCBI

26. 

Fu H, Subramanian RR and Masters SC: 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol. 40:617–647. 2000. View Article : Google Scholar

27. 

Craparo A, Freund R and Gustafson TA: 14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner. J Biol Chem. 272:11663–11669. 1997. View Article : Google Scholar : PubMed/NCBI

28. 

Takashima T, Fujiwara Y, Higuchi K, et al: PPAR-γ ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. Int J Oncol. 19:465–471. 2001.

29. 

Yang WL and Frucht H: Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. Carcinogenesis. 22:1379–1383. 2001. View Article : Google Scholar : PubMed/NCBI

30. 

Hall JM and McDonnell DP: The molecular mechanisms underlying the proinflammatory actions of thiazolidinediones in human macrophages. Mol Endocrinol. 21:1756–1768. 2007. View Article : Google Scholar : PubMed/NCBI

31. 

Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P and Evans RM: PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med. 7:48–52. 2001. View Article : Google Scholar : PubMed/NCBI

32. 

Marx N, Kehrle B, Kohlhammer K, et al: PPAR activators as anti-inflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res. 90:703–710. 2002. View Article : Google Scholar : PubMed/NCBI

33. 

Shankaranarayanan P and Nigam S: IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor. J Immunol. 170:887–894. 2003. View Article : Google Scholar

34. 

Eichele K, Ramer R and Hinz B: R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclo oxygenase-2-dependent pathway. Pharm Res. 26:346–355. 2009.

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Copy and paste a formatted citation
Spandidos Publications style
Kim Y, Bae SM, Kim YW, Park DC, Lee K, Liu H, Kim I, Jang CK and Ahn WS: Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma. Int J Oncol 43: 539-547, 2013.
APA
Kim, Y., Bae, S.M., Kim, Y.W., Park, D.C., Lee, K., Liu, H. ... Ahn, W.S. (2013). Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma. International Journal of Oncology, 43, 539-547. https://doi.org/10.3892/ijo.2013.1961
MLA
Kim, Y., Bae, S. M., Kim, Y. W., Park, D. C., Lee, K., Liu, H., Kim, I., Jang, C. K., Ahn, W. S."Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma". International Journal of Oncology 43.2 (2013): 539-547.
Chicago
Kim, Y., Bae, S. M., Kim, Y. W., Park, D. C., Lee, K., Liu, H., Kim, I., Jang, C. K., Ahn, W. S."Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma". International Journal of Oncology 43, no. 2 (2013): 539-547. https://doi.org/10.3892/ijo.2013.1961
Copy and paste a formatted citation
x
Spandidos Publications style
Kim Y, Bae SM, Kim YW, Park DC, Lee K, Liu H, Kim I, Jang CK and Ahn WS: Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma. Int J Oncol 43: 539-547, 2013.
APA
Kim, Y., Bae, S.M., Kim, Y.W., Park, D.C., Lee, K., Liu, H. ... Ahn, W.S. (2013). Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma. International Journal of Oncology, 43, 539-547. https://doi.org/10.3892/ijo.2013.1961
MLA
Kim, Y., Bae, S. M., Kim, Y. W., Park, D. C., Lee, K., Liu, H., Kim, I., Jang, C. K., Ahn, W. S."Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma". International Journal of Oncology 43.2 (2013): 539-547.
Chicago
Kim, Y., Bae, S. M., Kim, Y. W., Park, D. C., Lee, K., Liu, H., Kim, I., Jang, C. K., Ahn, W. S."Target-based molecular signature characteristics of cervical adenocarcinoma and squamous cell carcinoma". International Journal of Oncology 43, no. 2 (2013): 539-547. https://doi.org/10.3892/ijo.2013.1961
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