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Article

Genetic differences between Asian and Caucasian chronic lymphocytic leukemia

  • Authors:
    • Norihiko Kawamata
    • Chimene Moreilhon
    • Takayuki Saitoh
    • Masamitsu Karasawa
    • Brian K. Bernstein
    • Aiko Sato-Otsubo
    • Seishi Ogawa
    • Sophie Raynaud
    • H. Phillip Koeffler
  • View Affiliations / Copyright

    Affiliations: Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA, Center Hospital, University of Nice, Nice, France, Gunma University, Maebashi, Gunma, Japan, University of Tokyo, Tokyo, Japan
  • Pages: 561-565
    |
    Published online on: May 27, 2013
       https://doi.org/10.3892/ijo.2013.1966
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Abstract

Chronic lymphocytic leukemia (CLL) is a common hematological malignancy in Western countries. However, this disease is very rare in Asian countries. It is not clear whether the mechanisms of development of CLL in Caucasians and Asians are the same. We compared genetic abnormalities in Asian and Caucasian CLL using 250k GeneChip arrays. Both Asian and Caucasian CLL had four common genetic abnormalities: deletion of 13q14.3, trisomy 12, abnormalities of ATM (11q) and abnormalities of 17p. Interestingly, trisomy 12 and deletion of 13q14.3 were mutually exclusive in both groups. We also found that deletions of miR 34b/34c (11q), caspase 1/4/5 (11q), Rb1 (13q) and DLC1 (8p) are common in both ethnic groups. Asian CLL more frequently had gain of 3q and 18q. These suggest that classic genomic changes in the Asian and Caucasina CLL are same. Further, we found amplification of IRF4 and deletion of the SP140/SP100 genes; these genes have been reported as CLL-associated genes by previous genome-wide-association study. We have found classic genomic abnormalities in Asian CLL as well as novel genomic alteration in CLL.
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Copy and paste a formatted citation
Spandidos Publications style
Kawamata N, Moreilhon C, Saitoh T, Karasawa M, Bernstein BK, Sato-Otsubo A, Ogawa S, Raynaud S and Koeffler HP: Genetic differences between Asian and Caucasian chronic lymphocytic leukemia. Int J Oncol 43: 561-565, 2013.
APA
Kawamata, N., Moreilhon, C., Saitoh, T., Karasawa, M., Bernstein, B.K., Sato-Otsubo, A. ... Koeffler, H.P. (2013). Genetic differences between Asian and Caucasian chronic lymphocytic leukemia. International Journal of Oncology, 43, 561-565. https://doi.org/10.3892/ijo.2013.1966
MLA
Kawamata, N., Moreilhon, C., Saitoh, T., Karasawa, M., Bernstein, B. K., Sato-Otsubo, A., Ogawa, S., Raynaud, S., Koeffler, H. P."Genetic differences between Asian and Caucasian chronic lymphocytic leukemia". International Journal of Oncology 43.2 (2013): 561-565.
Chicago
Kawamata, N., Moreilhon, C., Saitoh, T., Karasawa, M., Bernstein, B. K., Sato-Otsubo, A., Ogawa, S., Raynaud, S., Koeffler, H. P."Genetic differences between Asian and Caucasian chronic lymphocytic leukemia". International Journal of Oncology 43, no. 2 (2013): 561-565. https://doi.org/10.3892/ijo.2013.1966
Copy and paste a formatted citation
x
Spandidos Publications style
Kawamata N, Moreilhon C, Saitoh T, Karasawa M, Bernstein BK, Sato-Otsubo A, Ogawa S, Raynaud S and Koeffler HP: Genetic differences between Asian and Caucasian chronic lymphocytic leukemia. Int J Oncol 43: 561-565, 2013.
APA
Kawamata, N., Moreilhon, C., Saitoh, T., Karasawa, M., Bernstein, B.K., Sato-Otsubo, A. ... Koeffler, H.P. (2013). Genetic differences between Asian and Caucasian chronic lymphocytic leukemia. International Journal of Oncology, 43, 561-565. https://doi.org/10.3892/ijo.2013.1966
MLA
Kawamata, N., Moreilhon, C., Saitoh, T., Karasawa, M., Bernstein, B. K., Sato-Otsubo, A., Ogawa, S., Raynaud, S., Koeffler, H. P."Genetic differences between Asian and Caucasian chronic lymphocytic leukemia". International Journal of Oncology 43.2 (2013): 561-565.
Chicago
Kawamata, N., Moreilhon, C., Saitoh, T., Karasawa, M., Bernstein, B. K., Sato-Otsubo, A., Ogawa, S., Raynaud, S., Koeffler, H. P."Genetic differences between Asian and Caucasian chronic lymphocytic leukemia". International Journal of Oncology 43, no. 2 (2013): 561-565. https://doi.org/10.3892/ijo.2013.1966
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