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Article

Rho/Rho-associated kinase pathway in glaucoma (Review)

  • Authors:
    • Jing Wang
    • Xiaohong Liu
    • Yisheng Zhong
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, P.R. China
  • Pages: 1357-1367
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    Published online on: September 16, 2013
       https://doi.org/10.3892/ijo.2013.2100
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Abstract

The Rho/ROCK pathway plays important roles in the modulation of the cytoskeletal integrity of cells, the synthesis of extracellular matrix components in the aqueous humor outflow tissue and the permeability of Schlemm's canal endothelial cells. The activation of the Rho/ROCK pathway results in trabecular meshwork (TM) contraction, and the inhibition of this pathway would provoke relaxation of TM with subsequent increase in outflow facility and, thereby, decrease intraocular pressure (IOP). ROCK inhibitors also serve as potent anti‑scarring agents via inhibition of transdifferentiation of tenon fibroblasts into myofibroblasts. Furthermore, the RhoA/ROCK pathway is involved in optic nerve neuroprotection. Inactivation of Rho/ROCK signaling increase ocular blood flow, improve retinal ganglion cell (RGC) survival and promote RGC axon regeneration. Considering the IOP modulation, potent bleb anti-scarring effect and neuroprotective properties of ROCK inhibitors, the Rho/ROCK pathway is an attractive target for anti-glaucoma therapy, and it may be used for human therapy in the near future.
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1. 

Weinreb RN and Khaw PT: Primary open-angle glaucoma. Lancet. 363:1711–1720. 2004. View Article : Google Scholar : PubMed/NCBI

2. 

Quigley HA: Glaucoma. Lancet. 377:1367–1377. 2011. View Article : Google Scholar : PubMed/NCBI

3. 

Sommer A: Intraocular pressure and glaucoma. Am J Ophthalmol. 107:186–188. 1989. View Article : Google Scholar

4. 

Tielsch JM, Sommer A, Katz J, Royall RM, Quigley HA and Javitt J: Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA. 266:369–374. 1991. View Article : Google Scholar : PubMed/NCBI

5. 

Klein BE, Klein R, Sponsel WE, Franke T, Cantor LB, Martone J and Menage MJ: Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmology. 99:1499–1504. 1992. View Article : Google Scholar : PubMed/NCBI

6. 

Mitchell P, Smith W, Attebo K and Healey PR: Prevalence of open-angle glaucoma in Australia. The Blue Mountains Eye Study. Ophthalmology. 103:1661–1669. 1996. View Article : Google Scholar : PubMed/NCBI

7. 

Collaborative Normal-Tension Glaucoma Study Group: Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am J Ophthalmol. 126:487–497. 1998. View Article : Google Scholar

8. 

Collaborative Normal-Tension Glaucoma Study Group: The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol. 126:498–505. 1998. View Article : Google Scholar : PubMed/NCBI

9. 

The AGIS Investigators: The advanced glaucoma intervention study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 130:429–440. 2000. View Article : Google Scholar

10. 

Lichter PR, Musch DC, Gillespie BW, Guire KE, Janz NK, Wren PA and Mills RP: Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology. 108:1943–1953. 2001. View Article : Google Scholar

11. 

Gordon MO, Beiser JA, Brandt JD, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK II, Wilson MR and Kass MA: The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 120:714–720. 2002. View Article : Google Scholar : PubMed/NCBI

12. 

Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR and Gordon MO: The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 120:701–713. 2002. View Article : Google Scholar

13. 

Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L and Komaroff E: Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 121:48–56. 2003. View Article : Google Scholar : PubMed/NCBI

14. 

Hernandez MR: The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 19:297–321. 2000. View Article : Google Scholar : PubMed/NCBI

15. 

Burgoyne CF: A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma. Exp Eye Res. 93:120–132. 2011. View Article : Google Scholar : PubMed/NCBI

16. 

Lutjen-Drecoll E: Functional morphology of the trabecular meshwork in primate eyes. Prog Retin Eye Res. 18:91–119. 1999. View Article : Google Scholar : PubMed/NCBI

17. 

Tan JC, Peters DM and Kaufman PL: Recent developments in understanding the pathophysiology of elevated intraocular pressure. Curr Opin Ophthalmol. 17:168–174. 2006.PubMed/NCBI

18. 

Gabelt BT and Kaufman PL: Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 24:612–637. 2005. View Article : Google Scholar : PubMed/NCBI

19. 

Grant WM: Experimental aqueous perfusion in enucleated human eyes. Arch Ophthalmol. 69:783–801. 1963. View Article : Google Scholar : PubMed/NCBI

20. 

Johnson M: What controls aqueous humour outflow resistance? Exp Eye Res. 82:545–557. 2006. View Article : Google Scholar : PubMed/NCBI

21. 

Tamm ER: The trabecular meshwork outflow pathways: Structural and functional aspects. Exp Eye Res. 88:648–655. 2009. View Article : Google Scholar : PubMed/NCBI

22. 

Kumar J and Epstein DL: Rho GTPase-mediated cytoskeletal organization in Schlemm’s canal cells play a critical role in the regulation of aqueous humor outflow facility. J Cell Biochem. 112:600–606. 2011.PubMed/NCBI

23. 

Ethier CR: The inner wall of Schlemm’s canal. Exp Eye Res. 74:161–172. 2002.

24. 

Wiederholt M, Thieme H and Stumpff F: The regulation of trabecular meshwork and ciliary muscle contractility. Prog Retin Eye Res. 19:271–295. 2000. View Article : Google Scholar : PubMed/NCBI

25. 

Lutjen-Drecoll E: Morphological changes in glaucomatous eyes and the role of TGF β2 for the pathogenesis of the disease. Exp Eye Res. 81:1–4. 2005.

26. 

Fuchshofer R and Tamm ER: The role of TGF-β in the pathogenesis of primary open-angle glaucoma. Cell Tissue Res. 347:279–290. 2012.

27. 

Bradley JM, Vranka J, Colvis CM, Conger DM, Alexander JP, Fisk AS, Samples JR and Acott TS: Effect of matrix metalloproteinases activity on outflow in perfused human organ culture. Invest Ophthalmol Vis Sci. 39:2649–2658. 1998.PubMed/NCBI

28. 

Tian B, Geiger B, Epstein DL and Kaufman PL: Cytoskeletal involvement in the regulation of aqueous humor outflow. Invest Ophthalmol Vis Sci. 41:619–623. 2000.PubMed/NCBI

29. 

Tian B, Gabelt BT, Geiger B and Kaufman PL: The role of the actomyosin system in regulating trabecular fluid outflow. Exp Eye Res. 88:713–717. 2009. View Article : Google Scholar : PubMed/NCBI

30. 

Last JA, Pan T, Ding Y, Reilly CM, Keller K, Acott TS, Fautsch MP, Murphy CJ and Russell P: Elastic modulus determination of normal and glaucomatous human trabecular meshwork. Invest Ophthalmol Vis Sci. 52:2147–2152. 2011. View Article : Google Scholar : PubMed/NCBI

31. 

Erschbamer MK, Hofstetter CP and Olson L: RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury. J Comp Neurol. 484:224–233. 2005. View Article : Google Scholar : PubMed/NCBI

32. 

Etienne-Manneville S and Hall A: Rho GTPases in cell biology. Nature. 420:629–635. 2002. View Article : Google Scholar

33. 

Nakagawa O, Fujisawa K, Ishizaki T, Saito Y, Nakao K and Narumiya S: ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice. FEBS Lett. 392:189–193. 1996. View Article : Google Scholar : PubMed/NCBI

34. 

Riento K and Ridley AJ: Rocks: multifunctional kinases in cell behaviour. Nat Rev Mol Cell Biol. 4:446–456. 2003. View Article : Google Scholar : PubMed/NCBI

35. 

Leung T, Chen XQ, Manser E and Lim L: The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol. 16:5313–5327. 1996.PubMed/NCBI

36. 

Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A and Olson MF: Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol. 3:339–345. 2001. View Article : Google Scholar : PubMed/NCBI

37. 

Sebbagh M, Renvoizé C, Hamelin J, Riché N, Bertoglio J and Bréard J: Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol. 3:346–352. 2001. View Article : Google Scholar : PubMed/NCBI

38. 

Sebbagh M, Hamelin J, Bertoglio J, Solary E and Bréard J: Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner. J Exp Med. 201:465–471. 2005. View Article : Google Scholar : PubMed/NCBI

39. 

Van Aelst L and D’Souza-Schorey C: Rho GTPases and signaling networks. Genes Dev. 11:2295–2322. 1997.PubMed/NCBI

40. 

Ridley AJ, Paterson HF, Johnston CL, Diekmann D and Hall A: The small GTP-binding protein rho regulates growth factor-induced membrane ruffling. Cell. 70:401–410. 1992. View Article : Google Scholar : PubMed/NCBI

41. 

Ridley AJ and Hall A: Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO J. 13:2600–2610. 1994.PubMed/NCBI

42. 

Nobes C and Hall A: Regulation and function of the Rho subfamily of small GTPases. Curr Opin Genet Dev. 4:77–81. 1994. View Article : Google Scholar : PubMed/NCBI

43. 

Takai Y, Sasaki T, Tanaka K and Nakanishi H: Rho as a regulator of the cytoskeleton. Trends Biochem Sci. 20:227–231. 1995. View Article : Google Scholar : PubMed/NCBI

44. 

Paterson HF, Self AJ, Garrett MD, Just I, Aktories K and Hall A: Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol. 111:1001–1007. 1990. View Article : Google Scholar : PubMed/NCBI

45. 

Hirata K, Kikuchi A, Sasaki T, Kuroda S, Kaibuchi K, Matsuura Y, Seki H, Saida K and Takai Y: Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem. 267:8719–8722. 1992.PubMed/NCBI

46. 

Narumiya S: The small GTPase Rho: cellular functions and signal transduction. J Biochem (Tokyo). 120:215–228. 1996. View Article : Google Scholar : PubMed/NCBI

47. 

Gong MC, Iizuka K, Nixon G, Browne JP, Hall A, Eccleston JF, Sugai M, Kobayashi S, Somlyo AV and Somlyo AP: Role of guanine nucleotide-binding proteins - ras-family or trimeric proteins or both - in Ca2+ sensitization of smooth muscle. Proc Natl Acad Sci USA. 93:1340–1345. 1996. View Article : Google Scholar : PubMed/NCBI

48. 

Narumiya S, Ishizaki T and Watanabe N: Rho effectors and reorganization of actin cytoskeleton. FEBS Lett. 410:68–72. 1997. View Article : Google Scholar : PubMed/NCBI

49. 

Kaibuchi K, Kuroda S and Amano M: Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem. 68:459–486. 1999. View Article : Google Scholar : PubMed/NCBI

50. 

Somlyo AP and Somlyo AV: Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 522:177–185. 2000. View Article : Google Scholar : PubMed/NCBI

51. 

Fukata Y, Amano M and Kaibuchi K: Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci. 22:32–39. 2001. View Article : Google Scholar : PubMed/NCBI

52. 

Nakayama M, Amano M, Katsumi A, Kaneko T, Kawabata S, Takefuji M and Kaibuchi K: Rho-kinase and myosin II activities are required for cell type and environment specific migration. Genes Cells. 10:107–117. 2005. View Article : Google Scholar : PubMed/NCBI

53. 

Nakajima E, Nakajima T, Minagawa Y, Shearer TR and Azuma M: Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes. J Pharm Sci. 94:701–708. 2005. View Article : Google Scholar : PubMed/NCBI

54. 

Amano M, Nakayama M and Kaibuchi K: Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken). 67:545–554. 2010. View Article : Google Scholar : PubMed/NCBI

55. 

Tan HB, Zhong YS, Cheng Y and Shen X: Rho/ROCK pathway and neural regeneration: a potential therapeutic target for central nervous system and optic nerve damage. Int J Ophthalmol. 4:652–657. 2011.PubMed/NCBI

56. 

Asano T, Ikegaki I, Satoh S, Suzuki Y, Shibuya M, Takayasu M and Hidaka H: Mechanism of action of a novel antivasospasm drug, HA1077. J Pharmacol Exp Ther. 241:1033–1040. 1987.PubMed/NCBI

57. 

Asano T, Suzuki T, Tsuchiya M, Satoh S, Ikegaki I, Shibuya M, Suzuki Y and Hidaka H: Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. Br J Pharmacol. 98:1091–1100. 1989. View Article : Google Scholar : PubMed/NCBI

58. 

Honjo M, Inatani M, Kido N, Sawamura T, Yue BY, Honda Y and Tanihara H: A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes. Exp Eye Res. 75:135–142. 2002. View Article : Google Scholar : PubMed/NCBI

59. 

Yoneda A, Multhaupt HA and Couchman JR: The Rho kinases I and II regulate different aspects of myosin II activity. J Cell Biol. 170:443–453. 2005. View Article : Google Scholar : PubMed/NCBI

60. 

Wang Y, Zheng XR, Riddick N, Bryden M, Baur W, Zhang X and Surks HK: ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. Circ Res. 104:531–540. 2009. View Article : Google Scholar : PubMed/NCBI

61. 

Hartshorne DJ: Myosin phosphatase: subunits and interactions. Acta Physiol Scand. 164:483–493. 1998. View Article : Google Scholar : PubMed/NCBI

62. 

Pfitzer G: Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol. 91:497–503. 2001.PubMed/NCBI

63. 

Harnett KM and Biancani P: Calcium-dependent and calcium-independent contractions in smooth muscles. Am J Med. 115(Suppl 3A): 24S–30S. 2003. View Article : Google Scholar : PubMed/NCBI

64. 

Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A and Kaibuchi K: Regulation of myosin phosphatase by rho and rho-associated kinase (rho-kinase). Science. 273:245–248. 1996. View Article : Google Scholar : PubMed/NCBI

65. 

Wettschureck N and Offermanns S: Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med. 80:629–638. 2002. View Article : Google Scholar : PubMed/NCBI

66. 

Somlyo AP and Somlyo AV: Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev. 83:1325–1358. 2003.

67. 

Hall A: Rho GTPases and the actin cytoskeleton. Science. 279:509–514. 1998. View Article : Google Scholar

68. 

Ridley AJ: Rho GTPases and cell migration. J Cell Sci. 114:2713–2722. 2001.PubMed/NCBI

69. 

Jaffe AB and Hall A: Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 21:247–269. 2005. View Article : Google Scholar : PubMed/NCBI

70. 

Spindler V, Schlegel N and Waschke J: Role of GTPases in control of microvascular permeability. Cardiovasc Res. 87:243–253. 2010. View Article : Google Scholar : PubMed/NCBI

71. 

Thieme H, Nuskovski M, Nass JU, Pleyer U, Strauss O and Wiederholt M: Mediation of calcium-independent contraction in trabecular meshwork through protein kinase c and rho-A. Invest Ophthalmol Vis Sci. 41:4240–4246. 2000.PubMed/NCBI

72. 

Honjo M, Tanihara H, Inatani M, Kido N, Sawamura T, Yue BY, Narumiya S and Honda Y: Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 42:137–144. 2001.PubMed/NCBI

73. 

Rao PV, Deng PF, Kumar J and Epstein DL: Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632. Invest Ophthalmol Vis Sci. 42:1029–1037. 2001.PubMed/NCBI

74. 

Goldhagen B, Proia AD, Epstein DL and Rao PV: Elevated levels of RhoA in the optic nerve head of human eyes with glaucoma. J Glaucoma. 21:530–538. 2012. View Article : Google Scholar : PubMed/NCBI

75. 

Epstein DL, Rowlette LL and Roberts BC: Acto-myosin drug effects and aqueous outflow function. Invest Ophthalmol Vis Sci. 40:74–81. 1999.PubMed/NCBI

76. 

Rao PV, Deng P, Sasaki Y and Epstein DL: Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility. Exp Eye Res. 80:197–206. 2005. View Article : Google Scholar : PubMed/NCBI

77. 

Geiger B, Yehuda-Levenberg S and Bershadsky AD: Molecular interactions in the submembrane plaque of cell-cell and cell-matrix adhesions. Acta Anat (Basel). 154:46–62. 1995. View Article : Google Scholar : PubMed/NCBI

78. 

Rosenthal R, Choritz L, Schlott S, Bechrakis NE, Jaroszewski J, Wiederholt M and Thieme H: Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork. Exp Eye Res. 80:837–845. 2005. View Article : Google Scholar : PubMed/NCBI

79. 

Renieri G, Choritz L, Rosenthal R, Meissner S, Pfeiffer N and Thieme H: Effects of endothelin-1 on calcium-independent contraction of bovine trabecular meshwork. Graefes Arch Clin Exp Ophthalmol. 246:1107–1115. 2008. View Article : Google Scholar : PubMed/NCBI

80. 

Lu Z, Overby DR, Scott PA, Freddo TF and Gong H: The mechanism of increasing outflow facility by rho-kinase inhibition with Y-27632 in bovine eyes. Exp Eye Res. 86:271–281. 2008. View Article : Google Scholar : PubMed/NCBI

81. 

Johnstone MA: The aqueous outflow system as a mechanical pump: evidence from examination of tissue and aqueous movement in human and non-human primates. J Glaucoma. 13:421–438. 2004. View Article : Google Scholar : PubMed/NCBI

82. 

Rao VP and Epstein DL: Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma. BioDrugs. 21:167–177. 2007. View Article : Google Scholar : PubMed/NCBI

83. 

WuDunn D: Mechanobiology of trabecular meshwork cells. Exp Eye Res. 88:718–723. 2009. View Article : Google Scholar : PubMed/NCBI

84. 

Wiederholt M, Bielka S, Schweig F, Lutjen-Drecoll E and Lepple-Wienhues A: Regulation of outflow rate and resistance in the perfused anterior segment of the bovine eye. Exp Eye Res. 61:223–234. 1995. View Article : Google Scholar : PubMed/NCBI

85. 

Honjo M, Inatani M, Kido N, Sawamura T, Yue BY, Honda Y and Tanihara H: Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. Arch Ophthalmol. 119:1171–1178. 2001. View Article : Google Scholar : PubMed/NCBI

86. 

Tokushige H, Inatani M, Nemoto S, Sakaki H, Katayama K, Uehata M and Tanihara H: Effects of topical administration of Y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci. 48:3216–3222. 2007. View Article : Google Scholar : PubMed/NCBI

87. 

Tanihara H, Inatani M, Honjo M, Tokushige H, Azuma J and Araie M: Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers. Arch Ophthalmol. 126:309–315. 2008. View Article : Google Scholar : PubMed/NCBI

88. 

Fukunaga T, Ikesugi K, Nishio M, Sugimoto M, Sasoh M, Hidaka H and Uji Y: The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading. Curr Eye Res. 34:42–47. 2009. View Article : Google Scholar : PubMed/NCBI

89. 

Gottanka J, Chan D, Eichhorn M, Lutjen-Drecoll E and Ethier CR: Effects of TGF-β2 in perfused human eyes. Invest Ophthalmol Vis Sci. 45:153–158. 2004.

90. 

Mettu PS, Deng PF, Misra UK, Gawdi G, Epstein DL and Rao PV: Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility. Invest Ophthalmol Vis Sci. 45:2263–2271. 2004. View Article : Google Scholar : PubMed/NCBI

91. 

Zhang M, Maddala R and Rao PV: Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork. Am J Physiol Cell Physiol. 295:C1057–C1070. 2008. View Article : Google Scholar : PubMed/NCBI

92. 

Waki M, Yoshida Y, Oka T and Azuma M: Reduction of intraocular pressure by topical administration of an inhibitor of the Rho-associated protein kinase. Curr Eye Res. 22:470–474. 2001. View Article : Google Scholar : PubMed/NCBI

93. 

Wiederholt M and Stumpff H: The trabecular meshwork and aqueous humor reabsorption. Curr Top Membr. 45:163–202. 1998. View Article : Google Scholar

94. 

Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M and Narumiya S: Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 389:990–994. 1997. View Article : Google Scholar : PubMed/NCBI

95. 

Iizuka K, Yoshii A, Samizo K, Tsukagoshi H, Ishizuka T, Dobashi K, Nakazawa T and Mori M: A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit trachea. Br J Pharmacol. 128:925–933. 1999. View Article : Google Scholar : PubMed/NCBI

96. 

Lütjen-Drecoll E, Futa R and Rohen JW: Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes. Invest Ophthalmol Vis Sci. 21:563–573. 1981.PubMed/NCBI

97. 

Yue BY: The extracellular matrix and its modulation in the trabecular meshwork. Surv Ophthalmol. 40:379–390. 1996. View Article : Google Scholar : PubMed/NCBI

98. 

Tamm ER and Fuchshofer R: What increases outflow resistance in primary open-angle glaucoma? Surv Ophthalmol. 52(Suppl 2): S101–S104. 2007. View Article : Google Scholar : PubMed/NCBI

99. 

Acott TS and Kelley MJ: Extracellular matrix in the trabecular meshwork. Exp Eye Res. 86:543–561. 2008. View Article : Google Scholar : PubMed/NCBI

100. 

Keller KE, Aga M, Bradley JM, Kelley MJ and Acott TS: Extracellular matrix turnover and outflow resistance. Exp Eye Res. 88:676–682. 2009. View Article : Google Scholar : PubMed/NCBI

101. 

Pattabiraman PP and Rao PV: Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol. 298:C749–763. 2010. View Article : Google Scholar : PubMed/NCBI

102. 

Nakamura Y, Hirano S, Suzuki K, Seki K, Sagara T and Nishida T: Signaling mechanism of TGF-β1-induced collagen contraction mediated by bovine trabecular meshwork cells. Invest Ophthalmol Vis Sci. 43:3465–3472. 2002.

103. 

Fleenor DL, Shepard AR, Hellberg PE, Jacobson N, Pang IH and Clark AF: TGFβ2-induced changes in human trabecular meshwork: implications for intraocular pressure. Invest Ophthalmol Vis Sci. 47:226–234. 2006.

104. 

Iyer P, Maddala R, Pattabiraman PP and Rao PV: Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow. Invest Ophthalmol Vis Sci. 53:4952–4962. 2012. View Article : Google Scholar : PubMed/NCBI

105. 

Bershadsky AD, Balaban NQ and Geiger B: Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol. 19:677–695. 2003. View Article : Google Scholar : PubMed/NCBI

106. 

Kaunas R, Nguyen P, Usami S and Chien S: Cooperative effects of Rho and mechanical stretch on stress fiber organization. Proc Natl Acad Sci USA. 102:15895–15900. 2005. View Article : Google Scholar : PubMed/NCBI

107. 

Shikata Y, Rios A, Kawkitinarong K, DePaola N, Garcia JG and Birukov KG: Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells. Exp Cell Res. 304:40–49. 2005. View Article : Google Scholar : PubMed/NCBI

108. 

Ingber DE: Cellular mechanotransduction: putting all the pieces together again. FASEB J. 20:811–827. 2006. View Article : Google Scholar : PubMed/NCBI

109. 

Tzima E: Role of small GTPases in endothelial cytoskeletal dynamics and the shear stress response. Circ Res. 98:176–185. 2006. View Article : Google Scholar : PubMed/NCBI

110. 

Schlunck G, Han H, Wecker T, Kampik D, Meyer-ter-Vehn T and Grehn F: Substrate rigidity modulates cell matrix interactions and protein expression in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 49:262–269. 2008. View Article : Google Scholar : PubMed/NCBI

111. 

Kameda T, Inoue T, Inatani M, Fujimoto T, Honjo M, Kasaoka N, Inoue-Mochita M, Yoshimura N and Tanihara H: The effect of Rho-associated protein kinase inhibitor on monkey Schlemm’s canal endothelial cells. Invest Ophthalmol Vis Sci. 53:3092–3103. 2012.PubMed/NCBI

112. 

Epstein DL, Freddo TF, Bassett-Chu S, Chung M and Karageuzian L: Influence of ethacrynic acid on outflow facility in the monkey and calf eye. Invest Ophthalmol Vis Sci. 28:2067–2075. 1987.PubMed/NCBI

113. 

Ethier CR, Read AT and Chan DW: Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes. Invest Ophthalmol Vis Sci. 47:1991–1998. 2006. View Article : Google Scholar : PubMed/NCBI

114. 

Inoue T, Pattabiraman PP, Epstein DL and Rao PV: Effects of chemical inhibition of N-WASP, a critical regulator of actin polymerization on aqueous humor outflow through the conventional pathway. Exp Eye Res. 90:360–367. 2010. View Article : Google Scholar : PubMed/NCBI

115. 

Bill A and Svedbergh B: Scanning electron microscopic studies of the trabecular meshwork and the canal of Schlemm - an attempt to localize the main resistance to outflow of aqueous humor in man. Acta Ophthalmol (Copenh). 50:295–320. 1972. View Article : Google Scholar : PubMed/NCBI

116. 

Liu Q, Wu K, Qiu X, Yang Y, Lin X and Yu M: siRNA silencing of gene expression in trabecular meshwork: RhoA siRNA reduces IOP in mice. Curr Mol Med. 12:1015–1027. 2012. View Article : Google Scholar : PubMed/NCBI

117. 

Tian B and Kaufman PL: Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculinA on outflow facility in monkeys. Exp Eye Res. 80:215–225. 2005. View Article : Google Scholar : PubMed/NCBI

118. 

Yu M, Chen X, Wang N, Cai S, Li N, Qiu J, Brandt CR, Kaufman PL and Liu X: H-1152 effects on intraocular pressure and trabecular meshwork morphology of rat eyes. J Ocul Pharmacol Ther. 24:373–379. 2008. View Article : Google Scholar : PubMed/NCBI

119. 

Nishio M, Fukunaga T, Sugimoto M, Ikesugi K, Sumi K, Hidaka H and Uji Y: The effect of the H-1152P, a potent Rho-associated coiled coil-formed protein kinase inhibitor, in rabbit normal and ocular hypertensive eyes. Curr Eye Res. 34:282–286. 2009. View Article : Google Scholar : PubMed/NCBI

120. 

Whitlock NA, Harrison B, Mixon T, Yu XQ, Wilson A, Gerhardt B, Eberhart DE, Abuin A and Rice DS: Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK. J Ocul Pharmacol Ther. 25:187–194. 2009. View Article : Google Scholar : PubMed/NCBI

121. 

Lama PJ and Fechtner RD: Antifibrotics and wound healing in glaucoma surgery. Surv Ophthalmol. 48:314–346. 2003. View Article : Google Scholar : PubMed/NCBI

122. 

Yoon PS and Singh K: Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery. Curr Opin Ophthalmol. 15:141–146. 2004. View Article : Google Scholar : PubMed/NCBI

123. 

Migdal C, Gregory W and Hitchings R: Long-term functional outcome after early surgery compared with laser and medicine in open-angle glaucoma. Ophthalmology. 101:1651–1656. 1994. View Article : Google Scholar : PubMed/NCBI

124. 

Khaw PT, Occleston NL, Schultz G, Grierson I, Sherwood MB and Larkin G: Activation and suppression of fibroblast function. Eye. 8:188–195. 1994. View Article : Google Scholar

125. 

Occleston NL, Daniels JT, Tarnuzzer RW, Sethi KK, Alexander RA, Bhattacharya SS, Schultz GS and Khaw PT: Single exposures to antiproliferatives: long-term effects on ocular fibroblast wound-healing behavior. Invest Ophthalmol Vis Sci. 38:1998–2007. 1997.PubMed/NCBI

126. 

Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C and Brown RA: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 3:349–363. 2002. View Article : Google Scholar : PubMed/NCBI

127. 

Hinz B, Mastrangelo D, Iselin CE, Chaponnier C and Gabbiani G: Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am J Pathol. 159:1009–1020. 2001. View Article : Google Scholar : PubMed/NCBI

128. 

Desmouliere A, Chaponnier C and Gabbiani G: Tissue repair, contraction, and the myofibroblast. Wound Repair Regen. 13:7–12. 2005. View Article : Google Scholar : PubMed/NCBI

129. 

Meyer-Ter-Vehn T, Gebhardt S, Sebald W, Buttmann M, Grehn F, Schlunck G and Knaus P: p38 inhibitors prevent TGF-β-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci. 47:1500–1509. 2006.

130. 

Ehrlich HP and Rajaratnam JB: Cell locomotion forces versus cell contraction forces for collagen lattice contraction: an in vitro model of wound contraction. Tissue Cell. 22:407–417. 1990. View Article : Google Scholar : PubMed/NCBI

131. 

Desmouliere A, Redard M, Darby I and Gabbiani G: Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol. 146:56–66. 1995.PubMed/NCBI

132. 

Darby IA and Hewitson TD: Fibroblast differentiation in wound healing and fibrosis. Int Rev Cytol. 257:143–179. 2007. View Article : Google Scholar : PubMed/NCBI

133. 

Meyer-ter-Vehn T, Sieprath S, Katzenberger B, Gebhardt S, Grehn F and Schlunck G: Contractility as a prerequisite for TGF-β-induced myofibroblast transdifferentiation in human tenon fibroblasts. Invest Ophthalmol Vis Sci. 47:4895–4904. 2006.

134. 

Miller MH, Grierson I, Unger WI and Hitchings RA: Wound healing in an animal model of glaucoma fistulizing surgery in the rabbit. Ophthalmic Surg. 20:350–357. 1989.PubMed/NCBI

135. 

Desmouliere A, Geinoz A, Gabbiani F and Gabbiani G: Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 122:103–111. 1993. View Article : Google Scholar

136. 

Watsky MA: Lysophosphatidic acid, serum, and hyposmolarity activate Cl− currents in corneal keratocytes. Am J Physiol. 269:C1385–C1393. 1995.PubMed/NCBI

137. 

Cordeiro MF, Reichel MB, Gay JA, D’Esposita F, Alexander RA and Khaw PT: Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. Invest Ophthalmol Vis Sci. 40:1975–1982. 1999.PubMed/NCBI

138. 

Cordeiro MF, Chang L, Lim KS, Daniels JT, Pleass RD, Siriwardena D and Khaw PT: Modulating conjunctival wound healing. Eye. 14:536–547. 2000. View Article : Google Scholar

139. 

Wong TT, Mead AL and Khaw PT: Matrix metalloproteinase inhibition modulates postoperative scarring after experimental glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 44:1097–1103. 2003. View Article : Google Scholar

140. 

Itoh K, Yoshioka K, Akedo H, Uehata M, Ishizaki T and Narumiya S: An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nat Med. 5:221–225. 1999. View Article : Google Scholar : PubMed/NCBI

141. 

Harvey SA, Anderson SC and SundarRaj N: Downstream effects of ROCK signaling in cultured human corneal stromal cells: microarray analysis of gene expression. Invest Ophthalmol Vis Sci. 45:2168–2176. 2004. View Article : Google Scholar : PubMed/NCBI

142. 

Yoshizaki H, Ohba Y, Parrini MC, Dulyaninova NG, Bresnick AR, Mochizuki N and Matsuda M: Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem. 279:44756–44762. 2004. View Article : Google Scholar : PubMed/NCBI

143. 

Tomasek JJ, Vaughan MB, Kropp BP, Gabbiani G, Martin MD, Haaksma CJ and Hinz B: Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity. Wound Repair Regen. 14:313–320. 2006. View Article : Google Scholar : PubMed/NCBI

144. 

Parizi M, Howard EW and Tomasek JJ: Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase. Exp Cell Res. 254:210–220. 2000. View Article : Google Scholar : PubMed/NCBI

145. 

Tangkijvanich P, Melton AC, Santiskulvong C and Yee HF Jr: Rho and p38 MAP kinase signaling pathways mediate LPA-stimulated hepatic myofibroblast migration. J Biomed Sci. 10:352–358. 2003. View Article : Google Scholar : PubMed/NCBI

146. 

Honjo M, Tanihara H, Kameda T, Kawaji T, Yoshimura N and Araie M: Potential role of Rho-associated protein kinase inhibitor Y-27632 in glaucoma filtration surgery. Invest Ophthalmol Vis Sci. 48:5549–5557. 2007. View Article : Google Scholar : PubMed/NCBI

147. 

Lukas TJ, Miao H, Chen L, Riordan SM, Li W, Crabb AM, Wise A, Du P, Lin SM and Hernandez MR: Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors. Genome Biol. 9:R1112008. View Article : Google Scholar : PubMed/NCBI

148. 

Hathaway DR, March KL, Lash JA, Adam LP and Wilensky RL: Vascular smooth muscle. A review of the molecular basis of contractility. Circulation. 83:382–390. 1991. View Article : Google Scholar : PubMed/NCBI

149. 

Savineau JP and Marthan R: Modulation of the calcium sensitivity of the smooth muscle contractile apparatus: molecular mechanisms, pharmacological and pathophysiological implications. Fundam Clin Pharmacol. 11:289–299. 1997. View Article : Google Scholar

150. 

Mita M, Yanagihara H, Hishinuma S, Saito M and Walsh MP: Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J. 364:431–440. 2002. View Article : Google Scholar : PubMed/NCBI

151. 

Sward K, Mita M, Wilson DP, Deng JT, Susnjar M and Walsh MP: The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction. Curr Hypertens Rep. 5:66–72. 2003. View Article : Google Scholar : PubMed/NCBI

152. 

Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K and Takeshita A: Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation. 101:1319–1323. 2000. View Article : Google Scholar : PubMed/NCBI

153. 

Sato M, Tani E, Fujikawa H and Kaibuchi K: Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res. 87:195–200. 2000. View Article : Google Scholar : PubMed/NCBI

154. 

Iizuka K, Shimizu Y, Tsukagoshi H, Yoshii A, Harada T, Dobashi K, Murozono T, Nakazawa T and Mori M: Evaluation of Y-27632, a rho-kinase inhibitor, as a bronchodilator in guinea pigs. Eur J Pharmacol. 406:273–279. 2000. View Article : Google Scholar : PubMed/NCBI

155. 

Chitaley K, Wingard CJ, Clinton Webb R, Branam H, Stopper VS, Lewis RW and Mills TM: Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med. 7:119–122. 2001. View Article : Google Scholar : PubMed/NCBI

156. 

Takahashi R, Nishimura J, Hirano K, Seki N, Naito S and Kanaide H: Ca2+ sensitization in contraction of human bladder smooth muscle. J Urol. 172:748–752. 2004.

157. 

Schubert R, Kalentchuk VU and Krien U: Rho kinase inhibition partly weakens myogenic reactivity in rat small arteries by changing calcium sensitivity. Am J Physiol Heart Circ Physiol. 283:H2288–H2295. 2002. View Article : Google Scholar : PubMed/NCBI

158. 

Cavarape A, Bauer J, Bartoli E, Endlich K and Parekh N: Effects of angiotensin II, arginine vasopressin and tromboxane A2 in renal vascular bed: role of rho-kinase. Nephrol Dial Transplant. 18:1764–1769. 2003. View Article : Google Scholar : PubMed/NCBI

159. 

Cavarape A, Endlich N, Assaloni R, Bartoli E, Steinhausen M, Parekh N and Endlich K: Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo. J Am Soc Nephrol. 14:37–45. 2003. View Article : Google Scholar : PubMed/NCBI

160. 

Randriamboavonjy V, Busse R and Fleming I: 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension. 41:801–806. 2003. View Article : Google Scholar : PubMed/NCBI

161. 

Watabe H, Abe S and Yoshitomi T: Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries. Jpn J Ophthalmol. 55:411–417. 2011. View Article : Google Scholar : PubMed/NCBI

162. 

Tokushige H: ROCK inhibitor and glaucoma. Bio Clinica. 17:1191–1194. 2002.

163. 

Sugiyama T, Shibata M, Kajiura S, Okuno T, Tonari M, Oku H and Ikeda T: Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits. Invest Ophthalmol Vis Sci. 52:64–69. 2011. View Article : Google Scholar : PubMed/NCBI

164. 

Okamura N, Saito M, Mori A, Sakamoto K, Kametaka S, Nakahara T and Ishii K: Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats. J Ocul Pharmacol Ther. 23:207–212. 2007. View Article : Google Scholar : PubMed/NCBI

165. 

Wolfrum S, Dendorfer A, Rikitake Y, Stalker TJ, Gong Y, Scalia R, Dominiak P and Liao JK: Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol. 24:1842–1847. 2004. View Article : Google Scholar : PubMed/NCBI

166. 

Anderson DR: Introductory comments on blood flow auto-regulation in the optic nerve head and vascular risk factors in glaucoma. Surv Ophthalmol. 43:S5–S9. 1999. View Article : Google Scholar : PubMed/NCBI

167. 

Chung HS, Harris A, Evans DW, Kagemann L, Garzozi HJ and Martin B: Vascular aspects in the pathophysiology of glaucomatous optic neuropathy. Surv Ophthalmol. 43:S43–S50. 1999. View Article : Google Scholar : PubMed/NCBI

168. 

Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP and Stefansson E: The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 21:359–393. 2002. View Article : Google Scholar : PubMed/NCBI

169. 

Ben Simon GJ, Moroz I, Goldenfeld M and Melamed S: Scanning laser Doppler flowmetry of nonperfused regions of the optic nerve head in patients with glaucoma. Ophthalmic Surg Lasers Imaging. 34:245–250. 2003.PubMed/NCBI

170. 

Hu Y, Cui Q and Harvey AR: Interactive effects of C3, cyclic AMP and ciliaryneurotrophic factor on adult retinal ganglion cell survival and axonal regeneration. Mol Cell Neurosci. 34:88–98. 2007. View Article : Google Scholar : PubMed/NCBI

171. 

Kitaoka Y, Kitaoka Y, Kumai T, Lam TT, Kuribayashi K, Isenoumi K, Munemasa Y, Motoki M, Kobayashi S and Ueno S: Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina. Brain Res. 1018:111–118. 2004. View Article : Google Scholar : PubMed/NCBI

172. 

Bertrand J, Di Polo A and McKerracher L: Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists. Neurobiol Dis. 25:65–72. 2007. View Article : Google Scholar : PubMed/NCBI

173. 

Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU and Masuda J: Lysophosphatidylcholine induces glial cell activation: role of rho kinase. Glia. 57:898–907. 2009. View Article : Google Scholar : PubMed/NCBI

174. 

Buchi ER: Cell death in the rat retina after a pressure-induced ischaemia-reperfusion insult: an electron microscopic study. I Ganglion cell layer and inner nuclear layer. Exp Eye Res. 55:605–613. 1992. View Article : Google Scholar

175. 

Rosenbaum DM, Rosenbaum PS, Gupta A, Michaelson MD, Hall DH and Kessler JA: Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Vision Res. 37:3445–3451. 1997. View Article : Google Scholar : PubMed/NCBI

176. 

Hirooka K, Miyamoto O, Jinming P, Du Y, Itano T, Baba T, Tokuda M and Shiraga F: Neuroprotective effects of D-allose against retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 47:1653–1657. 2006. View Article : Google Scholar : PubMed/NCBI

177. 

Millán J and Ridley AJ: Free in PMC Rho GTPases and leucocyte-induced endothelial remodelling. Biochem J. 385:329–337. 2005.PubMed/NCBI

178. 

Wittchen ES, van Buul JD, Burridge K and Worthylake RA: Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration. Curr Opin Hematol. 12:14–21. 2005. View Article : Google Scholar : PubMed/NCBI

179. 

Song H and Gao D: Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. Int J Mol Med. 28:193–198. 2011.PubMed/NCBI

180. 

Tsujikawa A, Ogura Y, Hiroshiba N, Miyamoto K, Kiryu J, Tojo SJ, Miyasaka M and Honda Y: Retinal ischemia-reperfusion injury attenuated by blocking of adhesion molecules of vascular endothelium. Invest Ophthalmol Vis Sci. 40:1183–1190. 1999.PubMed/NCBI

181. 

Hirata A, Inatani M, Inomata Y, Yonemura N, Kawaji T, Honjo M and Tanihara H: Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia. Graefes Arch Clin Exp Ophthalmol. 246:51–59. 2008. View Article : Google Scholar : PubMed/NCBI

182. 

Lingor P, Tönges L, Pieper N, Bermel C, Barski E, Planchamp V and Bähr M: ROCK inhibition and CNTF interact on intrinsic signalling pathways and differentially regulate survival and regeneration in retinal ganglion cells. Brain. 131:250–263. 2008.PubMed/NCBI

183. 

Tura A, Schuettauf F, Monnier PP, Bartz-Schmidt KU and Henke-Fahle S: Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina. Invest Ophthalmol Vis Sci. 50:452–461. 2009. View Article : Google Scholar : PubMed/NCBI

184. 

Fournier AE, GrandPre T, Gould G, Wang X and Strittmatter SM: Nogo and the Nogo-66 receptor. Prog Brain Res. 137:361–369. 2002. View Article : Google Scholar

185. 

Hunt D, Coffin RS and Anderson PN: The Nogo receptor, its ligands and axonal regeneration in the spinal cord; a review. J Neurocytol. 31:93–120. 2002. View Article : Google Scholar

186. 

McKerracher L and Winton MJ: Nogo on the go. Neuron. 36:345–348. 2002. View Article : Google Scholar : PubMed/NCBI

187. 

Sandvig A, Berry M, Barrett LB, Butt A and Logan A: Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia. 46:225–251. 2004. View Article : Google Scholar : PubMed/NCBI

188. 

Fawcett JW: Overcoming inhibition in the damaged spinal cord. J Neurotrauma. 23:371–383. 2006. View Article : Google Scholar : PubMed/NCBI

189. 

Du J, Fu C and Sretavan DW: Eph/ephrin signaling as a potential therapeutic target after central nervous system injury. Curr Pharm Des. 13:2507–2518. 2007. View Article : Google Scholar : PubMed/NCBI

190. 

Fabes J, Anderson P, Brennan C and Bolsove S: Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cord. Eur J Neurosci. 26:2496–2505. 2007. View Article : Google Scholar : PubMed/NCBI

191. 

Hou ST, Jiang SX and Smith RA: Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration. Int Rev Cell Molec Biol. 267:125–181. 2008. View Article : Google Scholar : PubMed/NCBI

192. 

Berry M, Ahmed Z, Lorber B, Douglas M and Logan A: Regeneration of axons in the visual system. Restor Neurol Neurosci. 26:147–174. 2008.PubMed/NCBI

193. 

Bertrand J, Winton MJ, Rodriguez-Hernandez N, Campenot RB and McKerracher L: Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci. 25:1113–1121. 2005. View Article : Google Scholar : PubMed/NCBI

194. 

Sagawa H, Terasaki H, Nakamura M, Ichikawa M, Yata T, Tokita Y and Watanabe M: A novel ROCK inhibitor, Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Exp Neurol. 205:230–240. 2007. View Article : Google Scholar : PubMed/NCBI

195. 

Monnier PP, Sierra A, Schwab JM, Henke-Fahle S and Mueller BK: The Rho/ROCK pathway mediates neurite growth-inhibitory activity associated with the chondroitin sulfate proteoglycans of the CNS glial scar. Mol Cell Neurosci. 22:319–330. 2003. View Article : Google Scholar : PubMed/NCBI

196. 

Lingor P, Teusch N, Schwarz K, Mueller R, Mack H, Bahr M and Mueller BK: Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. J Neurochem. 103:181–189. 2007.PubMed/NCBI

197. 

Ahmed Z, Berry M and Logan A: ROCK inhibition promotes adult retinal ganglion cell neurite outgrowth only in the presence of growth promoting factors. Mol Cell Neurosci. 42:128–133. 2009. View Article : Google Scholar : PubMed/NCBI

198. 

Watanabe M: Regeneration of optic nerve fibers of adult mammals. Dev Growth Differ. 52:567–576. 2010. View Article : Google Scholar : PubMed/NCBI

199. 

Tan H, Zhong Y, Shen X, Cheng Y, Jiao Q and Deng L: Erythropoietin promotes axonal regeneration after optic nerve crush in vivo by inhibition of RhoA/ROCK signaling pathway. Neuropharmacology. 63:1182–1190. 2012. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Wang J, Liu X and Zhong Y: Rho/Rho-associated kinase pathway in glaucoma (Review) . Int J Oncol 43: 1357-1367, 2013.
APA
Wang, J., Liu, X., & Zhong, Y. (2013). Rho/Rho-associated kinase pathway in glaucoma (Review) . International Journal of Oncology, 43, 1357-1367. https://doi.org/10.3892/ijo.2013.2100
MLA
Wang, J., Liu, X., Zhong, Y."Rho/Rho-associated kinase pathway in glaucoma (Review) ". International Journal of Oncology 43.5 (2013): 1357-1367.
Chicago
Wang, J., Liu, X., Zhong, Y."Rho/Rho-associated kinase pathway in glaucoma (Review) ". International Journal of Oncology 43, no. 5 (2013): 1357-1367. https://doi.org/10.3892/ijo.2013.2100
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Liu X and Zhong Y: Rho/Rho-associated kinase pathway in glaucoma (Review) . Int J Oncol 43: 1357-1367, 2013.
APA
Wang, J., Liu, X., & Zhong, Y. (2013). Rho/Rho-associated kinase pathway in glaucoma (Review) . International Journal of Oncology, 43, 1357-1367. https://doi.org/10.3892/ijo.2013.2100
MLA
Wang, J., Liu, X., Zhong, Y."Rho/Rho-associated kinase pathway in glaucoma (Review) ". International Journal of Oncology 43.5 (2013): 1357-1367.
Chicago
Wang, J., Liu, X., Zhong, Y."Rho/Rho-associated kinase pathway in glaucoma (Review) ". International Journal of Oncology 43, no. 5 (2013): 1357-1367. https://doi.org/10.3892/ijo.2013.2100
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