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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2013 Volume 43 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2013 Volume 43 Issue 6

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Article

Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway

  • Authors:
    • Marvin Xuejun Xu
    • Linlin Zhao
    • Chaoyang Deng
    • Lu Yang
    • Yang Wang
    • Tao Guo
    • Lifang Li
    • Jianping Lin
    • Lirong Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Basic Medical College, Zhengzhou University, Zhengzhou 450001, P.R. China, Shanghai McAry Biomedical Technology Co. Ltd., Shanghai 201203, P.R. China, Huaihe Hospital, Henan University, Kaifeng 475000, P.R. China, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 2012203, P.R. China, College of Pharmacy, Nankai University, Tianjin 300071, P.R. China
  • Pages: 1951-1959
    |
    Published online on: September 23, 2013
       https://doi.org/10.3892/ijo.2013.2107
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Abstract

Curcumin from the rhizome of Curcuma longa (zingiberaceae) has been reported to be a chemopreventive agent that affects cell proliferation by arresting the cell cycle in G2 and modulating the wnt signaling pathway. We found that curcumin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma (HCC) cells in a concentration-dependent manner. We identified that curcumin interrupts wnt signaling by decreasing β-catenin activity, which in turn suppresses the expression of β-catenin target genes (c-myc, VEGF and cyclin D1). Our results from molecular simulation of curcumin binding to Dvl2 protein and from binding free energy calculations suggest that curcumin may prevent axin recruitment to cellular membrane in order to maintain the functional β-catenin destruction complex in normal cells. This results in β-catenin being unable to accumulate in the nucleus, depriving the protein of its ability to bind with lymphoid enhancer factor/T cell-specific transcription factor (Lef/Tcf) and repressing its activation of target gene transcription. This may be one mechanism through which curcumin inhibits proliferation and induces apoptosis of HCC cells.

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Copy and paste a formatted citation
Spandidos Publications style
Xu MX, Zhao L, Deng C, Yang L, Wang Y, Guo T, Li L, Lin J and Zhang L: Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. Int J Oncol 43: 1951-1959, 2013.
APA
Xu, M.X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T. ... Zhang, L. (2013). Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. International Journal of Oncology, 43, 1951-1959. https://doi.org/10.3892/ijo.2013.2107
MLA
Xu, M. X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T., Li, L., Lin, J., Zhang, L."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway". International Journal of Oncology 43.6 (2013): 1951-1959.
Chicago
Xu, M. X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T., Li, L., Lin, J., Zhang, L."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway". International Journal of Oncology 43, no. 6 (2013): 1951-1959. https://doi.org/10.3892/ijo.2013.2107
Copy and paste a formatted citation
x
Spandidos Publications style
Xu MX, Zhao L, Deng C, Yang L, Wang Y, Guo T, Li L, Lin J and Zhang L: Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. Int J Oncol 43: 1951-1959, 2013.
APA
Xu, M.X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T. ... Zhang, L. (2013). Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. International Journal of Oncology, 43, 1951-1959. https://doi.org/10.3892/ijo.2013.2107
MLA
Xu, M. X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T., Li, L., Lin, J., Zhang, L."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway". International Journal of Oncology 43.6 (2013): 1951-1959.
Chicago
Xu, M. X., Zhao, L., Deng, C., Yang, L., Wang, Y., Guo, T., Li, L., Lin, J., Zhang, L."Curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway". International Journal of Oncology 43, no. 6 (2013): 1951-1959. https://doi.org/10.3892/ijo.2013.2107
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