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International Journal of Oncology
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Article

SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer

  • Authors:
    • Jia Gu
    • Tao Han
    • Rui-Hang Ma
    • Yu-Lin Zhu
    • Yi-Na Jia
    • Jing-Jing Du
    • Yu Chen
    • Xue-Jun Jiang
    • Xiao-Dong Xie
    • Xing Guo
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang 110001, P.R. China, Department of Oncology, General Hospital of Shenyang Military Region, Shenyang 110016, P.R. China, Department of Operation Room, General Hospital of Shenyang Military Region, Shenyang 110016, P.R. China
  • Pages: 481-490
    |
    Published online on: November 28, 2013
       https://doi.org/10.3892/ijo.2013.2191
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Abstract

The overall survival rate and prognosis of patients with laryngeal cancer are not optimistic despite advances in therapeutic techniques. Gene expression prognostic models enable the development of more appropriate treatment strategies. The human gene PTPN11 encoding a non-receptor protein tyrosine phosphatase, Src homology phosphotyrosine phosphatase 2 (SHP2), is a well-documented proto-oncogene in various malignancies. This study investigated the role of SHP2 expression and associated clinical manifestations in laryngeal cancer using a tissue microarray of 112 pairs of laryngeal cancer samples and corresponding adjacent normal mucosae. SHP2 expression increased in laryngeal cancer, and this result was associated with the poor survival rate of laryngeal cancer patients. Moreover, increased SHP2 expression remarkably promoted the growth of laryngeal cancer cells in vitro and tumorigenicity of laryngeal cancer cells in vivo. The Ras/Raf/Mek/Erk pathway was also found to be involved in the SHP2-induced growth of laryngeal cancer cells. Overall, our findings indicated that SHP2 plays an important role in laryngeal cancer tumorigenesis and that its expression is negatively correlated with the prognosis of patients. Thus, SHP2 may be a promising combinational therapeutic target for treatment of laryngeal cancer. The interference of SHP2 expression can serve as a novel strategy for laryngeal cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Gu J, Han T, Ma R, Zhu Y, Jia Y, Du J, Chen Y, Jiang X, Xie X, Guo X, Guo X, et al: SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer. Int J Oncol 44: 481-490, 2014.
APA
Gu, J., Han, T., Ma, R., Zhu, Y., Jia, Y., Du, J. ... Guo, X. (2014). SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer. International Journal of Oncology, 44, 481-490. https://doi.org/10.3892/ijo.2013.2191
MLA
Gu, J., Han, T., Ma, R., Zhu, Y., Jia, Y., Du, J., Chen, Y., Jiang, X., Xie, X., Guo, X."SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer". International Journal of Oncology 44.2 (2014): 481-490.
Chicago
Gu, J., Han, T., Ma, R., Zhu, Y., Jia, Y., Du, J., Chen, Y., Jiang, X., Xie, X., Guo, X."SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer". International Journal of Oncology 44, no. 2 (2014): 481-490. https://doi.org/10.3892/ijo.2013.2191
Copy and paste a formatted citation
x
Spandidos Publications style
Gu J, Han T, Ma R, Zhu Y, Jia Y, Du J, Chen Y, Jiang X, Xie X, Guo X, Guo X, et al: SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer. Int J Oncol 44: 481-490, 2014.
APA
Gu, J., Han, T., Ma, R., Zhu, Y., Jia, Y., Du, J. ... Guo, X. (2014). SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer. International Journal of Oncology, 44, 481-490. https://doi.org/10.3892/ijo.2013.2191
MLA
Gu, J., Han, T., Ma, R., Zhu, Y., Jia, Y., Du, J., Chen, Y., Jiang, X., Xie, X., Guo, X."SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer". International Journal of Oncology 44.2 (2014): 481-490.
Chicago
Gu, J., Han, T., Ma, R., Zhu, Y., Jia, Y., Du, J., Chen, Y., Jiang, X., Xie, X., Guo, X."SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer". International Journal of Oncology 44, no. 2 (2014): 481-490. https://doi.org/10.3892/ijo.2013.2191
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