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International Journal of Oncology
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Article

Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo

  • Authors:
    • Yanxia Zhao
    • Dandan Yu
    • Hongge Wu
    • Hongli Liu
    • Hongxia Zhou
    • Runxia Gu
    • Ruiguang Zhang
    • Sheng Zhang
    • Gang Wu
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China
  • Pages: 451-458
    |
    Published online on: November 28, 2013
       https://doi.org/10.3892/ijo.2013.2193
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Abstract

Suberoylanilide hydroxamic acid (SAHA), a potent pan-histone deacetylase (HDAC) inhibitor, has been clinically approved for the treatment of cutaneous T-cell lymphoma (CTCL). SAHA has also been shown to exert a variety of anticancer activities in many other types of tumors, however, few studies have been reported in large-cell lung carcinoma (LCC). Our study aimed to investigate the potential antitumor effects of SAHA on LCC cells. Here, we report that SAHA was able to inhibit the proliferation of the LCC cell line NCI-H460 in a dose- and time-dependent manner, induced cell apoptosis and G2/M cell cycle arrest, decreased AKT and ERK phosphorylation, inhibited the expression of pro-angiogenic factors (VEGF, HIF-1α) in vitro, and suppressed tumor progression in an NCI-H460 cell nude mouse xenograft model in vivo. These results indicate that SAHA can exert its strong antitumor effects in LCC patient.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Yu D, Wu H, Liu H, Zhou H, Gu R, Zhang R, Zhang S and Wu G: Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo. Int J Oncol 44: 451-458, 2014.
APA
Zhao, Y., Yu, D., Wu, H., Liu, H., Zhou, H., Gu, R. ... Wu, G. (2014). Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo. International Journal of Oncology, 44, 451-458. https://doi.org/10.3892/ijo.2013.2193
MLA
Zhao, Y., Yu, D., Wu, H., Liu, H., Zhou, H., Gu, R., Zhang, R., Zhang, S., Wu, G."Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo". International Journal of Oncology 44.2 (2014): 451-458.
Chicago
Zhao, Y., Yu, D., Wu, H., Liu, H., Zhou, H., Gu, R., Zhang, R., Zhang, S., Wu, G."Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo". International Journal of Oncology 44, no. 2 (2014): 451-458. https://doi.org/10.3892/ijo.2013.2193
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Yu D, Wu H, Liu H, Zhou H, Gu R, Zhang R, Zhang S and Wu G: Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo. Int J Oncol 44: 451-458, 2014.
APA
Zhao, Y., Yu, D., Wu, H., Liu, H., Zhou, H., Gu, R. ... Wu, G. (2014). Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo. International Journal of Oncology, 44, 451-458. https://doi.org/10.3892/ijo.2013.2193
MLA
Zhao, Y., Yu, D., Wu, H., Liu, H., Zhou, H., Gu, R., Zhang, R., Zhang, S., Wu, G."Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo". International Journal of Oncology 44.2 (2014): 451-458.
Chicago
Zhao, Y., Yu, D., Wu, H., Liu, H., Zhou, H., Gu, R., Zhang, R., Zhang, S., Wu, G."Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo". International Journal of Oncology 44, no. 2 (2014): 451-458. https://doi.org/10.3892/ijo.2013.2193
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