|
1.
|
Herman JG and Baylin SB: Gene silencing in
cancer in association with promoter hypermethylation. N Engl J Med.
349:2042–2054. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
2.
|
Baylin S: DNA methylation and epigenetic
mechanisms of carcinogenesis. Dev Biol (Basel). 106:85–87.
2001.PubMed/NCBI
|
|
3.
|
Baylin SB, Herman JG, Graff JR, Vertino PM
and Issa JP: Alterations in DNA methylation: a fundamental aspect
of neoplasia. Adv Cancer Res. 72:141–196. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
4.
|
Feinberg AP and Vogelstein B:
Hypomethylation of ras oncogenes in primary human cancers. Biochem
Biophys Res Commun. 111:47–54. 1983. View Article : Google Scholar : PubMed/NCBI
|
|
5.
|
Narayan A, Ji W, Zhang XY, Marrogi A,
Graff JR, Baylin SB and Ehrlich M: Hypomethylation of
pericentromeric DNA in breast adenocarcinomas. Int J Cancer.
77:833–838. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
6.
|
Eden A, Gaudet F, Waghmare A and Jaenisch
R: Chromosomal instability and tumors promoted by DNA
hypomethylation. Science. 300:4552003. View Article : Google Scholar : PubMed/NCBI
|
|
7.
|
Gaudet F, Hodgson JG, Eden A,
Jackson-Grusby L, Dausman J, Gray JW, Leonhardt H and Jaenisch R:
Induction of tumors in mice by genomic hypomethylation. Science.
300:489–492. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Jones PA and Laird PW: Cancer epigenetics
comes of age. Nat Genet. 21:163–167. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
9.
|
Kanai Y and Hirohashi S: Alterations of
DNA methylation associated with abnormalities of DNA
methyltransferases in human cancers during transition from a
precancerous to a malignant state. Carcinogenesis. 28:2434–2442.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
10.
|
Lewis CM, Cler LR, Bu DW, Zochbauer-Muller
S, Milchgrub S, Naftalis EZ, Leitch AM, Minna JD and Euhus DM:
Promoter hypermethylation in benign breast epithelium in relation
to predicted breast cancer risk. Clin Cancer Res. 11:166–172.
2005.PubMed/NCBI
|
|
11.
|
Ai L, Kim WJ, Kim TY, Fields CR, Massoll
NA, Robertson KD and Brown KD: Epigenetic silencing of the tumor
suppressor cystatin M occurs during breast cancer progression.
Cancer Res. 66:7899–7909. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
12.
|
Roll JD, Rivenbark AG, Jones WD and
Coleman WB: DNMT3b overexpression contributes to a hypermethylator
phenotype in human breast cancer cell lines. Mol Cancer. 7:152008.
View Article : Google Scholar : PubMed/NCBI
|
|
13.
|
Girault I, Tozlu S, Lidereau R and Bieche
I: Expression analysis of DNA methyltransferases 1, 3A, and 3B in
sporadic breast carcinomas. Clin Cancer Res. 9:4415–4422.
2003.PubMed/NCBI
|
|
14.
|
Robertson KD, Uzvolgyi E, Liang G,
Talmadge C, Sumegi J, Gonzales FA and Jones PA: The human DNA
methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression
in normal tissues and overexpression in tumors. Nucleic Acids Res.
27:2291–2298. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
15.
|
Mizuno S, Chijiwa T, Okamura T, Akashi K,
Fukumaki Y, Niho Y and Sasaki H: Expression of DNA
methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in
acute and chronic myelogenous leukemia. Blood. 97:1172–1179. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
16.
|
Jin F, Dowdy SC, Xiong Y, Eberhardt NL,
Podratz KC and Jiang SW: Up-regulation of DNA methyltransferase 3B
expression in endometrial cancers. Gynecol Oncol. 96:531–538. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
17.
|
Veeck J and Esteller M: Breast cancer
epigenetics: from DNA methylation to microRNAs. J Mammary Gland
Biol Neoplasia. 15:5–17. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
18.
|
Melo SA and Esteller M: Dysregulation of
microRNAs in cancer: Playing with fire. FEBS Lett. 585:2087–2099.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
19.
|
Giraldez AJ, Mishima Y, Rihel J, Grocock
RJ, Van Dongen S, Inoue K, Enright AJ and Schier AF: Zebrafish
MiR-430 promotes deadenylation and clearance of maternal mRNAs.
Science. 312:75–79. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20.
|
Bartel B: MicroRNAs directing siRNA
biogenesis. Nat Struct Mol Biol. 12:569–571. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
21.
|
Bartel DP: MicroRNAs: genomics,
biogenesis, mechanism, and function. Cell. 116:281–297. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
22.
|
Bagga S, Bracht J, Hunter S, Massirer K,
Holtz J, Eachus R and Pasquinelli AE: Regulation by let-7 and lin-4
miRNAs results in target mRNA degradation. Cell. 122:553–563. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
23.
|
Pillai RS, Bhattacharyya SN, Artus CG,
Zoller T, Cougot N, Basyuk E, Bertrand E and Filipowicz W:
Inhibition of translational initiation by Let-7 MicroRNA in human
cells. Science. 309:1573–1576. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
24.
|
Sevignani C, Calin GA, Siracusa LD and
Croce CM: Mammalian microRNAs: a small world for fine-tuning gene
expression. Mamm Genome. 17:189–202. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
25.
|
Miska EA: How microRNAs control cell
division, differentiation and death. Curr Opin Genet Dev.
15:563–568. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
26.
|
Carleton M, Cleary MA and Linsley PS:
MicroRNAs and cell cycle regulation. Cell Cycle. 6:2127–2132. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
27.
|
Ambros V: The functions of animal
microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
28.
|
Calin GA, Dumitru CD, Shimizu M, Bichi R,
Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L,
Kipps T, Negrini M, Bullrich F and Croce CM: Frequent deletions and
down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in
chronic lymphocytic leukemia. Proc Natl Acad Sci USA.
99:15524–15529. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
29.
|
Iorio MV, Ferracin M, Liu CG, Veronese A,
Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M,
Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I,
Calin GA, Querzoli P, Negrini M and Croce CM: MicroRNA gene
expression deregulation in human breast cancer. Cancer Res.
65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
30.
|
Lujambio A, Calin GA, Villanueva A, Ropero
S, Sanchez-Cespedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso
MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM and Esteller M: A
microRNA DNA methylation signature for human cancer metastasis.
Proc Natl Acad Sci USA. 105:13556–13561. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
31.
|
Hayashita Y, Osada H, Tatematsu Y, Yamada
H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y and
Takahashi T: A polycistronic microRNA cluster, miR-17-92, is
overexpressed in human lung cancers and enhances cell
proliferation. Cancer Res. 65:9628–9632. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
32.
|
Korpal M, Lee ES, Hu G and Kang Y: The
miR-200 family inhibits epithelial-mesenchymal transition and
cancer cell migration by direct targeting of E-cadherin
transcriptional repressors ZEB1 and ZEB2. J Biol Chem.
283:14910–14914. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
33.
|
Anand S, Majeti BK, Acevedo LM, Murphy EA,
Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN,
Lapinski PE, King PD, Weis SM and Cheresh DA: MicroRNA-132-mediated
loss of p120RasGAP activates the endothelium to facilitate
pathological angiogenesis. Nat Med. 16:909–914. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
34.
|
Ma L, Teruya-Feldstein J and Weinberg RA:
Tumour invasion and metastasis initiated by microRNA-10b in breast
cancer. Nature. 449:682–688. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
35.
|
Fabbri M, Garzon R, Cimmino A, Liu Z,
Zanesi N, Callegari E, Liu S, Alder H, Costinean S,
Fernandez-Cymering C, Volinia S, Guler G, Morrison CD, Chan KK,
Marcucci G, Calin GA, Huebner K and Croce CM: MicroRNA-29 family
reverts aberrant methylation in lung cancer by targeting DNA
methyltransferases 3A and 3B. Proc Natl Acad Sci USA.
104:15805–15810. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36.
|
Garzon R, Liu S, Fabbri M, Liu Z, Heaphy
CE, Callegari E, Schwind S, Pang J, Yu J, Muthusamy N, Havelange V,
Volinia S, Blum W, Rush LJ, Perrotti D, Andreeff M, Bloomfield CD,
Byrd JC, Chan K, Wu LC, Croce CM and Marcucci G: MicroRNA-29b
induces global DNA hypomethylation and tumor suppressor gene
reexpression in acute myeloid leukemia by targeting directly DNMT3A
and 3B and indirectly DNMT1. Blood. 113:6411–6418. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
37.
|
Duursma AM, Kedde M, Schrier M, le Sage C
and Agami R: miR-148 targets human DNMT3b protein coding region.
RNA. 14:872–877. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
38.
|
Sandhu R, Rivenbark AG and Coleman WB:
Loss of post-transcriptional regulation of DNMT3b by microRNAs: a
possible molecular mechanism for the hypermethylation defect
observed in a subset of breast cancer cell lines. Int J Oncol.
41:721–732. 2012.PubMed/NCBI
|
|
39.
|
Livasy CA, Karaca G, Nanda R, Tretiakova
MS, Olopade OI, Moore DT and Perou CM: Phenotypic evaluation of the
basal-like subtype of invasive breast carcinoma. Mod Pathol.
19:264–271. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
40.
|
Nielsen TO, Hsu FD, Jensen K, Cheang M,
Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler
L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M and Perou
CM: Immunohistochemical and clinical characterization of the
basal-like subtype of invasive breast carcinoma. Clin Cancer Res.
10:5367–5374. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
41.
|
Harvey JM, Clark GM, Osborne CK and Allred
DC: Estrogen receptor status by immunohistochemistry is superior to
the ligand-binding assay for predicting response to adjuvant
endocrine therapy in breast cancer. J Clin Oncol. 17:1474–1481.
1999.PubMed/NCBI
|
|
42.
|
Perou CM, Sorlie T, Eisen MB, van de Rijn
M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA,
Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE,
Borresen-Dale AL, Brown PO and Botstein D: Molecular portraits of
human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
43.
|
Sorlie T, Perou CM, Tibshirani R, Aas T,
Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey
SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein
Lonning P and Borresen-Dale AL: Gene expression patterns of breast
carcinomas distinguish tumor subclasses with clinical implications.
Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
44.
|
Sorlie T, Tibshirani R, Parker J, Hastie
T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S,
Demeter J, Perou CM, Lonning PE, Brown PO, Borresen-Dale AL and
Botstein D: Repeated observation of breast tumor subtypes in
independent gene expression data sets. Proc Natl Acad Sci USA.
100:8418–8423. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
45.
|
Gaur A, Jewell DA, Liang Y, Ridzon D,
Moore JH, Chen C, Ambros VR and Israel MA: Characterization of
microRNA expression levels and their biological correlates in human
cancer cell lines. Cancer Res. 67:2456–2468. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
46.
|
Feinberg AP and Tycko B: The history of
cancer epigenetics. Nat Rev Cancer. 4:143–153. 2004. View Article : Google Scholar
|
|
47.
|
Esteller M: Epigenetics in cancer. N Engl
J Med. 358:1148–1159. 2008. View Article : Google Scholar
|
|
48.
|
Yang X, Yan L and Davidson NE: DNA
methylation in breast cancer. Endocr Relat Cancer. 8:115–127. 2001.
View Article : Google Scholar
|
|
49.
|
Esteller M: CpG island hypermethylation
and tumor suppressor genes: a booming present, a brighter future.
Oncogene. 21:5427–5440. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
50.
|
Toyota M, Ahuja N, Ohe-Toyota M, Herman
JG, Baylin SB and Issa JP: CpG island methylator phenotype in
colorectal cancer. Proc Natl Acad Sci USA. 96:8681–8686. 1999.
View Article : Google Scholar : PubMed/NCBI
|
|
51.
|
Shen L, Ahuja N, Shen Y, Habib NA, Toyota
M, Rashid A and Issa JP: DNA methylation and environmental
exposures in human hepatocellular carcinoma. J Natl Cancer Inst.
94:755–761. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
52.
|
Toyota M, Ahuja N, Suzuki H, Itoh F,
Ohe-Toyota M, Imai K, Baylin SB and Issa JP: Aberrant methylation
in gastric cancer associated with the CpG island methylator
phenotype. Cancer Res. 59:5438–5442. 1999.PubMed/NCBI
|
|
53.
|
Nikiforova MN, Tseng GC, Steward D, Diorio
D and Nikiforov YE: MicroRNA expression profiling of thyroid
tumors: biological significance and diagnostic utility. J Clin
Endocrinol Metab. 93:1600–1608. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
54.
|
Corcoran C, Friel AM, Duffy MJ, Crown J
and O’Driscoll L: Intracellular and extracellular microRNAs in
breast cancer. Clin Chem. 57:18–32. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
55.
|
Garzon R, Calin GA and Croce CM: MicroRNAs
in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar
|
|
56.
|
Calin GA, Ferracin M, Cimmino A, Di Leva
G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M,
Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C,
Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M and
Croce CM: A MicroRNA signature associated with prognosis and
progression in chronic lymphocytic leukemia. N Engl J Med.
353:1793–1801. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
57.
|
Yanaihara N, Caplen N, Bowman E, Seike M,
Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, Calin
GA, Liu CG, Croce CM and Harris CC: Unique microRNA molecular
profiles in lung cancer diagnosis and prognosis. Cancer Cell.
9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
58.
|
Garzon R, Volinia S, Liu CG,
Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K,
Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau
SM, Kantarjian H, Bloomfield CD, Andreeff M and Croce CM: MicroRNA
signatures associated with cytogenetics and prognosis in acute
myeloid leukemia. Blood. 111:3183–3189. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
59.
|
Mott JL, Kobayashi S, Bronk SF and Gores
GJ: mir-29 regulates Mcl-1 protein expression and apoptosis.
Oncogene. 26:6133–6140. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
60.
|
Visone R and Croce CM: MiRNAs and cancer.
Am J Pathol. 174:1131–1138. 2009. View Article : Google Scholar
|
|
61.
|
Wang Y and Lee CG: MicroRNA and cancer -
focus on apoptosis. J Cell Mol Med. 13:12–23. 2009. View Article : Google Scholar
|
|
62.
|
Sengupta S, den Boon JA, Chen IH, Newton
MA, Stanhope SA, Cheng YJ, Chen CJ, Hildesheim A, Sugden B and
Ahlquist P: MicroRNA 29c is down-regulated in nasopharyngeal
carcinomas, up-regulating mRNAs encoding extracellular matrix
proteins. Proc Natl Acad Sci USA. 105:5874–5878. 2008. View Article : Google Scholar : PubMed/NCBI
|
